Abstract：
:To investigate the long-term functional change in the 5-HT(2A) receptor after acute stress, we examined the effect of single footshock on head shake behavior induced by the 5-HT(2A) receptor agent (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) in rats. Head shakes were evoked in a dose-dependent manner by 0.1-10 mg/kg of DOI, and the maximal response was attenuated by a single footshock given 24 h before. This suggests that there is a decrease in the number of functionally effective 5-HT(2A) receptors. The single footshock-induced reduction in head shakes evoked by DOI was observed immediately and 24 h after footshock, and lasted until 1 and 2 weeks after footshock. Because there were no changes in the [3H]ketanserin binding of the frontal cortex 1 week after footshock, decreases in head shakes were not due to the down-regulation of 5-HT(2A) receptors evoked by footshock.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Izumi T,Suzuki K,Inoue T,Li XB,Maki Y,Muraki I,Kitaichi Y,Hashimoto S,Koyama Tdoi
10.1016/s0014-2999(02)02302-6keywords:
subject
Has Abstractpub_date
2002-10-04 00:00:00pages
199-204issue
2eissn
0014-2999issn
1879-0712pii
S0014299902023026journal_volume
452pub_type
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