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L-cysteine augments the vasorelaxation induced by sodium nitrite and SIN-1 but not that due to acetylcholine.

Abstract：

:The effects of 1 mM L-cysteine on sodium nitrite-, 3-morpholinosydnonimine (SIN-1)- and acetylcholine-induced relaxation and cyclic GMP accumulation were studied in isolated noradrenaline-precontracted rat mesenteric arterial rings. L-Cysteine augmented the relaxation and cyclic GMP increase induced by sodium nitrate and SIN-1 but not those induced by acetylcholine. The effects of L-cysteine on relaxation were independent of the presence of intact endothelium. The results suggest that L-cysteine protects exogenously released nitric oxide.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Arvola P,Pörsti I,Vuorinen P,Huhtala H,Metsä-Ketelä T,Vapaatalo H

doi

10.1016/0014-2999(92)90133-o

keywords:

subject

Has Abstract

pub_date

1992-04-22 00:00:00

pages

289-92

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(92)90133-O

journal_volume

214

pub_type

杂志文章

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