Bradykinin and angiotensin II inhibit neurotransmission in rabbit ear artery by releasing prostanoids.

abstract：:The effects of N- and L-type voltage operated calcium channel (VOCC) antagonists were examined on the bronchoconstriction induced by vagal stimulation in artificially respired guinea-pigs. Vagal stimulation produced a reproducible and consistent bronchoconstrictor response which corresponded to an increase in pulmonar...

journal_title：European journal of pharmacology

authors： Boot JR,Bond A

更新日期：1992-08-14 00:00:00

abstract：:The tolerance to analgesia and dependence liability of dihydroetorphine following topical application were investigated in hairless rats with and without formalin-induced inflammation. The analgesic effect of dihydroetorphine (s.c.) was 4600- to 7200-fold more potent than that of morphine. In non-inflamed rats, the an...

journal_title：European journal of pharmacology

authors： Ohmori S,Fang L,Kawase M,Saito S,Morimoto Y

更新日期：2001-07-06 00:00:00

abstract：:This study investigates the relationship between the rate of phorbol ester-induced contraction of intact rat aorta and protein kinase C activation, as assessed by the translocation of protein kinase C from the cytosolic to the particulate fraction. Aorta was exposed to Ca(2+)-free physiologic salt solution prior to ph...

journal_title：European journal of pharmacology

authors： Bazan E,Campbell AK,Rapoport RM

更新日期：1995-08-15 00:00:00

abstract：:The activity of angiotensin-converting enzyme in rat choroid plexus was higher than that of any other organ, being 6--7 times higher than that in lung and more than 50 times higher than in any other region of brain. Rabbit choroid plexus also had high activity of enzyme while that of human choroid plexus was relativel...

journal_title：European journal of pharmacology

authors： Arregui A,Iversen LL

更新日期：1978-11-01 00:00:00

abstract：:Recently, down-regulation of vascular endothelial growth factor (VEGF) in the heart was suggested as a potential molecular explanation for the increased risk of cardiovascular morbidity and mortality in patients with diabetes. Increased endothelin-1 production is reported in diabetes. Here, we report that down-regulat...

journal_title：European journal of pharmacology

authors： Jesmin S,Miyauchi T,Goto K,Yamaguchi I

更新日期：2006-08-07 00:00:00

abstract：:The present study was carried out to clarify the role of nonselective cation channels as a Ca2+ entry pathway in the contraction and the increase in [Ca2+]i induced by endothelin- in endothelium-denuded rat thoracic aorta rings, and their suppression by nitric oxide (NO). In Ca2+-free medium, the endothelin-1-induced ...

journal_title：European journal of pharmacology

authors： Zhang XF,Komuro T,Miwa S,Minowa T,Iwamuro Y,Okamoto Y,Ninomiya H,Sawamura T,Masaki T

更新日期：1998-07-10 00:00:00

abstract：:The affinity of LY-171555 (quinpirole) and BHT-920 for both states of rat striatal dopamine D-1 and D-2 receptors was determined. Although these drugs have different pharmacological effects in experimental animals, we found that they had similar affinities for both D-1 and D-2 receptors. ...

journal_title：European journal of pharmacology

authors： Ferré S,Guix T,Sallés J,Cuffí L,Badia A,Casas M

更新日期：1989-07-18 00:00:00

abstract：:We review a large volume of literature concerning mathematical models of cancer therapy, oriented towards optimization of treatment protocols. The review, although partly idiosyncratic, covers such major areas of therapy optimization as phase-specific chemotherapy, antiangiogenic therapy and therapy under drug resista...

journal_title：European journal of pharmacology

authors： Swierniak A,Kimmel M,Smieja J

更新日期：2009-12-25 00:00:00

abstract：:Some effects of Org GC 94 (1,3,4,14b-tetrahydro-2,7-dimethyl-2H-dibenzo[b,f]pyrazino[1,2-d][1,4]oxazepine maleate) on human platelets have been investigated. Without pretreatment with ADP, 5-HT-induced aggregation of humam platets was completely inhibited by 2.5 x 10(-8) M of Org GC 94. Aggregation triggered by noradr...

journal_title：European journal of pharmacology

authors： Bhargava N,Matthijsen R,Schönbaum E

更新日期：1977-04-07 00:00:00

abstract：:Effects of local anesthetics and structurally related drugs on the glibenclamide-sensitive K+ currents evoked by Y-26763 (a K+ channel opener) were investigated in native Xenopus oocytes. The K+ current induced by Y-26763 (100 microM) was reversibly suppressed by all six local anesthetics tested in a concentration-dep...

journal_title：European journal of pharmacology

authors： Yoneda I,Sakuta H,Okamoto K,Watanabe Y

更新日期：1993-11-15 00:00:00

abstract：:Population spikes associated with the paired pulse ratio protocol were used to measure the presynaptic inhibition of corticostriatal transmission caused by mu-opioid receptor activation. A 1 microM of [D-Ala(2), N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO), a selective mu-opioid receptor agonist, enhanced paired pulse fa...

journal_title：European journal of pharmacology

authors： Barral J,Mendoza E,Galarraga E,Bargas J

更新日期：2003-02-21 00:00:00

abstract：:CysLT1 receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT2 receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs and use this mod...

journal_title：European journal of pharmacology

authors： Sekioka T,Kadode M,Yonetomi Y,Kamiya A,Fujita M,Nabe T,Kawabata K

更新日期：2017-01-05 00:00:00

abstract：:Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+) channels are key regulators of bladder smooth muscle tone and thus may play a role in this altered phasic activity. In...

journal_title：European journal of pharmacology

authors： Vahabi B,Lawson K,McKay NG,Sellers DJ

更新日期：2011-06-25 00:00:00

abstract：:Arteries were isolated from male DBA/2 mice and mounted on a small vessel wire myograph for isometric recording. Responses to exogenous noradrenaline were inhibited with high affinity by prazosin (pKB, 9.3) and 5-methyl-urapidil (pKB, 9.2) and with low affinity by 8-[2-[4-(2-methoxyphenyl)-1 piperazinyl]ethyl]-8-azasp...

journal_title：European journal of pharmacology

authors： Zacharia J,Hillier C,Macdonald A

更新日期：2004-10-25 00:00:00

abstract：:With age an increase in prostatic smooth muscle tone mediated by α1L-adrenoceptors contributes to the lower urinary tract symptoms associated with benign prostatic hyperplasia. Current treatments for benign prostatic hyperplasia include α1-adrenoceptor antagonists which inhibit smooth muscle contraction. However, musc...

journal_title：European journal of pharmacology

authors： White CW,Short JL,Ventura S

更新日期：2013-12-05 00:00:00

abstract：:Rats were treated with ethanol in the drinking fluid 2 X 1 h daily for 83 weeks. [3H]Muscimol, [3H]quinuclidinyl benzilate ( [3H]QNB) and [3H]nicotine binding was measured in selected brain areas 7, 14 and 21 days after withdrawal of ethanol. A significant increase (P less than 0.05) when compared to controls was foun...

journal_title：European journal of pharmacology

authors： Nordberg A,Wahlström G,Eriksson B

更新日期：1985-09-24 00:00:00

abstract：:We investigated the relationship between tension development and the cytosolic free Ca2+ level ([Ca2+]i) on exposure of the endothelium-denuded isolated rat aorta to palmitoyl-L-alpha-lysophosphatidylcholine. Lysophosphatidylcholine concentration-dependently induced a gradual increase in [Ca2+]i. Application of 10(-4)...

journal_title：European journal of pharmacology

authors： Suenaga H,Kamata K

更新日期：1999-08-06 00:00:00

abstract：:An unbiased place preference conditioning procedure was used to examine the role of delta-opioid receptors in mediating the aversive effects of opioid withdrawal. Rats were implanted s.c. with two pellets each containing placebo or 75 mg morphine. Single-trial conditioning sessions with saline and the opioid receptor ...

journal_title：European journal of pharmacology

authors： Funada M,Schutz CG,Shippenberg TS

更新日期：1996-04-04 00:00:00

abstract：:The evidence suggests that stimulation of brain noradrenergic neurons plays an inhibitory role in rat mouse-killing (muricidal) aggression. Anxiolytic benzodiazepines inhibit locus coeruleus activity and previous data showed that chlordiazepoxide was capable of antagonizing the locus coeruleus-mediated suppression of ...

journal_title：European journal of pharmacology

authors： Kozak W,Valzelli L,Garattini S

更新日期：1984-10-15 00:00:00

abstract：:The effects of MCI-154, a cardiotonic agent which has direct effects on cardiac myofilaments, on postischemic contractile dysfunction were studied in dog heart subjected to a 30-min occlusion of the left anterior descending coronary artery followed by reperfusion, and compared with the effects of milrinone and dobutam...

journal_title：European journal of pharmacology

authors： Abe Y,Kitada Y,Narimatsu A,Tobe A

更新日期：1991-01-10 00:00:00

abstract：:We investigated the acute and chronic effects of alpha 2-adrenoceptor and muscarinic receptor agonists on dihydropyridine-sensitive voltage-dependent Ca2+ channels in spinal cord-dorsal root ganglion cocultures. Clonidine and oxotremorine inhibited the voltage-dependent Ca2+ influx (42 +/- 2% and 35 +/- 6% with 100 mi...

journal_title：European journal of pharmacology

authors： Nah SY,Attali B,Vogel Z

更新日期：1993-01-04 00:00:00

abstract：:Inhibition of interleukin-6 (IL-6) holds significant promise as a therapeutic approach for triple negative breast cancer (TNBC). We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. We have identified a more potent derivative of C10 termed COB-141. In the present wo...

journal_title：European journal of pharmacology

authors： Noori MS,O'Brien JD,Champa ZJ,Deosarkar SP,Lanier OL,Qi C,Burdick MM,Schwartz FL,Bergmeier SC,McCall KD,Goetz DJ

更新日期：2017-05-15 00:00:00

abstract：:Presynaptic cholinergic markers could be used for estimating the integrity of the cholinergic systems in the human brain with brain imaging techniques such as Single-photon emission computed tomography (SPECT). Vesamicol, an inhibitor of the vesicular acetylcholine transporter, and some of its derivatives have been su...

journal_title：European journal of pharmacology

authors： Custers FG,Leysen JE,Stoof JC,Herscheid JD

更新日期：1997-11-05 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is extensively distributed in primary afferent sensory nerves, including those innervating the genitourinary tract. Capsaicin can stimulate the release of CGRP from intracellular stores of these nerves, but this phenomenon has not been investigated in-depth in isolated preparatio...

journal_title：European journal of pharmacology

authors： Sheykhzade M,Gupta S,Sørensen T,Sørensen OA,Koch H,Boonen HC,Back O,Fjalland B

更新日期：2011-09-30 00:00:00

abstract：:The protective potency of ischemic preconditioning decreases with increasing age. A key step in ischemic preconditioning is the opening of mitochondrial Ca(2+) sensitive K(+) (mK(Ca)) channels, which causes mild uncoupling of mitochondrial respiration. We hypothesized that aging reduces the effects of mK(Ca) channel o...

journal_title：European journal of pharmacology

authors： Heinen A,Winning A,Schlack W,Hollmann MW,Preckel B,Frässdorf J,Weber NC

更新日期：2008-01-14 00:00:00

abstract：:The influence of the delta-opioid receptor antagonist naltrindole upon sensitization to the locomotor activating effects of cocaine was assessed. Activity in response to a challenge dose of cocaine (20 mg/kg, i.p.) was significantly increased in rats which had received cocaine (20 mg/kg, i.p.) once daily for 3 days as...

journal_title：European journal of pharmacology

authors： Heidbreder C,Goldberg SR,Shippenberg TS

更新日期：1993-10-19 00:00:00

abstract：:Approximately 3% of the world׳s population suffers from chronic infections with hepatitis C virus (HCV). Although current treatment regimes are capable of effectively eradicating HCV infection from these patients, the cost of these combinations of direct-acting antivirals are prohibitive. Approximately 80% of untreate...

journal_title：European journal of pharmacology

authors： Douglas DN,Kneteman NM

更新日期：2015-07-15 00:00:00

abstract：:A close relationship between the renin-angiotensin system and the pathophysiology of diabetic retinopathy has been suggested, several angiotensin II type 1 receptor (angiotensin AT1 receptor) antagonists being effective in animal models. Therefore, we examined the efficacy of an angiotensin AT1 receptor antagonist, ol...

journal_title：European journal of pharmacology

authors： Nakamura H,Inoue T,Arakawa N,Shimizu Y,Yoshigae Y,Fujimori I,Shimakawa E,Toyoshi T,Yokoyama T

更新日期：2005-04-11 00:00:00

abstract：:The effect of propionyl-L-carnitine, an analogue of L-carnitine, and insulin on the oscillatory potentials of the electroretinogram was determined in rats with streptozotocin-induced diabetes. Propionyl-L-carnitine was administered at a daily dose of 0.5 g/kg by gavage for 4 weeks, while other rats were treated with s...

journal_title：European journal of pharmacology

authors： Hotta N,Koh N,Sakakibara F,Nakamura J,Hamada Y,Hara T,Fukasawa H,Kakuta H,Sakamoto N

更新日期：1996-09-12 00:00:00

abstract：:2-Arachidonylglycerol (2-AG) inhibits the production in vitro of tumor necrosis factor-alpha (TNF-alpha) by mouse macrophages, as well as in mice. It has no effect on the production of nitric oxide (NO). The effect on TNF-alpha is enhanced when 2-AG is administered together with 2-linoleylglycerol (2-Lino-G) and 2-pal...

journal_title：European journal of pharmacology

authors： Gallily R,Breuer A,Mechoulam R

更新日期：2000-10-06 00:00:00