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Role of RhoA-ROCK signaling in Parkinson's disease.

Abstract：

:Parkinson's disease (PD) is a complex and widespread neurodegenerative disease characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the development of therapies that can stop or reverse the disease progression, identification of dependable biomarkers, and better understanding of the pathophysiological mechanisms of PD. RhoA-ROCK signals appear to have an important role in PD symptoms, making it a possible approach for PD treatment strategies. Activation of RhoA-ROCK (Rho-associated coiled-coil containing protein kinase) appears to stimulate various PD risk factors including aggregation of alpha-synuclein (αSyn), dysregulation of autophagy, and activation of apoptosis. This manuscript reviews current updates about the biology and function of the RhoA-ROCK pathway and discusses the possible role of this signaling pathway in causing the pathogenesis of PD. We conclude that inhibition of the RhoA-ROCK signaling pathway may have high translational potential and could be a promising therapeutic target in PD.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Iyer M,Subramaniam MD,Venkatesan D,Cho SG,Ryding M,Meyer M,Vellingiri B

doi

10.1016/j.ejphar.2020.173815

subject

Has Abstract

pub_date

2020-12-17 00:00:00

pages

173815

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(20)30920-1

journal_volume

894

pub_type

杂志文章,评审

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