当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > The effect of extracellular sodium ion concentration on the action of opiates to inhibit potassium-evoked release of [3H]noradrenaline from the mouse vas deferens.

The effect of extracellular sodium ion concentration on the action of opiates to inhibit potassium-evoked release of [3H]noradrenaline from the mouse vas deferens.

Abstract：

:Opiates depress the potassium-induced efflux of [3H]noradrenaline from the mouse vas deferens in a concentration-dependent (the IC50 for normorphine was 1.5 microM), stereospecific and naloxone-reversible manner. As the concentration of sodium in the extracellular fluid was reduced, the inhibitory action of opiates was also reduced. This attenuation of opiate action is the converse of that predicted by the 'sodium-shift' observed in opiate binding studies in which lowering the sodium concentration potentiates opiate agonist binding. The relevance of sodium to the pharmacological actions of opiates is discussed.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Sim JA,Henderson G

doi

10.1016/0014-2999(81)90354-x

subject

Has Abstract

pub_date

1981-04-09 00:00:00

pages

437-43

issue

4

eissn

0014-2999

issn

1879-0712

pii

0014-2999(81)90354-X

journal_volume

70

pub_type

杂志文章

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