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Nitrate tolerance and aging in isolated rat aorta.

Abstract：

:The purpose of this study was to determine whether there are age-related changes in the extent of in vitro-induced nitrate tolerance. Nitroglycerin pre-exposure (10 microM for 30 min) provoked a significant shift to the right of the dose-response curve to nitroglycerin in aortae isolated from rats of 8 weeks, 12 and 18 months. However, this shift to the right was significantly larger at 18 months, both when KCl or phenylephrine were used as contractile agents. On the contrary, nitroglycerin pre-exposure did not significantly alter the dose-dependent relaxation to Sin-1 (3-morpholinosydnonimine, the active metabolite of molsidomine) at 8 weeks, 12 and 18 months. These data indicate that the extent of the in vitro-induced nitrate tolerance is larger when aortae are isolated from senescent rats. This increase in tolerance does not appear to involve desensitization of guanylate cyclase.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Unger P,Berkenboom G,Brékine D,Fontaine J

doi

10.1016/0926-6917(93)90036-p

subject

Has Abstract

pub_date

1993-08-02 00:00:00

pages

145-9

issue

2

eissn

0014-2999

issn

1879-0712

journal_volume

248

pub_type

杂志文章

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