Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin.

Abstract:

:The effect of histamine H3 receptor-selective ligands on [35S]guanosine 5'-o-(gamma-thio)triphosphate ([35S]GTP gamma[S]) binding has been examined in rat cerebral cortical membranes. R alpha-Methylhistamine and N alpha-methylhistamine produced a concentration-dependent stimulation of [35S]GTP gamma[S] binding which was attenuated in the presence of the selective histamine H3 receptor antagonist thioperamide. In addition, treatment of brain membranes with pertussis toxin abolished the histamine H3 receptor agonist stimulated binding of [35S]GTP gamma[S]. These results provide the first evidence that histamine H3 receptors couple directly to a Gi/Go protein in mammalian brain.

journal_name

Eur J Pharmacol

authors

Clark EA,Hill SJ

doi

10.1016/0014-2999(95)00800-4

subject

Has Abstract

pub_date

1996-01-25 00:00:00

pages

223-5

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(95)00800-4

journal_volume

296

pub_type

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