Effects of amiloride on the neurally mediated contraction of rat mesenteric artery.

abstract：:In recent years, the pilocarpine model of temporal lobe epilepsy has become the most popular and widely used rodent model of this common and difficult-to-treat type of epilepsy. In this model, the cholinomimetic convulsant pilocarpine is used to induce a status epilepticus, which is followed by hippocampal damage and ...

journal_title：European journal of pharmacology

authors： Müller CJ,Bankstahl M,Gröticke I,Löscher W

更新日期：2009-10-01 00:00:00

abstract：:This paper reports the in vitro and in vivo characterisation of a nonpeptide, orally active, vasopressin V(1A) and V(2) receptor antagonist, YM087 (methyl-1,4,5,6-tetrahydroimidazo[4, 5-d][1]benzoazepine-6-carbonyl)-2-phenylbenzanilide monohydrochloride) in the rat. YM087 dose dependently displaced the vasopressin V(1...

journal_title：European journal of pharmacology

authors： Risvanis J,Naitoh M,Johnston CI,Burrell LM

更新日期：1999-09-17 00:00:00

abstract：:Characteristics of [3H]flunitrazepam ([3H]FLU) binding to cortical and cerebellar membrane receptors were examined following chronic (six days) administration of phenobarbital (PB) to C57B1 mice. Following PB treatment, the number of [3H]FLU binding sites (Bmax) was significantly reduced in both cerebral cortex and in...

journal_title：European journal of pharmacology

authors： Liljequist S,Garrett KM,Tabakoff B

更新日期：1984-08-17 00:00:00

abstract：:The aim of this study was to correlate mineralocorticoid action and steroid structure. Inasmuch as Na(+) retention follows a parabolic dose-response curve for most pregnanesteroids, the second-order coefficient of the function was used as a representative factor for this bipartite biological effect. The C(3)=O/D angle...

journal_title：European journal of pharmacology

authors： Piwien-Pilipuk G,Kanelakis KC,Galigniana MD

更新日期：2002-11-15 00:00:00

abstract：:Unilateral ureteral obstruction (UUO) is a well-established method to study interstitial fibrosis of the kidney. In this study, we investigated the effects of a calcium channel blocker, amlodipine, on UUO-induced renal interstitial fibrosis in mice. UUO significantly increased the fibrotic area in the obstructed kidne...

journal_title：European journal of pharmacology

authors： Honma S,Nakamura K,Shinohara M,Mitazaki S,Abe S,Yoshida M

更新日期：2016-06-05 00:00:00

abstract：:The effects of a serotonin (5-HT) releasing drug, p-chloroamphetamine, on plasma glucose levels were investigated in rats. p-Chloroamphetamine elicited a significant hyperglycemia. The hyperglycemic effects of p-chloroamphetamine were completely prevented by the 5-HT synthesis inhibitor, p-chlorophenylalanine. Prior a...

journal_title：European journal of pharmacology

authors： Yamada J,Sugimoto Y,Yoshikawa T

更新日期：1998-10-23 00:00:00

abstract：:Considerable evidence has appeared recently connecting the mechanism of action of some antidepressant drugs with the inhibition of the enzymes responsible for enkephalin degradation. Imipramine in vitro inhibits the enkephalin-degrading aminopeptidase MII and interacts with the enzyme in a mixed competitive-noncompeti...

journal_title：European journal of pharmacology

authors： Gallego M,Casis L,Casis O

更新日期：1998-10-30 00:00:00

abstract：:The role of substance P in the cerebral parenchymal circulation was examined in 19 anesthetized cats. The local cerebral blood volume in the temporoparietal cortex was measured by our photoelectric method. Cerebral blood volume reflects the cumulative dimensions of the parenchymal microvessels. Intravenous injection o...

journal_title：European journal of pharmacology

authors： Kobari M,Tomita M,Tanahashi N,Yokoyama M,Takao M,Fukuuchi Y

更新日期：1996-12-19 00:00:00

abstract：:Sodium was measured in rat pancreatic islet exposed to tolbutamide, glipizide, diazoxide or sulfisomidine. When added to a medium with physiologically balanced cations these sulphonamides induced a significant rise of the islet content of sodium. The insulin-releasing compounds, tolbutamide and glipizide, had effects ...

journal_title：European journal of pharmacology

authors： Ali L,Wesslén N,Hellman B

更新日期：1988-12-13 00:00:00

abstract：:The aim of the present study was to further characterize [3H]clonidine binding in the ventrolateral medulla of the human brainstem, the region involved in the vasodepressor effect of imidazoline drugs of the clonidine type. Under basal conditions, [3H]clonidine can bind both to the imidazoline receptors and to the alp...

journal_title：European journal of pharmacology

authors： Bricca G,Greney H,Zhang J,Dontenwill M,Stutzmann J,Belcourt A,Bousquet P

更新日期：1994-01-01 00:00:00

abstract：:Concentration-relaxation curves for pinacidil and cromakalim were obtained in isolated guinea-pig tracheas contracted by histamine. Pinacidil produced complete relaxation with an EC50 value of 2.8 microM. The antidiabetic sulfonylurea, glibenclamide (0.1, 1, 10 microM), caused concentration-dependent rightward shifts ...

journal_title：European journal of pharmacology

authors： Nielsen-Kudsk JE,Bang L,Brønsgaard AM

更新日期：1990-05-16 00:00:00

abstract：:Isolated porcine myocardial trabeculae from right atria and left ventricles were paced at 1.5 Hz in tissue baths, and changes in isometric contractile force upon exposure to agonist were studied. Alpha calcitonin gene-related peptide (alpha-CGRP) increased contractile force in nearly half of the trabeculae, whereas th...

journal_title：European journal of pharmacology

authors： Saetrum Opgaard O,de Vries R,Tom B,Edvinsson L,Saxena PR

更新日期：1999-12-03 00:00:00

abstract：:Endoplasmic reticulum (ER) stress and associated protein aggregation are closely associated with human diseases, including alterations in hepatic lipid metabolism. Inhibition of ER stress can have a significant effect on the prevention of hepatic dyslipidemia. Here, we studied the role of 4-phenylbutyric acid (4-PBA),...

journal_title：European journal of pharmacology

authors： Lee HY,Marahatta A,Bhandary B,Kim HR,Chae HJ

更新日期：2016-04-15 00:00:00

abstract：:The areas S of the ventral surface of the brain stem and the immediately surrounding zone were superficially destroyed by the means of electro-coagulation, in 14 cats. This destruction produced a drop in blood pressure, which was transient in 9 and definitive in 4 animals; in one cat only the arterial pressure did not...

journal_title：European journal of pharmacology

authors： Bousquet P,Feldman J,Velly J,Bloch R

更新日期：1975-11-01 00:00:00

abstract：:The effects of hyperosmotic solutions of xylitol were tested on acid and bicarbonate outputs from the rat stomach as well as on acid back-diffusion. Hyperosmotic solutions were instilled into anesthetized rats by an esophageal cannula and drained through a duodenal catheter. Spontaneously secreting and histamine-stimu...

journal_title：European journal of pharmacology

authors： Assouline G,Danon A

更新日期：1984-07-13 00:00:00

abstract：:The effects of caffeine on Ca2+ fluxes and catecholamine secretion in bovine adrenal chromaffin cells were examined. Caffeine inhibited secretion. 45Ca2+ uptake and cytosolic Ca2+ concentration ([Ca2+]i) rise induced by the nicotinic receptor agonist 1.1-dimethyl- 4-phenylpiperazinium (DMPP) and the Na+ channel activa...

journal_title：European journal of pharmacology

authors： Liu PS,Lin YJ,Kao LS

更新日期：1995-11-30 00:00:00

abstract：:Mutant alph1 subunits of the GABA(A) receptor were coexpressed in combination with the wild-type beta2 and gamma2 subunits in human embryonic kidney (HEK) 293 cells. The binding properties of various benzodiazepine site ligands were determined by displacement of ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5...

journal_title：European journal of pharmacology

authors： Schaerer MT,Buhr A,Baur R,Sigel E

更新日期：1998-08-07 00:00:00

abstract：:Patients with somatic mutations of epigenetic regulators are characterized by aberrant chromatin modification patterns. Recent mechanistic studies pairing chemical tool compounds and deep-sequencing technology have greatly broadened our understanding of epigenetic regulation in glioma progression and underpinned alter...

journal_title：European journal of pharmacology

authors： Chen YH,Zeng WJ,Wen ZP,Cheng Q,Chen XP

更新日期：2018-08-15 00:00:00

abstract：:YM992 ((S)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride) is a novel compound that has selective serotonin (5-hydroxytryptamine, 5-HT) re-uptake inhibition and 5-HT2A receptor antagonistic activity in vivo. YM992, fluoxetine and citalopram showed 5-HT uptake inhibition activity in l-5-hydroxy-tryptop...

journal_title：European journal of pharmacology

authors： Takeuchi H,Yatsugi S,Hatanaka K,Nakato K,Hattori H,Sonoda R,Koshiya K,Fujii M,Yamaguchi T

更新日期：1997-06-18 00:00:00

abstract：:Soluble amyloid β-protein (Aβ) oligomers are primary mediators of synaptic dysfunction associated with the progression of Alzheimer's disease. Such Aβ oligomers exist dependent on their rates of aggregation and metabolism. Use of selective somatostatin receptor-subtype agonists have been identified as a potential mean...

journal_title：European journal of pharmacology

authors： Sandoval KE,Farr SA,Banks WA,Crider AM,Morley JE,Witt KA

更新日期：2012-05-15 00:00:00

abstract：:The glutamate receptor agonists, kainate and N-methyl-D-aspartate (NMDA) result in the elevation of intracellular calcium levels ([Ca2+]i) in primary cultures of cerebellar granule neurons. Several tricyclic antidepressants (TCAs), amitriptyline (0.5-1 microM), desipramine (1 microM) and doxepine (1 microM) partially ...

journal_title：European journal of pharmacology

authors： Cai Z,McCaslin PP

更新日期：1992-08-14 00:00:00

abstract：:Endothelial dysfunction is associated with a reduced bioavailability of nitric oxide (NO). In this study, the effects of 17β-estradiol supplement on endothelial function were examined in ovariectomized (OVX) rats following long-term inhibition of NO synthases with L-NAME. Female Sprague Dawley rats were ovariectomized...

journal_title：European journal of pharmacology

authors： Shi Y,Leung SWS

更新日期：2020-09-05 00:00:00

abstract：:The administration of radioactive angiotensin I to the retrogradely perfused feline adrenal gland caused a brisk discharge of catecholamines. Recovery of the labelled decapeptide and metabolites in the adrenal effluent fluid was complete in 5 min. Radioimmunoassay of this perfusate revealed that most of the peptide re...

journal_title：European journal of pharmacology

authors： Ackerly JA,Felger TS,Peach MJ

更新日期：1976-07-01 00:00:00

abstract：:The present work describes the mechanisms involved in the vasorelaxant effect of the diterpene ent-kaur-16-en-19-oic acid (kaurenoic acid). Kaurenoic acid (10, 50 and 100 microM) concentration-dependently inhibited phenylephrine and KCl-induced contraction in either endothelium-intact or -denuded rat aortic rings. Kau...

journal_title：European journal of pharmacology

authors： Tirapelli CR,Ambrosio SR,da Costa FB,Coutinho ST,de Oliveira DC,de Oliveira AM

更新日期：2004-05-25 00:00:00

abstract：:Mitiglinide (KAD-1229), a new anti-diabetic drug, is thought to stimulate insulin secretion by closing the ATP-sensitive K+ (K(ATP)) channels in pancreatic beta-cells. However, its selectivity for the various K(ATP) channels is not known. In this study, we examined the effects of mitiglinide on various cloned K(ATP) c...

journal_title：European journal of pharmacology

authors： Sunaga Y,Gonoi T,Shibasaki T,Ichikawa K,Kusama H,Yano H,Seino S

更新日期：2001-11-09 00:00:00

abstract：:Immunopharmacology is one of the most dynamic areas in pharmacology encompassing classical immunosuppressive drugs which reveal completely new clues concerning their mode of action as well as novel molecular biology approaches for treating inflammatory and autoimmune diseases, infections and cancer. This article focus...

journal_title：European journal of pharmacology

authors： Pfeilschifter J,Mühl H

更新日期：1999-06-30 00:00:00

abstract：:Intravenous injection of ovalbumin into actively and passively sensitized guinea-pig resulted in acute circulatory collapse. The plasma level of immunoreactive endothelin rose from 22 +/- 2 to 40 +/- 7 fmol/ml (n = 12, P < 0.01) and 29 +/- 5 fmol/ml (n = 12, P < 0.01) in actively and passively sensitized animals, resp...

journal_title：European journal of pharmacology

authors： Filep JG,Télémaque S,Battistini B,Sirois P,D'Orléans-Juste P

更新日期：1993-08-03 00:00:00

abstract：:This paper examines the biochemical and behaviour changes induced by an acute stress (five 10-s, 1-mA foot-shocks) in three groups of rats: (1) never stressed, (2) subjected to chronic variate stress for 20 days, (3) subjected to the same chronic stress and treated with 5 mg/kg per day amitriptyline. After 15 min, acu...

journal_title：European journal of pharmacology

authors： Ferretti C,Blengio M,Gamalero SR,Ghi P

更新日期：1995-06-23 00:00:00

abstract：:A close relationship between the renin-angiotensin system and the pathophysiology of diabetic retinopathy has been suggested, several angiotensin II type 1 receptor (angiotensin AT1 receptor) antagonists being effective in animal models. Therefore, we examined the efficacy of an angiotensin AT1 receptor antagonist, ol...

journal_title：European journal of pharmacology

authors： Nakamura H,Inoue T,Arakawa N,Shimizu Y,Yoshigae Y,Fujimori I,Shimakawa E,Toyoshi T,Yokoyama T

更新日期：2005-04-11 00:00:00

abstract：:Morphine-induced analgesia, and the development of morphine-induced tolerance and dependence was determined in mice which had drunk caffeinated water (1 mg/ml) for 14 days or in mice which had received (-)-N6-(phenylisopropyl)-adenosine (PIA) 1 mg/kg i.p. for 14 days. Analgesia was assessed by the tail flick assay. Th...

journal_title：European journal of pharmacology

authors： Ahlijanian MK,Takemori AE

更新日期：1986-01-14 00:00:00