The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor.

abstract：:This study investigated the effect of the platelet-activating factor (PAF) receptor antagonist, PCA 4248, on the rat pleurisy caused by PAF, serotonin, bradykinin, histamine or allergen. The pleurisy was assessed by measuring liquid extravasation and leucocyte infiltration. Oral pretreatment with PCA 4248 (2.5-20 mg/k...

journal_title：European journal of pharmacology

authors： Martins MA,Lima MC,Bozza PT,Faria Neto HC,Silva PM,Sunkel CE,Cordeiro RS

更新日期：1993-06-11 00:00:00

abstract：:Rat aortic smooth muscle rings without endothelial cells were subjected to alpha 1-adrenoceptor stimulation. We measured the contractile state of the smooth muscle cells and the formation of inositol phosphates (InsPs) on receptor stimulation. Using different extracellular calcium-containing solutions (2.5 mM, 0.1 mM ...

journal_title：European journal of pharmacology

authors： Manolopoulos VG,Pipili-Synetos E,Den Hertog A,Nelemans A

更新日期：1991-05-25 00:00:00

abstract：:We have reported previously that the dipeptidyl peptidase IV inhibitor Ile-Pro-Ile had an antihyperalgesic action in rats when given intrathecally in the carrageenan-induced hyperalgesia, as detected by the Randall-Selitto test. Vildagliptin, a non-peptide inhibitor of the same enzyme, which is already on the market a...

journal_title：European journal of pharmacology

authors： Király K,Lambeir AM,Szalai J,Szentirmay A,Luyten W,Barna I,Puskár Z,Kozsurek M,Rónai AZ

更新日期：2011-01-10 00:00:00

abstract：:We have characterized the tachykinin NK(2) receptor-mediated contraction and vectorial ion transport responses in the muscularis mucosae and mucosa of the rat isolated distal colon, respectively. The tachykinin NK(2) receptor-selective antagonist nepadutant (c([(beta-D-GlcNAc)Asn-Asp-Trp-Phe-Dpr-Leu]c(2beta-5beta))) p...

journal_title：European journal of pharmacology

authors： Patacchini R,Cox HM,Ståhl S,Tough IR,Maggi CA

更新日期：2001-03-01 00:00:00

abstract：:In adult male rats, injection of TRH into a lateral ventricle of the brain 5 min prior to pentobarbital (PB) administration caused a significant dose-related inhibition of prolactin (PRL) release, in doses ranging from 500 to 5 ng. Among 8 TRH analogues devoid of thyrotropin-releasing activity, 6 were found to signifi...

journal_title：European journal of pharmacology

authors： Taché Y,Ruisseau PD,Ducharme JR,Collu R

更新日期：1977-10-15 00:00:00

abstract：:The use of "multimodal" combination analgesic therapies or novel single molecules possessing multiple analgesic targets is becoming increasingly attractive. In previous experiments we showed that a substance P antagonist injected intrathecally potentiated the antinociceptive effects of potent opioid receptor agonist, ...

journal_title：European journal of pharmacology

authors： Bonney IM,Foran SE,Marchand JE,Lipkowski AW,Carr DB

更新日期：2004-03-19 00:00:00

abstract：:Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria. It is a ligand for Toll-like receptor 4 (TLR4), which plays an essential role in innate immunity. Macrophages and dendritic cells exposed to LPS overproduce proinflammatory mediators, leading to septic shock. In this study, we scr...

journal_title：European journal of pharmacology

authors： Sugiyama K,Muroi M,Tanamoto K

更新日期：2008-10-10 00:00:00

abstract：:This study determined the in vitro functional profile of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate (OPC-14523) at rat and human serotonin (5-HT) 5-HT1A receptors and binding affinity of OPC-14523 at human frontocortical 5-HT1A receptors. OPC-14523 (1 microM...

journal_title：European journal of pharmacology

authors： Jordan S,Chen R,Koprivica V,Hamilton R,Whitehead RE,Tottori K,Kikuchi T

更新日期：2005-07-11 00:00:00

abstract：:Studies have demonstrated that long-term opioid treatment leads to an increased sensitivity to painful (hyperalgesia) or normally innocuous (allodynia) stimuli. The molecular mechanisms that lead to paradoxical pain sensitization upon chronic opioid treatment are not completely understood. Enhanced excitatory pain neu...

journal_title：European journal of pharmacology

authors： Tumati S,Milnes TL,Yamamura HI,Vanderah TW,Roeske WR,Varga EV

更新日期：2008-12-28 00:00:00

abstract：:The binding of the bisquaternary muscarine receptor antagonist heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)-ammonium bromide (C7/3-phth) was investigated at a number of cholinergic binding sites using (-)-[3H]nicotine, [3H]pirenzepine and (-)-[3H]quinuclidinyl benzilate ([3H]QNB) in both central and peripheral tissu...

journal_title：European journal of pharmacology

authors： Christopoulos A,Loiacono R,Mitchelson F

更新日期：1993-06-15 00:00:00

abstract：:An excess of lipids may accumulate in the kidney in conditions such as diabetes and hypertension, and can potentially cause renal injury. We previously reported that an infusion of angiotensin II into a rat induced deposition of lipids in the renal tubular epithelial cells. Here we have examined the effect of pioglita...

journal_title：European journal of pharmacology

authors： Sakamoto A,Hongo M,Saito K,Nagai R,Ishizaka N

更新日期：2012-05-05 00:00:00

abstract：:Ten beta-adrenoceptor blocking drugs varying in lipophilicity and beta-adrenoceptor blocking potency were examined for inhibitory effects on synaptosomal [3H]noradrenaline uptake. All compounds produced a concentration-dependent inhibition of noradrenaline uptake, but were at least one order of magnitude less potent t...

journal_title：European journal of pharmacology

authors： Street JA,Walsh A

更新日期：1984-07-13 00:00:00

abstract：:The release of endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) was investigated in synaptosomes prepared from various regions of the rat brain. The basal release of Asp, Glu and GABA from various regions was 12-35, 24-107 and 15-43 pmol/min per mg protein, respectively. Exposure ...

journal_title：European journal of pharmacology

authors： Kamisaki Y,Hamahashi T,Hamada T,Maeda K,Itoh T

更新日期：1992-06-24 00:00:00

abstract：:Acute administration of delta 9-tetrahydrocannabinol (THC) (50 mg/kg) at puberty (35-40 days) significantly (P less than 0.05) reduced Ca2+ ATPase activity in hypothalamic plasma membranes but increased, although not significantly, enzyme activity in hypothalamic tissue obtained from adult mice. In contrast, testicula...

journal_title：European journal of pharmacology

authors： Dalterio SL,Bernard SA,Esquivel CR

更新日期：1987-05-07 00:00:00

abstract：:NO plays a key role in the pathological mechanisms of articular diseases. As cytoskeletal proteins are responsible for the polymerization, stabilization, and dynamics of the cytoskeleton network, we investigated whether cytoskeletal proteins are the intracellular pathological targets of NO. We aimed at clarifying whet...

journal_title：European journal of pharmacology

authors： Kao XB,Chen Q,Gao Y,Fan P,Chen JH,Wang ZL,Wang YQ,Chen YN,Yan YP

更新日期：2018-04-05 00:00:00

abstract：:The evidence suggests that stimulation of brain noradrenergic neurons plays an inhibitory role in rat mouse-killing (muricidal) aggression. Anxiolytic benzodiazepines inhibit locus coeruleus activity and previous data showed that chlordiazepoxide was capable of antagonizing the locus coeruleus-mediated suppression of ...

journal_title：European journal of pharmacology

authors： Kozak W,Valzelli L,Garattini S

更新日期：1984-10-15 00:00:00

abstract：:Inhibition of local cortisol regeneration from circulating cortisone by blocking 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been shown to ameliorate the risk factors associated with the metabolic syndrome. Chronic modulation of glucocorticoid homeostasis may result in hypothalamic-pituitary-adrenal (HPA) axis s...

journal_title：European journal of pharmacology

authors： Hamilton BS,Schoelch C,Schuler-Metz A,Krosky P,Lala DS,Claremon DA,McGeehan GM

更新日期：2016-10-15 00:00:00

abstract：:The formation of epidural fibrosis adjacent to the dura mater is a complex multi-step process that is associated with a marked reduction in tissue cellularity and the excessive deposition of extracellular matrix components. Extensive epidural fibrosis is a major cause of post-laminectomy syndrome. Decorin strongly inh...

journal_title：European journal of pharmacology

authors： Turkoglu E,Dinc C,Tuncer C,Oktay M,Serbes G,Sekerci Z

更新日期：2014-02-05 00:00:00

abstract：:Angiotensin AT1 receptor antagonists represent a novel class of cardiovascular drugs. In conscious, normotensive rats, irbesartan ((2-n-butyl-3-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl) methyl]-1,3-diaza-spiro[4,4]non) and losartan ((2 n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl -4-yl) methyl] imid...

journal_title：European journal of pharmacology

authors： Culman J,von Heyer C,Piepenburg B,Rascher W,Unger T

更新日期：1999-02-19 00:00:00

abstract：:Diabetic nephropathy (DN) is a major cause of end-stage renal disease and one of the most severe diabetic complications. However, there is lack of effective treatments for DN and the underlying mechanisms of the renal injury remain unclear. In current study, we evaluated the effects of silibinin on DN and further expl...

journal_title：European journal of pharmacology

authors： Liu Y,Ye J,Cao Y,Zhang R,Wang Y,Zhang S,Dai W,Ye S

更新日期：2019-02-15 00:00:00

abstract：:Sibutramine was formerly marketed as an anti-obesity agent. The current study investigated the relationships between monoamine reuptake site occupancy for sibutramine and both its antidepressant-like efficacy and thermogenic effects. Sibutramine's effects on locomotor activity (LMA) and food intake were also evaluated...

journal_title：European journal of pharmacology

authors： Li YW,Langdon S,Pieschl R,Strong T,Wright RN,Rohrbach K,Lelas S,Lodge NJ

更新日期：2014-08-15 00:00:00

abstract：:Homovanillic acid (HVA) was measured in rat caudate and pre-frontal cortex 3 h following a single dose of a variety of neuroleptics. Thioridazine, haloperidol, fluphenazine, and metoclopramide increased HVA levels in caudate more than in pre-frontal cortex; whereas sulpiride and clozapine produced greater increases in...

journal_title：European journal of pharmacology

authors： Bowers MB Jr

更新日期：1984-03-16 00:00:00

abstract：:The aim was to find whether the chloride channel blocker, picrotoxin, at subconvulsant doses could affect the activity of imipramine or desipramine in the 'forced swimming' test with rats. It was found that picrotoxin enhanced the anti-immobility effects of imipramine and desipramine whereas open field activity remain...

journal_title：European journal of pharmacology

authors： Fernández-Teruel A,Escorihuela RM,Boix F,Tobeña A

更新日期：1990-05-31 00:00:00

abstract：:The cardiovascular and biochemical responses during acute oxidative stress induced by D,L-buthionine-(S,R)-sulfoximine (BSO) were investigated in Sprague-Dawley rats. Mean arterial pressure, heart rate and vascular reactivity were measured after subcutaneous injection of BSO (4 mmol/kg). Control rats received saline. ...

journal_title：European journal of pharmacology

authors： Ganafa AA,Socci RR,Eatman D,Silvestrova N,Abukhalaf IK,Bayorh MA

更新日期：2002-11-15 00:00:00

abstract：:A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healthy volunteers. The equilibrium dissociation constant for binding by [3H]PK 1...

journal_title：European journal of pharmacology

authors： Gavish M,Weizman A,Karp L,Tyano S,Tanne Z

更新日期：1986-02-18 00:00:00

abstract：:The effects of prolactin on animal behavior include the stimulation of novelty-induced grooming in rats. This effect has been demonstrated in hyperprolactinaemic animals bearing pituitary homografts under the kidney capsule or after intracerebroventricular (i.c.v.) administration of prolactin. Since plasma prolactin l...

journal_title：European journal of pharmacology

authors： Drago F,Lissandrello CO

更新日期：2000-09-29 00:00:00

abstract：:Poly (ADP-ribose) polymerase (PARP), a nuclear enzyme activated by strand breaks in DNA, plays an important role in the colon injury associated with experimental colitis. The aim of the present study was to examine the effects of 3-aminobenzamide (3-AB), an inhibitor of PARP activity, in the development of acute pancr...

journal_title：European journal of pharmacology

authors： Mazzon E,Genovese T,Di Paola R,Muià C,Crisafulli C,Malleo G,Esposito E,Meli R,Sessa E,Cuzzocrea S

更新日期：2006-11-07 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) may have a pivotal role in the genesis of mechanical inflammatory hyperalgesia in rats and in the nociceptive writhing response in mice. Thalidomide has been shown to selectively inhibit TNF-alpha production. We therefore investigated the effect of thalidomide on these responses...

journal_title：European journal of pharmacology

authors： Ribeiro RA,Vale ML,Ferreira SH,Cunha FQ

更新日期：2000-03-10 00:00:00

abstract：:The anticonvulsant effect of cannabinoids has been shown to be mediated through activation of the cannabinoid CB(1) receptor. This study was initiated to evaluate the effects of endogenously occurring cannabinoids (endocannabinoids) on seizure severity and threshold. The anticonvulsant effect of the endocannabinoid, a...

journal_title：European journal of pharmacology

authors： Wallace MJ,Martin BR,DeLorenzo RJ

更新日期：2002-10-11 00:00:00

abstract：:Although previous studies have demonstrated that Ginkgo biloba extract has modest effects in the improvement of memory and cognitive function of the Alzheimer's disease patients, the mechanism(s) underlying its beneficial effects remain(s) unclear. In this study, the effect of ginkgolide B, one of the major constituen...

journal_title：European journal of pharmacology

authors： Wang SJ,Chen HH

更新日期：2005-05-09 00:00:00