Failure to detect 6-hydroxydopamine in rat striatum after the dopamine releasing drugs dexamphetamine, methylamphetamine and MPTP.

abstract：:Post-traumatic stress disorder (PTSD) and phobias belong to the most common anxiety disorders and to the most common psychiatric illnesses in general. In both disorders, aversive memories are thought to play an important role in the pathogenesis and symptomatology. Previously, we have reported that elevated glucocorti...

journal_title：European journal of pharmacology

authors： de Quervain DJ,Margraf J

更新日期：2008-04-07 00:00:00

abstract：:The acute administration of MDMA has been shown to promote glycogenolysis and increase the extracellular concentration of glucose in the striatum. In the present study the role of serotonergic and/or noradrenergic mechanisms in the MDMA-induced increase in extracellular glucose and glycogenolysis was assessed. The rel...

journal_title：European journal of pharmacology

authors： Pachmerhiwala R,Bhide N,Straiko M,Gudelsky GA

更新日期：2010-10-10 00:00:00

abstract：:The cyclic peptide urotensin II has recently been cloned from human and reported to potently constrict primate blood vessels. To elucidate the cellular signalling mechanisms of this peptide, we investigated a possible relationship of vasomotor effects of human urotensin II and phosphoinositide turnover in isolated rab...

journal_title：European journal of pharmacology

authors： Saetrum Opgaard O,Nothacker H,Ehlert FJ,Krause DN

更新日期：2000-10-13 00:00:00

abstract：:The effect of progesterone on isolated rabbit coronary arteries and its possible mechanism was investigated by measuring changes of isometric tension. Progesterone (1, 3, 10 and 30 microM) induced significant coronary relaxation in K+ (30 mM)-, prostaglandin F2 alpha (3 microM)- or Bay K 8644 (1 microM plus 15 mM K+)-...

journal_title：European journal of pharmacology

authors： Jiang CW,Sarrel PM,Lindsay DC,Poole-Wilson PA,Collins P

更新日期：1992-02-11 00:00:00

abstract：:The identity of the muscarinic receptor subtype in the chick ileum was investigated in functional and binding studies. Preliminary studies [Choo, L.-K., Mitchelson, F., Napier, P. 1988. J. Auton. Pharmacol. 8, 259-266] suggested apparent avian and mammalian family differences in the muscarinic receptor profile of ilea...

journal_title：European journal of pharmacology

authors： Darroch S,Irving HR,Mitchelson FJ

更新日期：2000-08-18 00:00:00

abstract：:We investigated the effects of KF19514 (5-phenyl-3-(3-pyridyl)methyl-3H-imidazo[4,5-c][1,8]naphthyridin-4 (5H)-one) on bronchoconstriction and allergic inflammation in guinea pigs and on tumor necrosis factor-alpha production in mice. KF19514 inhibited phosphodiesterase 4 (IC50 = 0.40 microM) and phosphodiesterase 1 (...

journal_title：European journal of pharmacology

authors： Manabe H,Akuta K,Sejimo H,Kawasaki H,Nukui E,Ichimura M,Kase H,Kawakita T,Suzuki F,Kitamura S,Sato S,Ohmori K

更新日期：1997-07-30 00:00:00

abstract：:Although a number of studies have shown that perivascular adipose tissue (PVAT) attenuates arterial contraction through the release of perivascular-derived relaxation factors (PVRF), the role of PVAT in modulating venous function and its mechanism(s) remained unknown. Here we examined the role of PVAT in the modulatio...

journal_title：European journal of pharmacology

authors： Lu C,Zhao AX,Gao YJ,Lee RM

更新日期：2011-04-25 00:00:00

abstract：:Our aim in performing this study was to analyze in vivo the cell death mechanism induced by toxic doses of digitalis compounds on guinea-pig cardiomyocytes. We analyzed three study groups of five male guinea pigs each. Guinea pigs were intoxicated under anesthesia with ouabain or digoxin (at a 50-60% lethal dose); the...

journal_title：European journal of pharmacology

authors： Ramirez-Ortega M,Zarco G,Maldonado V,Carrillo JF,Ramos P,Ceballos G,Melendez-Zajgla J,Garcia N,Zazueta C,Chanona J,Suarez J,Pastelin G

更新日期：2007-07-02 00:00:00

abstract：:Antagonists, but not agonists, of the 5-HT3 receptor are useful therapeutic agents, and it is possible that partial agonists may also be potentially useful in the clinic. Here we show that 5-fluorotryptamine (5-FT) is a partial agonist at both 5-HT3A and 5-HT3AB receptors with an Rmax (Imax/Imax 5-HT) of 0.64 and 0.45...

journal_title：European journal of pharmacology

authors： Bower KS,Price KL,Sturdee LE,Dayrell M,Dougherty DA,Lummis SC

更新日期：2008-02-12 00:00:00

abstract：:A high dose of apomorphine, a stimulator of brain dopamine receptors, caused a reduction in total sleep, intermediate sleep and a delayed appearance of paradoxical sleep. With a lower dose, a small and not significant trend toward an increase of paradoxical sleep was observed. Spiroperidol, considered as a specific bl...

journal_title：European journal of pharmacology

authors： Kafi S,Gaillard JM

更新日期：1976-08-01 00:00:00

abstract：:The effect of resveratrol, an aryl hydrocarbon receptor antagonist, on the teratogenicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated. Pregnant C57BL/6J mice were orally administered resveratrol (50 mg/kg) for 6 consecutive days, from gestational day (GD) 8 to GD13, followed by an oral chall...

journal_title：European journal of pharmacology

authors： Jang JY,Park D,Shin S,Jeon JH,Choi BI,Joo SS,Hwang SY,Nahm SS,Kim YB

更新日期：2008-09-04 00:00:00

abstract：:Multiple methamphetamine administrations rapidly decrease rat striatal dopamine transporter activity. To determine the species specificity of this phenomenon, the present studies examined effects of this stimulant on the dopamine transporter in mice. As in rats, multiple methamphetamine injections rapidly reduced stri...

journal_title：European journal of pharmacology

authors： Sandoval V,Hanson GR,Fleckenstein AE

更新日期：2000-12-15 00:00:00

abstract：:Opiates depress the potassium-induced efflux of [3H]noradrenaline from the mouse vas deferens in a concentration-dependent (the IC50 for normorphine was 1.5 microM), stereospecific and naloxone-reversible manner. As the concentration of sodium in the extracellular fluid was reduced, the inhibitory action of opiates wa...

journal_title：European journal of pharmacology

authors： Sim JA,Henderson G

更新日期：1981-04-09 00:00:00

abstract：:The effects of delta9-THC and its ethanol vehicle on pilocarpine-induced parotid gland secretions were investigated in rats. Single doses of delta9-THC (1, 2.5, 5 and 10 mg/kg) or 95% ethanol were administered i.v. prior to pilocarpine stimulation of saliva. Total flow, alpha-amylase and cation content of the induced ...

journal_title：European journal of pharmacology

authors： Nagle B,Tomassone BM,Digregorio J,Piraino A

更新日期：1976-12-01 00:00:00

abstract：:Synaptic transmission in intact pieces of the Torpedo electric organ treated with vesamicol (2-(4-phenylpiperidino)cyclohexanol, formerly AH5183) was elicited by trains of repetitive electrical stimulation at different frequencies. When the frequency of stimulation was increased from 10 to 50 or 100 Hz, micromolar con...

journal_title：European journal of pharmacology

authors： Girod R,Loctin F,Dunant Y

更新日期：1991-03-19 00:00:00

abstract：:Renal adrenergic interactions of intravenously and intrarenal arterially administered angiotensin II were studied in the anesthetized rabbit. Systemic arterial blood pressure and left renal blood flow were monitored. Bolus doses of angiotensin II, 50 and 100 ng/kg given intravenously, caused an immediate reduction in ...

journal_title：European journal of pharmacology

authors： Chen K,Zimmerman BG

更新日期：1995-09-25 00:00:00

abstract：:Diabetic nephropathy (DN) is a major cause of end-stage renal disease and one of the most severe diabetic complications. However, there is lack of effective treatments for DN and the underlying mechanisms of the renal injury remain unclear. In current study, we evaluated the effects of silibinin on DN and further expl...

journal_title：European journal of pharmacology

authors： Liu Y,Ye J,Cao Y,Zhang R,Wang Y,Zhang S,Dai W,Ye S

更新日期：2019-02-15 00:00:00

abstract：:Spontaneous electrical and mechanical activity was observed when single myocytes from guinea-pig hearts were loaded with sodium by direct intracellular application. Transient membrane depolarizations were found to be due to spontaneous inward currents (Isp). Both Isp and spontaneous contractions were abolished by 2',3...

journal_title：European journal of pharmacology

authors： Cragoe E,Ravens U,Wettwer E

更新日期：1987-08-04 00:00:00

abstract：:FR 172357, a new non-peptide antagonist of the kinin B(2) receptor was tested in three isolated vessels, the human umbilical vein, the rabbit jugular vein, and the pig coronary artery, to evaluate its antagonistic activities against bradykinin. FR 172357 displaced to the right the concentration-response curves of brad...

journal_title：European journal of pharmacology

authors： Rizzi C,Rizzi A,Calò G,Jorizzo G,Agnello G,Mollica G,Inamura N,Regoli D

更新日期：1999-12-10 00:00:00

abstract：:Five different muscarinic receptor subtypes can be distinguished by the differences in their amino acid sequence, the coupled signal transduction system, pharmacological binding properties and activation of ionic fluxes. The present study served to characterize the binding profile of muscarinic receptors in human colo...

journal_title：European journal of pharmacology

authors： Kopp R,Lambrecht G,Mutschler E,Moser U,Tacke R,Pfeiffer A

更新日期：1989-10-17 00:00:00

abstract：:We assessed the effects of active site-directed, fibrinogen recognition exosite (FRE)-directed and bifunctional thrombin inhibitors, on shear-induced platelet reactivity (adhesion/aggregation) and dynamic coagulation (coagulation of flowing blood). An in vitro test for shear-induced haemostatic plug formation and dyna...

journal_title：European journal of pharmacology

authors： Taka T,Konishi Y,Slon-Usakiewicz J,Medvedkin V,Tsuda Y,Okada Y,Seki J,Yamamoto J

更新日期：2000-10-13 00:00:00

abstract：:Field stimulation of isolated rat vas deferens preparations caused a twitch contraction followed by a slower phasic contraction. Exogenously applied ATP and noradrenaline caused rapid contractions and slowly developing contractions respectively. Pretreatment with phentolamine antagonised the phasic response to stimula...

journal_title：European journal of pharmacology

authors： Satchell D

更新日期：1986-12-16 00:00:00

abstract：:The therapeutic efficacy of antidepressant drugs that inhibit the reuptake of serotonin (5-hydroxytryptamine, 5-HT) may be enhanced by blocking their indirect activation of 5-HT(1A) autoreceptors, which mediate feedback inhibition of serotonergic neuronal activity. In this study, we examined the effects of venlafaxine...

journal_title：European journal of pharmacology

authors： Bjorvatn B,Fornal CA,Martín FJ,Metzler CW,Jacobs BL

更新日期：2000-09-15 00:00:00

abstract：:Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. Th...

journal_title：European journal of pharmacology

authors： McNamee K,Williams R,Seed M

更新日期：2015-07-15 00:00:00

abstract：:We discovered a novel compound, YM-126414 [1,3, 3-trimethyl-2-(2-phenylaminovinyl)-3H-indolium perchlorate], which stimulates glucose uptake in skeletal muscle cells in vitro. This compound increased the rate of consumption of glucose by C2C12 mouse myoblast cells in a dose-dependent manner (EC(50)=10 nM). To investig...

journal_title：European journal of pharmacology

authors： Shimokawa T,Kagami M,Kato M,Kurosaki E,Shibasaki M,Katoh M

更新日期：2000-12-20 00:00:00

abstract：:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exc...

journal_title：European journal of pharmacology

authors： Kuribayashi Y,Itoh N,Kitano M,Ohashi N

更新日期：1999-10-27 00:00:00

abstract：:The administration of ethyl beta-carboline-3-carboxylate (beta-CCE), a ligand for benzodiazepine receptors, did not affect the cerebellar cyclic GMP level in mice, but giving beta-CCE together with diazepam significantly inhibited the diazepam-induced decrease in cyclic GMP. The fact that no antagonism was observed wh...

journal_title：European journal of pharmacology

authors： Fujimoto M,Kawasaki K,Matsushita A,Okabayashi T

更新日期：1982-05-21 00:00:00

abstract：:In the mouse tail-flick test, neither the racemate of N-allylnormetazocine (NANM) nor its optical isomers showed antinociceptive activity. However, all three antagonized morphine's tail-flick effects. In the phenylquinone test in mice, the racemate and (-)-isomer of NANM showed agonist activity and antagonized morphin...

journal_title：European journal of pharmacology

authors： Aceto MD,May EL

更新日期：1983-07-22 00:00:00

abstract：:The goal of this report is to present the results obtained with three new GABAB receptor antagonists. CGP 54062 has an IC50 in a GABAB binding test of 0.013 microM which is roughly 2500-fold lower than one of the most potent blockers known so far, CGP 35348 (IC50 = 34 microM). CGP 46381 and CGP 36742 have IC50s of 4.9...

journal_title：European journal of pharmacology

authors： Olpe HR,Steinmann MW,Ferrat T,Pozza MF,Greiner K,Brugger F,Froestl W,Mickel SJ,Bittiger H

更新日期：1993-03-23 00:00:00

abstract：:The interaction of the delta-opiate agonist [D-Ala2,D]Leu5]enkephalin (DADL) with the mu-opiate ligands dihydromorphine (DHM) and naloxone and the kappa-opiate ligand ethylketocyclazocine (EK) was studied in rat diencephalic membranes which contain mainly mu-opiate binding sites. Saturation binding experiments perform...

journal_title：European journal of pharmacology

authors： Pfeiffer A,Herz A

更新日期：1982-02-05 00:00:00