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Tryptase-induced airway microvascular leakage in guinea pigs: involvement of tachykinins and leukotrienes.

Abstract：

:Tryptase, a serine protease synthesized by and stored in mast cells, is implicated as an important mediator in the pathogenesis of airway inflammation. In this study, tryptase was evaluated for its ability to induce microvascular leakage into the airways of guinea pigs. Dose- and time-dependent increases in airway microvascular leakage were produced by intratracheal tryptase (0.3-3 microg). Intratracheal tryptase (3-30 microg) had no effect on airway tone as measured by pulmonary insufflation pressure. Tryptase-induced airway microvascular leakage was partially blocked by the tachykinin NK1 receptor antagonist CP 99994 [(+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine] and an inhibitor of leukotriene formation SCH 37224 (1-(1,2-dihydro-4-hydroxy-2-oxo-1-phenyl-1,8-naphthyridin-2-yl)pyrrolidinium, hydroxide inner salt). Neither CP 99994 nor SCH 37224 inhibited tryptase proteolytic activity in-vitro. Pretreatment of guinea pigs with histamine H1 receptor antagonists or a tachykinin NK2 receptor antagonist had no affect on the airway microvascular leakage induced by tryptase. It is speculated that tryptase may be important in the pathogenesis of airway inflammation, particularly in disorders that involve increased airway microvascular leakage such as asthma.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Greenfeder S,Sehring S,McHugh N,Corboz M,Rivelli M,Anthes JC,Billah M,Egan RW,Chapman RW

doi

10.1016/s0014-2999(01)00960-8

keywords:

subject

Has Abstract

pub_date

2001-05-11 00:00:00

pages

261-7

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(01)00960-8

journal_volume

419

pub_type

杂志文章

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