The effect of calcium channel modulators on blood pressure and pressor responses to noradrenaline in the guinea-pig.

abstract：:Guanosine 3',5'-cyclic monophosphate (cGMP) is an important second messenger in many biological systems including vascular smooth muscle where it mediates relaxation. Cellular levels of cGMP are regulated primarily by three enzymes; nitric oxide (NO) synthase, soluble guanylate cyclase, and cGMP-phosphodiesterase. Bas...

journal_title：European journal of pharmacology

authors： Bina S,Hart JL,Sei Y,Muldoon SM

更新日期：1998-06-19 00:00:00

abstract：:Nitric oxide (10 ppm) inhaled by pigs before or during endotoxin shock induced by an infusion of E. coli lipopolysaccharide. Nitric oxide inhalation selectively attenuated pulmonary hypertension during endotoxin infusion without influencing mean arterial blood pressure and cardiac output. Upon cessation of nitric oxid...

journal_title：European journal of pharmacology

authors： Weitzberg E,Rudehill A,Lundberg JM

更新日期：1993-03-16 00:00:00

abstract：:We used in vitro autoradiography to identify the endothelin-1 receptor subtype(s) in the superficial gray layer of the superior colliculus of rats. These studies showed dense binding of (3-[125I]iodotyrosyl13)-[Ala11,15]Ac-endothelin-1-(6-2 1) (BQ3020) (for endothelin ETB receptors), while tissues incubated with [125I...

journal_title：European journal of pharmacology

authors： D'Amico M,Di Filippo C,Rossi F

更新日期：1998-04-17 00:00:00

abstract：:The effect of omega-conotoxin on opiate analgesia and withdrawal syndrome was investigated in rats. omega-Conotoxin given i.c.v. and i.p. caused weak analgesia in the tail-flick test. When the toxin (20 ng/rat) was given i.c.v. immediately before morphine (1.5 micrograms/rat i.c.v.) the resultant analgesic effect was ...

journal_title：European journal of pharmacology

authors： Basilico L,Parolaro D,Rubino T,Gori E,Giagnoni G

更新日期：1992-07-21 00:00:00

abstract：:Pulmonary and systemic hemodynamic effects of delta 9-tetrahydrocannabinol (delta 9-THC) in conscious dogs and in those anesthetized with morphine (3 mg/kg, i.m.) plus alpha-chloralose (100 mg/kg i.v.) were evaluated in this study. A decrease in the heart rate, cardiac output (PBF) and a concomitant increase in the pu...

journal_title：European journal of pharmacology

authors： Jandhyala BS,Hamed AT

更新日期：1978-12-15 00:00:00

abstract：:Oleuropein (OLE) was found to have anti-inflammatory and anti-oxidant effects. The latest study has shown that it can resist myocardial injury that follows an acute myocardial infarction and can rescue impaired spinal nerve cells. In this study, we investigated the neuroprotective effects of OLE on cerebral ischemia a...

journal_title：European journal of pharmacology

authors： Yu H,Liu P,Tang H,Jing J,Lv X,Chen L,Jiang L,Xu J,Li J

更新日期：2016-03-15 00:00:00

abstract：:We used two experimental models to prove that resveratrol (trans-3,4',5-trihydroxystilbene) reduces cardiac ischemic-reperfusion injury by means of a nitric oxide- and adenosine-dependent mechanism. (1). ACUTE EX VIVO: resveratrol (10 microM, 10 min) infusion in Langendorff-perfused normoxic rat hearts significantly i...

journal_title：European journal of pharmacology

authors： Bradamante S,Barenghi L,Piccinini F,Bertelli AA,De Jonge R,Beemster P,De Jong JW

更新日期：2003-03-28 00:00:00

abstract：:Antiepileptic and antidepressant drugs are the primary treatments for pain relief in diabetic neuropathy. Combination therapy is a valid approach in pain treatment, where a reduction of doses could reduce side effects and still achieve optimal analgesia. We examined the effects of two-drug combinations of gabapentin, ...

journal_title：European journal of pharmacology

authors： Tomić MA,Vucković SM,Stepanović-Petrović RM,Micov AM,Ugresić ND,Prostran MS,Bosković B

更新日期：2010-02-25 00:00:00

abstract：:Prolactin blood level and apomorphine-induced yawning were studied in rats treated with the substituted benzamide amisulpride in association with bromocriptine or carmoxirole; two dopamine D(2) receptor agonists with high or low propensity to cross the brain-blood barrier, respectively. Administration of amisulpride p...

journal_title：European journal of pharmacology

authors： Marchese G,Ruiu S,Casti P,Bartholini F,Saba P,Gessa GL,Pani L

更新日期：2002-06-28 00:00:00

abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) destroys dopamine-containing nigrostriatal neurons and increases the apparent Bmax of both D1 and D2 binding sites in the striatum. However, the changes of Bmax occur at different intervals after the lesion. Up-regulation of D2 sites becomes evident about 3 weeks aft...

journal_title：European journal of pharmacology

authors： Weihmuller FB,Bruno JP,Neff NH,Hadjiconstantinou M

更新日期：1990-05-16 00:00:00

abstract：:The TxA2 receptor antagonist properties of SQ 27,427 [a cyclohexylcarbinol-7-oxabicyclo(2.2.1)heptenoic acid analog] were studied in vitro both in the human platelet and various isolated smooth muscle preparations. SQ 27,427 was found to be a potent inhibitor of human platelet aggregation induced by arachidonic acid, ...

journal_title：European journal of pharmacology

authors： Harris DN,Greenberg R,Phillips MB,Michel IM,Goldenberg HJ,Haslanger MF,Steinbacher TE

更新日期：1984-08-03 00:00:00

abstract：:The effects of RX 781094, a new and potent alpha 2-adrenoceptor antagonist, on locus coeruleus (LC) unit activity were examined. Low doses of RX 781094 produced suppression of spontaneous LC unit activity which could be reversed with yohimbine. The increase in LC firing produced by WB 4101 could also be reversed with ...

journal_title：European journal of pharmacology

authors： Goldstein JM,Knobloch LC,Malick JB

更新日期：1983-07-15 00:00:00

abstract：:We investigated whether tolerance develops to the vasorelaxant effects of a new vasodilator, (+-)-(E)-4-ethyl-2-[(E)-hydroxy-imino]-5-nitro-3-hexenamide (FK409), in isolated canine coronary artery strips and to its hypotensive effect in rats, and whether FK409 activates soluble guanylate cyclase isolated from vascular...

journal_title：European journal of pharmacology

authors： Isono T,Sato N,Yamamoto T,Sawada T,Yamazaki S,Miura S,Furuichi A,Ozaki R,Koibuchi Y,Ohtsuka M

更新日期：1994-08-01 00:00:00

abstract：:Endothelial differentiation gene (EDG) receptors are a new family of eight G protein-coupled receptors for the lysophospholipids lysophosphatitic acid and sphingosine-1-phosphate. In the present experiments, the expression of EDG receptors in rat and human alveolar macrophages was studied by reverse transcription-poly...

journal_title：European journal of pharmacology

authors： Hornuss C,Hammermann R,Fuhrmann M,Juergens UR,Racké K

更新日期：2001-10-19 00:00:00

abstract：:The occurrence and characteristics of binding sites specific for gamma-aminobutyric acid (GABA) and muscimol in the rat stomach were examined by biochemical and autoradiographic techniques, and the effects of GABAergic model compounds on gastric ulceration induced by chemical irritation was studied in intact and unila...

journal_title：European journal of pharmacology

authors： Erdö SL,Ezer E,Matuz J,Wolff JR,Amenta F

更新日期：1989-06-08 00:00:00

abstract：:We have investigated the effects of substituting extracellular Na+ by choline or K+ on responses of quin2- and fura-2-loaded human platelets to thrombin and platelet-activating factor (PAF). Na+ substitution by choline did not affect the extent of the rise in [Ca2+]i evoked by either agonist. The response to thrombin,...

journal_title：European journal of pharmacology

authors： Sage SO,Rink TJ

更新日期：1986-08-22 00:00:00

abstract：:The presence of P2X purinoceptors in human umbilical vessels were studied with organ bath recording, radioligand binding assays, autoradiography, and immunohistochemistry. In isolated umbilical arteries and veins from normal term pregnancy, both ATP and alpha,beta-methylene ATP caused concentration-dependent contracti...

journal_title：European journal of pharmacology

authors： Bo X,Sexton A,Xiang Z,Nori SL,Burnstock G

更新日期：1998-07-17 00:00:00

abstract：:We have reported that neutrophil infiltration into gastric mucosa is closely related to gastric mucosal lesion development in rats with water immersion restraint stress. In this study, we examined the effect of teprenone, which is known to prevent gastric mucosal injury through stimulation of gastric mucus synthesis a...

journal_title：European journal of pharmacology

authors： Nishida K,Ohta Y,Ishiguro I

更新日期：1998-07-31 00:00:00

abstract：:Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1H-pyrazole ca...

journal_title：European journal of pharmacology

authors： Aceto MD,Scates SM,Lowe JA,Martin BR

更新日期：1995-08-25 00:00:00

abstract：:An intricate surveillance network consisting of enteroendocrine cells, immune cells and sensory nerve fibres monitors the luminal and interstitial environment in the alimentary canal. Functional bowel disorders are characterized by persistent alterations in digestive regulation and gastrointestinal discomfort and pain...

journal_title：European journal of pharmacology

authors： Holzer P

更新日期：2001-10-19 00:00:00

abstract：:Inhibition of glutamate carboxypeptidase (GCP) II (EC 3.4.17.21), also termed N-acetylated alpha-linked acidic dipeptidase (NAALADase), has been shown to protect against ischemic injury presumably via decreasing glutamate and increasing N-acetyl-aspartyl-glutamate (NAAG). NAAG is a potent and selective mGlu3 receptor ...

journal_title：European journal of pharmacology

authors： Thomas AG,Liu W,Olkowski JL,Tang Z,Lin Q,Lu XC,Slusher BS

更新日期：2001-10-26 00:00:00

abstract：:Genetic factors significantly contribute to the determination of human personality traits assessed by self-report questionnaires. However, only in the past few years have common genetic polymorphisms especially the dopamine D4 receptor and the serotonin transporter promoter region been associated with specific persona...

journal_title：European journal of pharmacology

authors： Ebstein RP,Benjamin J,Belmaker RH

更新日期：2000-12-27 00:00:00

abstract：:Tobramycin inhalation therapy is an effective therapy for cystic fibrosis as well as severe bronchiectasis that is colonized with Pseudomonas aeruginosa. The mechanism responsible for the efficacy of tobramycin in the treatment of severe chronic infectious diseases has not been elucidated. We demonstrate that high-dos...

journal_title：European journal of pharmacology

authors： Nakamura S,Yanagihara K,Araki N,Yamada K,Morinaga Y,Izumikawa K,Seki M,Kakeya H,Yamamoto Y,Kamihira S,Kohno S

更新日期：2011-05-20 00:00:00

abstract：:The correlation between the Phosphoinositide 3-kinase (PI3K) axis and crucial mechanisms involved in the maintenance of the neoplastic nature of multiple myeloma (MM) has recently evolved a general agreement that PI3K inhibition-based therapies could construct an exciting perspective for the future treatment strategie...

journal_title：European journal of pharmacology

authors： Safaroghli-Azar A,Bashash D,Kazemi A,Pourbagheri-Sigaroodi A,Momeny M

更新日期：2019-01-05 00:00:00

abstract：:WIN 64338 (phosphonium, [[4-[[2-[[bis(cyclohexylamino) methylene] amino]-3-(2-naphthalenyl) 1-oxopropyl]amino]-phenyl]- tributyl, chloride, monohydrochloride) is the first potent nonpeptide competitive bradykinin B2 receptor antagonist as shown in classical pharmacological preparations with no activity in the rabbit a...

journal_title：European journal of pharmacology

authors： Wirth KJ,Schölkens BA,Wiemer G

更新日期：1994-12-15 00:00:00

abstract：:A mixture of dexamphetamine and chlordiazepoxide induces hyperactivity in both mice and rats. This type of hyperactivity has been proposed as an animal model of mania. Magnesium valproate itself had little influence on the activity of normal mice and rats. Acute pretreatment of mice with magnesium valproate (75-300 mg...

journal_title：European journal of pharmacology

authors： Cao BJ,Peng NA

更新日期：1993-06-24 00:00:00

abstract：:COPD is a chronic lung disease characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities. Furthermore, COPD is often characterized by extrapulmonary manifestations and comorbidities worsening COPD progression and quality of life. A neglected comorbidity in COPD...

journal_title：European journal of pharmacology

authors： Pelgrim CE,Peterson JD,Gosker HR,Schols AMWJ,van Helvoort A,Garssen J,Folkerts G,Kraneveld AD

更新日期：2019-01-05 00:00:00

abstract：:Bradykinin (BK; 10(-10)-10(-7) M) relaxes phenylephrine-contracted rabbit isolated pulmonary arterial rings. The mechanical destruction of the endothelial layer obliterates acetylcholine (ACh) and A23187-induced relaxation without influencing BK-, isoproterenol-, sodium nitroprusside- and papaverine-induced relaxation...

journal_title：European journal of pharmacology

authors： Chand N,Mahoney TP Jr,Diamantis W,Sofia RD

更新日期：1987-06-04 00:00:00

abstract：:Adenosine (10(-4)-10(-3) M) contracted the isolated rat tail artery. This effect exhibited rapidly developing tachyphylaxis. Methysergide (10(-7) M) prevented the contractile response to adenosine and 5-hydroxytryptamine (5-HT) without affecting that to noradrenaline. Pretreatment of rats with parachlorophenylalanine ...

journal_title：European journal of pharmacology

authors： Brown CM,Collis MG

更新日期：1981-12-03 00:00:00

abstract：:To investigate the significance of endogenous, neuroleptic-like gamma-type endorphins and their putative receptors, polyclonal and monoclonal antibodies against gamma-type endorphins, which may bio-inactivate the ligands for the receptors, and monoclonal anti-idiotype antibodies, which presumably bind to the receptors...

journal_title：European journal of pharmacology

authors： Van Ree JM,Wolterink G,Igarashi Y,Vanderschuren L,Wiegant VM,Rust CJ,Bruning HW

更新日期：1995-06-12 00:00:00