Abstract:
:The positive chronotropic effect of angiotensin II was studied on the isolated spontaneously beating cat right atria. Angiotensin II and prostacyclin produced similar positive chronotropic and inotropic effects which were not affected by beta-adrenoceptor and histamine H2-receptor blockers. [Sar1,Ile8] angiotensin II, however, inhibited the positive chronotropic and inotropic responses to angiotensin II without altering that to prostacyclin, noradrenaline and histamine. Nicotine completely abolished the positive chronotropic action of angiontensin II without altering its positive inotropic effect. Nicotine failed to abolish the effects of prostacyclin, noradrenaline and histamine on the rate and contractility. These results were taken as evidence that the angiotensin II-induced increase in heart rate is probably mediated through the increase of prostacyclin biosynthesis in the isolated cat right atria.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Türker RKdoi
10.1016/0014-2999(82)90260-6subject
Has Abstractpub_date
1982-09-24 00:00:00pages
271-5issue
3-4eissn
0014-2999issn
1879-0712pii
0014-2999(82)90260-6journal_volume
83pub_type
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journal_title:European journal of pharmacology
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