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Molecular orbital study on the glutathione-dependent detoxication of ozonides.

Abstract：

:The present paper describes a theoretical study on the mechanism underlying the reaction of cellular glutathione (GSH) with polyunsaturated fatty acid ozonides. The reaction can be catalyzed by glutathione S-transferases and leads to detoxication of the ozonides. Semi-empirical molecular orbital computer calculations suggest that the reaction of glutathione with ozonides involves a nucleophilic attack at one of the carbon atoms of the ozonide ring, instead of at one of the peroxidic oxygen atoms of the ozonide ring. This implies a mechanism different from that of the glutathione S-transferase-mediated reaction with hydroperoxides, previously proposed for the glutathione-dependent detoxication of fatty acid ozonides.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Hempenius RA,de Vries J,Rietjens IM

doi

10.1016/0926-6917(92)90031-7

keywords:

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

207-11

issue

4

eissn

0014-2999

issn

1879-0712

journal_volume

228

pub_type

杂志文章

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