Evidence for a prostacyclin-mediated chronotropic effect of angiotensin II in the isolated cat right atria.

Abstract:

:The positive chronotropic effect of angiotensin II was studied on the isolated spontaneously beating cat right atria. Angiotensin II and prostacyclin produced similar positive chronotropic and inotropic effects which were not affected by beta-adrenoceptor and histamine H2-receptor blockers. [Sar1,Ile8] angiotensin II, however, inhibited the positive chronotropic and inotropic responses to angiotensin II without altering that to prostacyclin, noradrenaline and histamine. Nicotine completely abolished the positive chronotropic action of angiontensin II without altering its positive inotropic effect. Nicotine failed to abolish the effects of prostacyclin, noradrenaline and histamine on the rate and contractility. These results were taken as evidence that the angiotensin II-induced increase in heart rate is probably mediated through the increase of prostacyclin biosynthesis in the isolated cat right atria.

journal_name

Eur J Pharmacol

authors

Türker RK

doi

10.1016/0014-2999(82)90260-6

subject

Has Abstract

pub_date

1982-09-24 00:00:00

pages

271-5

issue

3-4

eissn

0014-2999

issn

1879-0712

pii

0014-2999(82)90260-6

journal_volume

83

pub_type

杂志文章
  • Glucocorticoids impair type I IFN signalling and enhance rhinovirus replication.

    abstract::Inhaled corticosteroids (ICS) are recommended treatments for all degrees of asthma severity and in combination with bronchodilators are indicated for COPD patients with a history of frequent exacerbations. However, the long-term side effects of glucocorticoids (GCs) may include increased risk of respiratory infections...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2020.173839

    authors: Marcellini A,Swieboda D,Guedán A,Farrow SN,Casolari P,Contoli M,Johnston SL,Papi A,Solari R

    更新日期:2021-02-15 00:00:00

  • Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-kappaB in RAW 264.7 cells.

    abstract::Induction of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production is thought to have beneficial immunomodulatory effects in acute and chronic inflammatory disorders. In Raw 264.7 cells stimulated with lipopolysaccharide (LPS) to mimic inflammation, withaferin A inhibited LPS-induced expre...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2008.09.017

    authors: Oh JH,Lee TJ,Park JW,Kwon TK

    更新日期:2008-12-03 00:00:00

  • The selective tachykinin neurokinin 1 (NK1) receptor antagonist, GR 205,171, stereospecifically inhibits light-induced phase advances of hamster circadian activity rhythms.

    abstract::Circadian rhythms in mammals are generated by master pacemaker cells located within the suprachiasmatic nucleus of the hypothalamus. In hamsters, the suprachiasmatic nucleus contains a small collection of cells immunoreactive for substance P, the endogenous ligand of tachykinin neurokinin 1 (NK1) receptors. In additio...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2005.10.012

    authors: Gannon RL,Millan MJ

    更新日期:2005-12-19 00:00:00

  • Differing actions of beta-(2-thienyl)-gamma-aminobutyric acid in central and peripheral preparations.

    abstract::In the guinea-pig isolated ileum, beta-(2-thienyl)-gamma-aminobutyric acid (BTG; 100-500 microM) reversibly and competitively (pA2 = 4.3 +/- 0.1) antagonised the baclofen-induced (5-100 microM) depression of cholinergic twitch contractions, but not that to adenosine or morphine. By contrast, in rat neocortical slice p...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(92)90784-2

    authors: Ong J,Kerr DI,Berthelot P,Vaccher C,Flouquet N,Debaert M

    更新日期:1992-10-06 00:00:00

  • Participation by purines in the modulation of norepinephrine release by methoxamine.

    abstract::The alpha 1-receptor agonist methoxamine reduced, by a prazosin sensitive mechanism, the nerve stimulation evoked release of norepinephrine in the rat caudal artery. The effect of methoxamine was also antagonized by the purinoceptor antagonist 8-(p-sulfophenyl)theophylline suggesting an involvement of endogenous purin...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(91)90236-j

    authors: Shinozuka K,Sedaa KO,Bjur RA,Westfall DP

    更新日期:1991-01-17 00:00:00

  • Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells.

    abstract::Angiotensin-converting enzymes, ACE and ACE2, are key members of renin angiotensin system. Activation of ACE2/Ang-(1-7) pathway enhances cardiovascular protective functions of bone marrow-derived stem/progenitor cells. The current study evaluated the selectivity of ACE2 inhibitors, MLN-4760 and DX-600, and ACE and ACE...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2016.01.007

    authors: Joshi S,Balasubramanian N,Vasam G,Jarajapu YP

    更新日期:2016-03-05 00:00:00

  • The quinoxalinediones antagonise the visual firing of sustained retinal ganglion cells.

    abstract::The non N-methyl-D-aspartate (NMDA) receptor antagonists dinitroquinoxaline-2,3-dione (DNQX) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), both inhibit the visually driven response of sustained ganglion cells in the cat retina in vivo. In contrast to these findings, the potent NMDA receptor antagonist 3-[+/- )-2-ca...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(89)90483-4

    authors: Kay CD,Ikeda H

    更新日期:1989-05-19 00:00:00

  • Interaction between halothane and morphine on isolated heart muscle.

    abstract::The present study describes the effects of halothane on morphine activity in the isolated left atria of the rat. Concentration-response curves were obtained for the negative inotropic effects of morphine on electrically stimulated left atria. Morphine significantly decreased the contractile force, with an inhibitory c...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(90)90566-o

    authors: Laorden ML,Hernandez J,Carceles MD,Miralles FS,Puig MM

    更新日期:1990-01-17 00:00:00

  • Loss of beta-adrenoceptor binding sites in rat striatum following kainic acid lesions.

    abstract::Intrastriatal injection of kainic acid (5 nmoles) to rats led to severe destruction of nerve cell bodies throughout the caudate-putamen complex and an extensive proliferation of glial cells. Lesioned striata displayed a significant 23% loss of beta-adrenoceptor binding sites 21--24 days after injection of kainic acid....

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(79)90226-7

    authors: Nahorski SR,Howlett DR,Redgrave P

    更新日期:1979-12-07 00:00:00

  • Murine erythropoietic impairment induced by paclitaxel: interactions of GATA-1 and erythroid Krüppel-like transcription factors, apoptotic related proteins and erythropoietin receptor.

    abstract::Paclitaxel, an antitumoral drug, was used in a single dose (29 mg/kg i.p.) as an injury agent for inducing transient suppression of hematopoiesis in a murine experimental model during 10days. The aim of this study focuses on erythropoietin (EPO) receptor, GATA binding protein 1 (globin transcription factor 1) (GATA-1)...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2010.02.056

    authors: Aguirre MV,Todaro JS,Juaristi JA,Brandan NC

    更新日期:2010-06-25 00:00:00

  • Effects of platelet activating factor receptor antagonists on intracellular platelet activating factor function in neutrophils.

    abstract::We investigated the effects of the platelet activating factor (PAF) receptor antagonists, SM-12502 ((+)-cis-3,5-dimethyl-2-(pyridyl)- thiazolidin-4-one hydrochloride), WEB-2086 (3-(4-(2-chlorphenyl)-9-methyl-6H-thieno(3,2-f)-(1,2,4)triazolo(4, 3- a)(1,4)diazepin-2-yl)-1-(4-morpholinyl)-1-propanone) and RP-48740 (3-(3-...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0922-4106(94)90037-x

    authors: Koike H,Imanishi N,Natsume Y,Morooka S

    更新日期:1994-11-15 00:00:00

  • Psychological co-morbidities in COPD: Targeting systemic inflammation, a benefit for both?

    abstract::COPD is a chronic lung disease characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities. Furthermore, COPD is often characterized by extrapulmonary manifestations and comorbidities worsening COPD progression and quality of life. A neglected comorbidity in COPD...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejphar.2018.10.001

    authors: Pelgrim CE,Peterson JD,Gosker HR,Schols AMWJ,van Helvoort A,Garssen J,Folkerts G,Kraneveld AD

    更新日期:2019-01-05 00:00:00

  • Pharmacological analysis of the cardiac sympatho-inhibitory actions of moxonidine and agmatine in pithed spontaneously hypertensive rats.

    abstract::This study shows that in spontaneously hypertensive rats (SHR) of 14-weeks-old, the sympathetically-induced, but not noradrenaline-induced tachycardic response are higher than age-matched Wistar normotensive rats. Furthermore, in SHR the sympathetically-induced tachycardic response was: (1) unaffected by moxonidine (3...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2016.08.017

    authors: Cobos-Puc LE,Sánchez-López A,Centurión D

    更新日期:2016-11-15 00:00:00

  • Evidence for the involvement of prostaglandins in modulation of acetylcholine release from canine bronchial tissue.

    abstract::A sensitive high pressure liquid chromatography (HPLC) method was used to measure acetylcholine release from canine bronchial tissue in response to electrical stimulation. Indomethacin enhanced the efflux of acetylcholine, an effect that was reversed by the addition of prostaglandin E2 (PGE2). Prostaglandin D2 (PGD2) ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(89)90451-2

    authors: Deckers IA,Rampart M,Bult H,Herman AG

    更新日期:1989-08-29 00:00:00

  • Insulin, not glutamine dipeptide, reduces lipases expression and prevents fat wasting and weight loss in Walker 256 tumor-bearing rats.

    abstract::Cachexia is the main cause of mortality in advanced cancer patients. We investigated the effects of insulin (INS) and glutamine dipeptide (GDP), isolated or associated, on cachexia and metabolic changes induced by Walker 256 tumor in rats. INS (NPH, 40 UI/kg, sc) or GDP (1.5g/kg, oral gavage) was once-daily administer...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2017.03.010

    authors: de Morais H,de Fatima Silva F,da Silva FG,Silva MO,Graciano MFR,Martins MIL,Carpinelli ÂR,Mazucco TL,Bazotte RB,de Souza HM

    更新日期:2017-07-05 00:00:00

  • Vasopressin V(1) receptor-mediated activation of central sympatho-adrenomedullary outflow in rats.

    abstract::The present study was designed to characterize the vasopressin receptor subtype involved in the vasopressin-induced activation of the central sympatho-adrenomedullary outflow using urethane-anesthetized rats. Intracerebroventricularly (i.c.v.) administered vasopressin (0.1, 0.2 and 0.5 nmol/animal) dose-dependently el...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(02)02652-3

    authors: Okada S,Murakami Y,Nakamura K,Yokotani K

    更新日期:2002-12-13 00:00:00

  • Presynaptic depression of inhibitory postsynaptic potentials by metabotropic glutamate receptors in rat hippocampal CA1 pyramidal cells.

    abstract::The effects of the metabotropic glutamate (mGlu) receptor agonists (+/-)-trans-1-aminocyclopentane-1,3-dicarboxylic acid (trans-ACPD) or 1S,3R-ACPD on gamma-aminobutyric acid (GABA)-mediated inhibitory synaptic responses have been investigated in vitro in CA1 pyramidal cells of rat hippocampal slices. Bath application...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(95)00223-8

    authors: Jouvenceau A,Dutar P,Billard JM

    更新日期:1995-08-04 00:00:00

  • Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte.

    abstract::Pteropodine and isopteropodine are heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC, a Peruvian medicinal plant known as cat's claw. In this study, the effects of these alkaloids on the function of Ca(2+)-activated Cl(-) currents evoked by stimulation of G protein-coupled muscarinic M...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(02)01608-4

    authors: Kang TH,Matsumoto K,Tohda M,Murakami Y,Takayama H,Kitajima M,Aimi N,Watanabe H

    更新日期:2002-05-24 00:00:00

  • Capsaicin pretreatment does not inhibit the opioid withdrawal response in guinea-pigs.

    abstract::The effects of capsaicin pretreatment on withdrawal responses of guinea-pig isolated ileum to [Met5]enkephalin (ME) and morphine and on the locomotor withdrawal response of guinea-pigs following a single dose of morphine, were investigated. In vitro treatment of ileum with capsaicin, 1.5 mumol/l for 1 h, did not signi...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(88)90257-9

    authors: Chahl LA

    更新日期:1988-12-06 00:00:00

  • Impaired cyclic AMP generation in outer medullary tubules of gentamicin-treated rats.

    abstract::We have examined the effects of chronic gentamicin treatment on arginine8-vasopressin (AVP)-dependent cyclic AMP (cAMP) metabolism in rat medullary collecting tubules (oMCT) and medullary thick ascending limbs of Henle's loop (mTALH). Gentamicin attenuated AVP-stimulated cAMP accumulation to a greater extent in the mT...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(90)94186-2

    authors: Kidwell D,Subramaniam S,Ott C,Jackson B

    更新日期:1990-12-04 00:00:00

  • Comparison of several new 5-lipoxygenase inhibitors in a rat Arthus pleurisy model.

    abstract::The 5-lipoxygenase inhibitors WY-50,295 tromethamine, A-64,077, L-663,536 and ICI-207,968 were compared in a reverse passive Arthus reaction-induced pleurisy model of eicosanoid biosynthesis in the rat. When a 1 h pretreatment schedule was employed, all four inhibitors equivalently blocked leukotriene B4 (LTB4) produc...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(91)90196-w

    authors: Berkenkopf JW,Weichman BM

    更新日期:1991-01-25 00:00:00

  • A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury.

    abstract::The efficacy of a novel, nonpeptidic, caspase 3/7-selective inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (MMPSI) for reducing ischemic injury in isolated rabbit hearts or cardiomyocytes was evaluated. MMPSI (0.1-10 microM) evoked a concentration-dependent reduction in infarct size (up to 56% vs...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(02)02484-6

    authors: Chapman JG,Magee WP,Stukenbrok HA,Beckius GE,Milici AJ,Tracey WR

    更新日期:2002-12-05 00:00:00

  • Effects of protein kinase inhibitors on the stimulated neutrophil responses by degraded immunoglobulin G.

    abstract::Effects of protein kinase C inhibitors, staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride and protein tyrosine kinase inhibitors, genistein, tyrphostin and 2,5-dimethylcinnamate on the neutrophil responses stimulated by immunoglobulin G (IgG), complement C5a or platelet-activating factor...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(96)00097-0

    authors: Ahn SK,Shin YK,Kang HJ,Han ES,Lee CS

    更新日期:1996-06-13 00:00:00

  • Regulation of urokinase plasminogen activator by epigallocatechin-3-gallate in human fibrosarcoma cells.

    abstract::(-)-Epigallocatechin-3-gallate (EGCG), a main flavanol of green tea, potently suppressed the urokinase-type plasminogen activator (uPA) expression in human fibrosarcoma HT 1080 cells. EGCG induced not only the suppression of the uPA promoter activity but also the destabilization of uPA mRNA. EGCG inhibited the phospho...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2003.12.031

    authors: Kim MH,Jung MA,Hwang YS,Jeong M,Kim SM,Ahn SJ,Shin BA,Ahn BW,Jung YD

    更新日期:2004-03-08 00:00:00

  • Positive inotropic effects of adrenomedullin on rat papillary muscle.

    abstract::Adrenomedullin is a peptide recently isolated from pheochromocytoma that has vasorelaxant and long-lasting hypotensive activities. Plasma levels of adrenomedullin are elevated in patients with congestive heart failure, but the effects of adrenomedullin on the cardiac function are unclear. We, thus, investigated the ef...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(00)00011-x

    authors: Ihara T,Ikeda U,Tate Y,Ishibashi S,Shimada K

    更新日期:2000-02-25 00:00:00

  • A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level.

    abstract::A new experimental drug pirfenidone (5-methyl-1-phenyl-2-1H-pyridine-2-one) has been reported to have beneficial effects for the treatment of certain fibrotic diseases. Here, we studied the anti-inflammatory activities of pirfenidone by investigating the mechanism of its inhibitory effect on cytokine production. In RA...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(02)01758-2

    authors: Nakazato H,Oku H,Yamane S,Tsuruta Y,Suzuki R

    更新日期:2002-06-20 00:00:00

  • The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine.

    abstract::Many central stimulating drugs have a pronounced stimulatory effect on striatal and cortical activity which is associated to enhanced function of mesencephalic dopaminergic neurons. Mesencephalic KCNQ (also termed K(v)7) potassium channels suppress the basal activity of dopaminergic neurons in the substantia nigra and...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2007.05.029

    authors: Hansen HH,Andreasen JT,Weikop P,Mirza N,Scheel-Krüger J,Mikkelsen JD

    更新日期:2007-09-10 00:00:00

  • Sigma-1 receptor stimulation with fluvoxamine activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding.

    abstract::In the present study, we investigated the vasculoprotective effect of sigma-1 receptor stimulation with fluvoxamine on pressure overload hypertrophy-induced vascular injury in the thoracic aorta and defined mechanisms underlying that activity. Wistar rats underwent bilateral ovariectomy, and two weeks later were furth...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2010.10.055

    authors: Bhuiyan MS,Tagashira H,Fukunaga K

    更新日期:2011-01-15 00:00:00

  • Co-administration of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid and arachidonic acid potentiates synaptic transmission in rat hippocampal slices.

    abstract::Perfusion of the 1S,3R isomer of trans-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD, 50 microM), or arachidonic acid (10 microM), for 5 min produced only depression of the field excitatory postsynaptic potential recorded in the CA1 region of rat hippocampal slices from which the CA3 region had been removed. However...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(93)90919-9

    authors: Collins DR,Davies SN

    更新日期:1993-08-24 00:00:00

  • The effects of adenosine triphosphate and related purines on arterial resistance vessels in vitro and in vivo.

    abstract::The distribution of P2-purinoceptors in pre-capillary resistance vessels was studied in vitro, using Krebs perfused rabbit ears and in vivo, in autoperfused hindquarters, intestinal and renal vasculatures of pentobarbitone anaesthetised cats. ATP (10(-10)-10(-6) mol i.a.) caused dose-dependent vasodilatation which, in...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(89)90834-0

    authors: Taylor EM,Parsons ME,Wright PW,Pipkin MA,Howson W

    更新日期:1989-02-28 00:00:00