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Methamphetamine selectively alters brain glutathione.

Abstract：

:As methamphetamine-induced neurotoxicity has been proposed to involve oxidative stress, reduced and oxidized glutathione (GSH and GSSG, respectively), vitamin E and ascorbate were measured in the striata of rats killed 2 or 24 h after a neurotoxic regimen of methamphetamine. At 2 h, methamphetamine increased GSH and GSSG (32. 5% and 43.7%, respectively) compared to controls at 2 h. No difference was seen in glutathione at 24 h, and in vitamin E and ascorbate at either time point. These findings indicate selectivity of methamphetamine for the glutathione system and a role for methamphetamine in inducing oxidative stress.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Harold C,Wallace T,Friedman R,Gudelsky G,Yamamoto B

doi

10.1016/s0014-2999(00)00392-7

keywords:

subject

Has Abstract

pub_date

2000-07-14 00:00:00

pages

99-102

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(00)00392-7

journal_volume

400

pub_type

杂志文章

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