Abstract：
:Disodium cromoglycate is an anti-asthmatic drug that has mast cell-stabilizing effects and other anti-inflammatory effects. However, the mechanisms of its anti-inflammatory effects are unclear. In this study, we evaluated effects of disodium cromoglycate on eosinophilia, early and late asthmatic responses, and production of arachidonic acid metabolites in guinea pig lungs. Guinea pigs were alternately sensitized and challenged by exposure to mists of ovalbumin+Al(OH)(3) and ovalbumin, respectively. Disodium cromoglycate (0.5-2 mg/0.1 ml/animal) administered intratracheally before the fifth challenge dose-dependently inhibited asthmatic response, but early asthmatic response was not affected. Disodium cromoglycate at 2 mg/animal potently suppressed increases in cysteinyl leukotrienes (CysLTs) and thromboxane A(2) in the lung during late asthmatic response. Eosinophilia was slightly reduced by disodium cromoglycate. The inhibitory effect of disodium cromoglycate on late asthmatic response is apparently due to inhibition of the release of arachidonic acid metabolites, some of which may be derived from eosinophils that infiltrate the lung.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Nabe T,Yamamoto M,Suga M,Kohno Sdoi
10.1016/j.ejphar.2004.06.033keywords:
subject
Has Abstractpub_date
2004-08-16 00:00:00pages
97-104issue
1eissn
0014-2999issn
1879-0712pii
S0014-2999(04)00656-9journal_volume
497pub_type
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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