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Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs.

Abstract：

:We evaluated roles of kinins in allergen-induced nasal blockage and sneezing, and development of nasal hyperresponsiveness to leukotriene D4 in a Japanese cedar pollen-induced allergic rhinitis model of guinea pigs. Sensitised guinea pigs were repeatedly challenged by pollen inhalation once every week. Neither a bradykinin B1 receptor antagonist, des-Arg9-[Leu8]bradykinin nor a bradykinin B2 receptor antagonist, icatibant suppressed allergen-induced sneezing and nasal blockage. However, development of nasal hyperresponsiveness to leukotriene D4 was significantly suppressed by them. The amount of bradykinin in nasal cavity lavage fluid was immediately increased after the challenge. In non-sensitised animals, hyperresponsiveness to leukotriene D4 was developed by a bradykinin B2 receptor agonist, bradykinin, but not by a bradykinin B1 receptor agonist, des-Arg10-kallidin, while in the sensitised-challenged animal, both agonists developed hyperresponsiveness. In conclusion, the nasal hyperresponsiveness appeared to be induced by kinins produced in response to the antigen challenge through activation of not only bradykinin B2 but also B1 receptors.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Sugahara S,Nabe T,Mizutani N,Takenaka H,Kohno S

doi

10.1016/s0014-2999(03)02185-x

keywords:

subject

Has Abstract

pub_date

2003-08-29 00:00:00

pages

229-37

issue

3

eissn

0014-2999

issn

1879-0712

pii

S001429990302185X

journal_volume

476

pub_type

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