Abstract:
:Although initial resuscitation from cardiac arrest (CA) has increased over the past years, long term survival rates remain dismal. Epinephrine is the vasopressor of choice in the treatment of CA. However, its efficacy has been questioned, as it has no apparent benefits for long-term survival or favorable neurologic outcome. Levosimendan is an inodilator with cardioprotective and neuroprotective effects. Several studies suggest that it is associated with increased rates of return of spontaneous circulation as well as improved post-resuscitation myocardial function and neurological outcome. The purpose of this article is to review the properties of Levosimendan during cardiopulmonary resuscitation (CPR) and also to summarize existing evidence regarding the use of Levosimendan in the treatment of CA.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Varvarousi G,Stefaniotou A,Varvaroussis D,Aroni F,Xanthos Tdoi
10.1016/j.ejphar.2014.06.024subject
Has Abstractpub_date
2014-10-05 00:00:00pages
596-602eissn
0014-2999issn
1879-0712pii
S0014-2999(14)00466-Xjournal_volume
740pub_type
杂志文章,评审abstract::The ability of calcium entry blockers to inhibit allergic histamine release from rabbit leukocytes was studied. Bepridil, verapamil, nifedipine, diltiazem and TMB-8 produced concentration-dependent inhibition of allergic histamine release from rabbit leukocytes. The calculated IC50s (microM) were as follows: verapamil...
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pub_type: 杂志文章
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(87)90642-x
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:European journal of pharmacology
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