Anti-arrhythmic action of nadolol, a beta-adrenergic receptor blocking agent.

abstract：:The influence of (+/-)-tamsulosin, a selective alpha 1A-adrenoceptor antagonist, on the positive inotropic effect and the accumulation of inositol phosphates that are induced via alpha 1-adrenoceptors was studied in comparison with that of another alpha 1A-adrenoceptor ligand oxymetazoline in the rabbit ventricular my...

journal_title：European journal of pharmacology

authors： Yang HT,Endoh M

更新日期：1996-10-03 00:00:00

abstract：:Large doses of dexamphetamine, methylamphetamine and MPTP failed to induce the formation of 6-hydroxydopamine (6-OHDA) in rat striatum. The potent dopamine (DA) releasing actions of these drugs and of the MPTP metabolite MPP+ were shown by intracerebral dialysis of DA in conscious rats but 6-OHDA was not detectable in...

journal_title：European journal of pharmacology

authors： Rollema H,De Vries JB,Westerink BH,Van Putten FM,Horn AS

更新日期：1986-12-02 00:00:00

abstract：:Inflammatory processes are critical promoting factors of chronic pain states, mostly by inducing peripheral and central sensitization of the nociceptive system. These processes are associated with a massive increase in glutamatergic transmission, sometimes facilitated by spinal disinhibition. In this study, we used et...

journal_title：European journal of pharmacology

authors： Gazzo G,Girard P,Kamoun N,Verleye M,Poisbeau P

更新日期：2019-01-15 00:00:00

abstract：:The localization of neuroleptic receptors was studied in the caudate-putamen (CP) and the zona compacta of the substantia nigra using light microscopic autoradiography of 3H-spiperone binding sites. Lesion of the dopaminergic input to the caudate-putamen produced an increase in receptors in the CP, possibly reflecting...

journal_title：European journal of pharmacology

authors： Murrin LC,Gale K,Kuhar MJ

更新日期：1979-12-07 00:00:00

abstract：:The effects of a serotonin (5-HT) releasing drug, p-chloroamphetamine, on plasma glucose levels were investigated in rats. p-Chloroamphetamine elicited a significant hyperglycemia. The hyperglycemic effects of p-chloroamphetamine were completely prevented by the 5-HT synthesis inhibitor, p-chlorophenylalanine. Prior a...

journal_title：European journal of pharmacology

authors： Yamada J,Sugimoto Y,Yoshikawa T

更新日期：1998-10-23 00:00:00

abstract：:Previously, sex differences have been observed in the behavioral effects of acute and chronic cocaine administration. In the present experiment, male and female rats were trained to discriminate intraperitoneal injections of 10.0 mg/kg cocaine from its vehicle. It was hypothesized that the subjective effects of cocain...

journal_title：European journal of pharmacology

authors： Anderson KG,van Haaren F

更新日期：1999-10-08 00:00:00

abstract：:The activity of the four glycoterpenoids: two saponins, verbascosaponin A and verbascosaponin, and two iridoids, scropolioside A and scrovalentinoside, isolated from Scrophularia auriculata ssp. pseudoauriculata, were studied in different models of acute and chronic inflammation. Both saponins significantly inhibited ...

journal_title：European journal of pharmacology

authors： Giner RM,Villalba ML,Recio MC,Máñez S,Cerdá-Nicolás M,Ríos J

更新日期：2000-02-18 00:00:00

abstract：:When injected directly into the tail, U50,488H is a potent analgesic in the tailflick assay (ED50 3.1 micrograms). The analgesic activity is lost if the radiant heat is focused 1 cm away from the site of injection. The kappa 1-opioid receptor antagonist nor-binaltorphimine given systemically reverses the local analges...

journal_title：European journal of pharmacology

authors： Kolesnikov Y,Jain S,Wilson R,Pasternak GW

更新日期：1996-08-29 00:00:00

abstract：:Galloyl group-containing catechins, such as epigallocatechin-3 gallate, inhibit receptor tyrosine kinase activity of several growth factor receptors. This study investigated the effects of epigallocatechin-3 gallate, as compared to epicatechin, on vascular endothelial growth factor-induced intracellular signaling and ...

journal_title：European journal of pharmacology

authors： Neuhaus T,Pabst S,Stier S,Weber AA,Schrör K,Sachinidis A,Vetter H,Ko YD

更新日期：2004-01-12 00:00:00

abstract：:The tripeptides SD-34 and SD-25 induced atropine-, guanethidine-, antihistaminics-resistant but naloxone-sensitive contractions of isolated rat distal colon. They appeared to act on an opioid receptor, probably of the mu subtype, distinct from those for methionine enkephalin and morphine, because the pA2 values of nal...

journal_title：European journal of pharmacology

authors： Moritoki H,Takei M,Kotani M,Kiso Y,Ishida Y,Endoh K

更新日期：1984-04-13 00:00:00

abstract：:Lung fibrosis is a common side effect of the chemotherapeutic agent, bleomycin. Current evidence suggests that reactive oxygen species may play a key role in the development of lung fibrosis. The present study examined the effect of mesna on bleomycin-induced lung fibrosis in rats. Animals were divided into three grou...

journal_title：European journal of pharmacology

authors： El-Medany A,Hagar HH,Moursi M,At Muhammed R,El-Rakhawy FI,El-Medany G

更新日期：2005-02-10 00:00:00

abstract：:The present study examines the effect of three adenosine receptor antagonists on tremulous jaw movements (TJMs), an animal model of tremor. Forty-five rats were pre-treated with one adenosine antagonist: caffeine (0.0, 5.0, or 10.0 mg/kg; non-selective adenosine receptor antagonist), 8-cyclopentyltheophylline (CPT; 0....

journal_title：European journal of pharmacology

authors： Johnson JA,Montgomery AP,Starr ER,Ludwig J,Trevitt J

更新日期：2018-08-15 00:00:00

abstract：:Baicalein, a naturally occurring flavone, has been proved as a promising chemopreventive compound for many chronic human diseases. The aim of this work was to investigate whether treatment with baicalein prevented nonalcoholic steatohepatitis (NASH) induced by methionine-choline-deficient (MCD) diet. Rats were divided...

journal_title：European journal of pharmacology

authors： Xin HG,Zhang BB,Wu ZQ,Hang XF,Xu WS,Ni W,Zhang RQ,Miao XH

更新日期：2014-09-05 00:00:00

abstract：:Obese mice display overactive bladder (OAB) associated with impaired urethra smooth muscle (USM) function. In this study, we evaluated the role of the adipose tissue surrounding the urethra and prostate in obese mice (here referred as periprostatic adipose tissue; PPAT) to the USM dysfunction. Male C57BL6/JUnib mice f...

journal_title：European journal of pharmacology

authors： Alexandre EC,Calmasini FB,Sponton ACDS,de Oliveira MG,André DM,Silva FH,Delbin MA,Mónica FZ,Antunes E

更新日期：2018-10-05 00:00:00

abstract：:Acute dystonic reactions are motor side effects that occur soon after the initiation of neuroleptic treatment. Although earlier studies indicate that these abnormal movements can be induced in animals and humans via activation of sigma receptors, the relative contribution of the different sigma receptor subtypes is un...

journal_title：European journal of pharmacology

authors： Matsumoto RR,Pouw B

更新日期：2000-08-04 00:00:00

abstract：:Effects of N-ethylmaleimide or forskolin on electrically evoked dopamine release were investigated in striatal slices of rats pretreated with methamphetamine. N-Ethylmaleimide and forskolin both enhanced the evoked dopamine release in a concentration-dependent manner. The enhancement by N-ethylmaleimide of spontaneous...

journal_title：European journal of pharmacology

authors： Yamada S,Yokoo H,Nishi S

更新日期：1994-05-23 00:00:00

abstract：:Two major effector systems are frequently implicated in the immune and endothelial cell alternations associated with inflammation. They include the enhanced production of reactive oxygen species and diminished bioavailability of nitric oxide (NO). Importantly, these processes can be regulated by endogenously produced ...

journal_title：European journal of pharmacology

authors： Pekarova M,Kubala L,Martiskova H,Bino L,Twarogova M,Klinke A,Rudolph TK,Kuchtova Z,Kolarova H,Ambrozova G,Kuchta R,Kadlec J,Lojek A

更新日期：2013-08-05 00:00:00

abstract：:Multiple myeloma is an incurable hematological malignancy. Different studies demonstrated the occurrence of genetic and epigenetic alterations in multiple myeloma. Histone lysine methylation has emerged as a central epigenetic change in the organization of eukaryotic chromatin with far-reaching implications for the re...

journal_title：European journal of pharmacology

authors： Zhao F,Chen Y,Zeng L,Li R,Zeng R,Wen L,Liu Y,Zhang C

更新日期：2010-11-10 00:00:00

abstract：:In conscious rats, intracerebroventricular (i.c.v.) treatment with the GABA agonist muscimol (1-100 ng) suppressed the pressor responses to ANG II (100 ng i.c.v.) in a dose-dependent and reversible fashion. Treatment i.c.v. with GABA (1-500 micrograms) produced a similar but shorter inhibition. Inhibition of endogenou...

journal_title：European journal of pharmacology

authors： Unger T,Bles F,Ganten D,Lang RE,Rettig R,Schwab NA

更新日期：1983-05-20 00:00:00

abstract：:Because both long-term adrenoceptor agonist administration and antidepressant treatment in animals down-regulate CNS beta-adrenoceptors and attenuate brain adenylate cyclase activity, beta-adrenoceptor agonists may also possess antidepressant properties. We compared the effects of the centrally acting beta-adrenocepto...

journal_title：European journal of pharmacology

authors： Finnegan KT,Terwilliger MM,Berger PA,Hollister LE,Csernansky JG

更新日期：1987-02-10 00:00:00

abstract：:The failure of alpha 1-adrenoceptor antagonists, prazosin and indoramin, to cause a reflex tachycardia was investigated in the anaesthetised cat. Recordings were made of preganglionic sympathetic nerve activity from the third or fourth white ramus communicans, femoral arterial conductance, heart rate and blood pressur...

journal_title：European journal of pharmacology

authors： Ramage AG

更新日期：1984-11-27 00:00:00

abstract：:Stimulation of [35S]GTPgammaS binding by serotonin (5-hydroxytryptamine, 5-HT) receptor ligands was characterized in rat hippocampal membranes. The optimized assay contained 30-50 microg protein, 300 microM GDP and 0.1 nM [35S]GTPgammaS, incubated at 37 degrees C for 20 min. At 10 microM, the 5-HT1A receptor agonist R...

journal_title：European journal of pharmacology

authors： Alper RH,Nelson DL

更新日期：1998-02-19 00:00:00

abstract：:SB203580 is the prototypical p38 MAPK inhibitor; however it cannot be used clinically due to liver toxicity. We developed a structural analogue of SB203580 - ML3403 - with equal in vitro and ex vivo p38alpha MAPK inhibition as SB203580, but with reduced activity towards liver cytochrome P450 enzymes. In addition, we d...

journal_title：European journal of pharmacology

authors： Munoz L,Ramsay EE,Manetsch M,Ge Q,Peifer C,Laufer S,Ammit AJ

更新日期：2010-06-10 00:00:00

abstract：:Dorsal root potentials were recorded from urethane-anaesthetised rats. Bicuculline, a recognised GABA antagonist, reduced the amplitude of the potential to 67% of control. Cismethrin, a synthetic pyrethroid insecticide, enhanced the potential to 142% of control values. The convulsions associated with cismethrin poison...

journal_title：European journal of pharmacology

authors： Smith PR

更新日期：1980-08-22 00:00:00

abstract：:The purposes of the present study were to clarify whether some Cl(-) channels exist in rat pleural mesothelial cells, and to investigate functional and molecular characteristics of these channels. Electrophysiological recordings were performed at room temperature using the whole-cell configuration of the patch-clamp t...

journal_title：European journal of pharmacology

authors： Yoshise Y,Ito K,Tsubone H,Kuwahara M

更新日期：2009-07-01 00:00:00

abstract：:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exc...

journal_title：European journal of pharmacology

authors： Kuribayashi Y,Itoh N,Kitano M,Ohashi N

更新日期：1999-10-27 00:00:00

abstract：:Cell-cell interaction through binding of intercellular adhesion molecule (ICAM), B7.1, B7.2 and CD40 on monocytes to their ligands on T-cells plays a number of roles in cytokine . High mobility group box 1 (HMGB1), an abundant and conserved nuclproduction and lymphocyte proliferationear protein, acts in the extracellu...

journal_title：European journal of pharmacology

authors： Kohka Takahashi H,Sadamori H,Liu K,Wake H,Mori S,Yoshino T,Yamamoto Y,Yamamoto H,Nishibori M

更新日期：2013-02-15 00:00:00

abstract：:Endogenous D-serine is known to modulate glutamatergic transmission via interaction with the glycine site of N-methyl-D-aspartate (NMDA) receptors. D-serine is synthesized by racemization of L-serine using an enzymatic reaction catalyzed by serine racemase. Although much attention has been focused on the role of D-ser...

journal_title：European journal of pharmacology

authors： Ghasemi-Kasman M,Dehpour AR,Mani AR

更新日期：2012-12-05 00:00:00

abstract：:Nicotine acts as an agonist of nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors play a role in the modulation of neurotransmitter release in both the central and the peripheral nervous system. Moderate reactive oxygen species levels modulate the regulation of physiological functions e.g. neurotrans...

journal_title：European journal of pharmacology

authors： Ozger Ilhan S,Sarioglu Y,Vural IM,Dileköz E,Oztürk GS,Ercan ZS

更新日期：2008-06-10 00:00:00

abstract：:The effects of three vinca derivatives on [3H]batrachotoxin binding in rat cortical synaptosomes, on the inhibition of whole-cell Na+ currents evoked in voltage-clamped cortical neurones of the rat, on the protection against veratridine-induced cell death in cortical cultures and on the maximal electroshock-induced se...

journal_title：European journal of pharmacology

authors： Erdo SA,Molnár P,Lakics V,Bence JZ,Tömösközi Z

更新日期：1996-10-24 00:00:00