The inhibitory effect of opioid and alpha 2-adrenoceptor agonists on cardiac sensory neurones is pertussis toxin-insensitive.

abstract：:Acute dystonic reactions are motor side effects that occur soon after the initiation of neuroleptic treatment. Although earlier studies indicate that these abnormal movements can be induced in animals and humans via activation of sigma receptors, the relative contribution of the different sigma receptor subtypes is un...

journal_title：European journal of pharmacology

authors： Matsumoto RR,Pouw B

更新日期：2000-08-04 00:00:00

abstract：:We have studied the ability of various uptake blockers to protect the dopamine neuronal carrier labeled with [3H]GBR 12783 (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-(propenyl)-piperazine) against N-ethylmaleimide-induced alkylation, using membrane preparations obtained from rat striatum. Pure uptake inhibitors such ...

journal_title：European journal of pharmacology

authors： Héron C,Costentin J,Bonnet JJ

更新日期：1994-11-03 00:00:00

abstract：:The activity of angiotensin-converting enzyme in rat choroid plexus was higher than that of any other organ, being 6--7 times higher than that in lung and more than 50 times higher than in any other region of brain. Rabbit choroid plexus also had high activity of enzyme while that of human choroid plexus was relativel...

journal_title：European journal of pharmacology

authors： Arregui A,Iversen LL

更新日期：1978-11-01 00:00:00

abstract：:The stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W.1419), which was promising in inflammatory bowel disease (PL-10, PLD-116, PL-14736, Pliva) trials, protects against both acute and chronic alcohol-induced lesions in stomach and liver, but also, given peripherally, affects various centrally mediated dis...

journal_title：European journal of pharmacology

authors： Blagaic AB,Blagaic V,Romic Z,Sikiric P

更新日期：2004-09-24 00:00:00

abstract：:The response of lymph vessels, arterioles and venules in the exteriorized rat mesentery to endothelin-1, vasopressin and norepinephrine was examined with the aid of high-resolution television microscopy. On a molar basis, endothelin-1 was more potent than vasopressin to contract the three types of vessels. Norepinephr...

journal_title：European journal of pharmacology

authors： Fortes ZB,Scivoletto R,Garcia-Leme J

更新日期：1989-10-24 00:00:00

abstract：:Anthracycline derivatives including 4'-epidoxorubicin are known to cause cardiovascular side effects. In this study we examined the effects of 4'-epidoxorubicin on sympathetic nerves of rat tail artery in vitro. Treatment with 4'-epidoxorubicin at concentrations higher than 10 microM gradually increased the resting te...

journal_title：European journal of pharmacology

authors： Sakai T,Inagaki R,Taniguchi T,Shinozuka K,Kunitomo M,Hayashi N,Ishii Y,Muramatsu I

更新日期：1998-08-28 00:00:00

abstract：:The purposes of the present study were to clarify whether some Cl(-) channels exist in rat pleural mesothelial cells, and to investigate functional and molecular characteristics of these channels. Electrophysiological recordings were performed at room temperature using the whole-cell configuration of the patch-clamp t...

journal_title：European journal of pharmacology

authors： Yoshise Y,Ito K,Tsubone H,Kuwahara M

更新日期：2009-07-01 00:00:00

abstract：:Since the melanocortin MC3 and melanocortin MC4 receptors are the main melanocortin receptor subtypes expressed in rat brain, we characterized the activity and affinity of nine melanocortin receptor ligands using these receptors in vitro, as well as their activity in a well-defined melanocortin-induced behavior in the...

journal_title：European journal of pharmacology

authors： Adan RA,Szklarczyk AW,Oosterom J,Brakkee JH,Nijenhuis WA,Schaaper WM,Meloen RH,Gispen WH

更新日期：1999-08-13 00:00:00

abstract：:Luminal exposure of mouse ileal mucosal sheets in vitro to 0.3% Triton X-100 for 10 min resulted in a 45.3 +/- 4.4% decrease in tissue resistance (Rt). Luminal pretreatment of tissue with epidermal growth factor (EGF, 30 nM) reduced the Triton X-100-induced decrease in Rt to 10.2 +/- 3.5%. This effect of luminal EGF w...

journal_title：European journal of pharmacology

authors： Rao R,Porreca F

更新日期：1996-05-15 00:00:00

abstract：:Secondary hyperparathyroidism is a common complication in patients with chronic kidney disease and frequently persists after kidney transplantation. Paricalcitol, a selective vitamin D receptor activator, is indicated in the management of this disorder and recent evidences have suggested that this drug has other benef...

journal_title：European journal of pharmacology

authors： Pérez V,Sánchez-Escuredo A,Lauzurica R,Bayés B,Navarro-Muñoz M,Pastor MC,Cañas L,Bonet J,Romero R

更新日期：2013-06-05 00:00:00

abstract：:Systemic administration of the active, sulfated form of cholecystokinin-octapeptide (CCK-8S), at a dose known to inhibit dopamine (DA) release, significantly reduced the latency to ejaculate and number of intromissions preceding ejaculation in sexually active male rats. This effect was identical to that reported for l...

journal_title：European journal of pharmacology

authors： Pfaus JG,Phillips AG

更新日期：1987-09-23 00:00:00

abstract：:CysLT1 receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT2 receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs and use this mod...

journal_title：European journal of pharmacology

authors： Sekioka T,Kadode M,Yonetomi Y,Kamiya A,Fujita M,Nabe T,Kawabata K

更新日期：2017-01-05 00:00:00

abstract：:The quantitative [14C]iodoantipyrine autoradiographic method was applied to study the effects of acute administration of caffeine and L-phenylisopropyladenosine (LPIA) separately or in combination on local cerebral blood flow in the rat. After the injection of caffeine, cerebral blood flow rates were decreased in 13 o...

journal_title：European journal of pharmacology

authors： Nehlig A,Pereira de Vasconcelos A,Dumont I,Boyet S

更新日期：1990-04-25 00:00:00

abstract：:Neurotensin is a neuropeptide associated with basal ganglia dopaminergic neurons. Because levels of neurotensin in striatal tissue are differentially affected by low or high doses of methamphetamine, we employed microdialysis to assess the dose-dependent effects of methamphetamine on neurotensin release from the termi...

journal_title：European journal of pharmacology

authors： Frankel PS,Hoonakker AJ,Hanson GR,Bush L,Keefe KA,Alburges ME

更新日期：2005-10-17 00:00:00

abstract：:The overactivation of glutamate receptors is a major cause of Ca(2+) overload in cells, potentially leading to cell damage and death. There is an abundance of agents and mechanisms by which glutamate receptor activation can be prevented or modulated in order to control these effects. They include the well-established,...

journal_title：European journal of pharmacology

authors： Stone TW,Addae JI

更新日期：2002-07-05 00:00:00

abstract：:Recently, it has been shown that release of cytochrome c from the mitochondria to the cytosol is required for activation of the caspase-3-dependent cascade in apoptosis, and also for alpha-synuclein aggregation. In the present study, we examined the effects of talipexole and pramipexole on the release of cytochrome c ...

journal_title：European journal of pharmacology

authors： Kakimura J,Kitamura Y,Takata K,Kohno Y,Nomura Y,Taniguchi T

更新日期：2001-04-06 00:00:00

abstract：:The present study was undertaken to compare the properties of the [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) binding site in the dorsal raphe nucleus with the hippocampal 5-HT1A receptor. In both tissues inclusion of 1 mM Mg2+ enhanced specific [3H]8-OH-DPAT binding, while 1 mM GTP decreased radioligand bi...

journal_title：European journal of pharmacology

authors： Johnson RG,Fiorella D,Winter JC,Rabin RA

更新日期：1997-06-18 00:00:00

abstract：:We examined the effects of the administration of 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-pregna-1,4,9( 11)-triene-3,20-dione, monomethansulfonate (U74389F), a 21-aminosteroid and so-called lazaroid, that is characterized by an inhibitory activity against iron-dependent lipid peroxidation, on ischemi...

journal_title：European journal of pharmacology

authors： Paroni R,De Vecchi E,Lubatti L,Conti E,Beretta C,Rinaldi P,Kienle MG,Trazzi R

更新日期：1995-12-29 00:00:00

abstract：:The effect of propionyl-L-carnitine, an analogue of L-carnitine, and insulin on the oscillatory potentials of the electroretinogram was determined in rats with streptozotocin-induced diabetes. Propionyl-L-carnitine was administered at a daily dose of 0.5 g/kg by gavage for 4 weeks, while other rats were treated with s...

journal_title：European journal of pharmacology

authors： Hotta N,Koh N,Sakakibara F,Nakamura J,Hamada Y,Hara T,Fukasawa H,Kakuta H,Sakamoto N

更新日期：1996-09-12 00:00:00

abstract：:Electrical field stimulation of the isolated adventitial and intima-medial layers of rabbit aorta preloaded with 3H-noradrenaline elicited a 3H outflow. The initial 3H outflow from adventitia was independent of external Ca2+ concentration. Each of the subsequent 3H outflows was mainly Ca2+ sensitive. All stimulation-i...

journal_title：European journal of pharmacology

authors： Schrold J,Nedergaard OA

更新日期：1976-10-01 00:00:00

abstract：:The present study examines the effect of three adenosine receptor antagonists on tremulous jaw movements (TJMs), an animal model of tremor. Forty-five rats were pre-treated with one adenosine antagonist: caffeine (0.0, 5.0, or 10.0 mg/kg; non-selective adenosine receptor antagonist), 8-cyclopentyltheophylline (CPT; 0....

journal_title：European journal of pharmacology

authors： Johnson JA,Montgomery AP,Starr ER,Ludwig J,Trevitt J

更新日期：2018-08-15 00:00:00

abstract：:We have recently shown that short-term aortic barodenervation diminishes constrictor responses to activation of alpha1-adrenoceptors in rat aortic smooth muscle. This study investigated the potential role of vascular endothelium and its derived vasoactive substances, nitric oxide and prostaglandins, in the reduced alp...

journal_title：European journal of pharmacology

authors： El-Mas MM,Daabees TT,El-Gowelli HM,Abdel-Galil AG

更新日期：1997-10-22 00:00:00

abstract：:The pharmacological profile of (+/-)-domesticine, a novel alpha(1)-adrenoceptor antagonist, was examined in animal tissues and Chinese hamster ovary (CHO) cells expressing cloned human alpha(1)-adrenoceptor subtypes and compared with the properties of BMY-7378 ([8-(2-[4-(2-methoxy-phenyl)-1-piperazinyl]ethyl)-8-azaspi...

journal_title：European journal of pharmacology

authors： Indra B,Matsunaga K,Hoshino O,Suzuki M,Ogasawara H,Muramatsu I,Taniguchi T,Ohizumi Y

更新日期：2002-06-07 00:00:00

abstract：:Portulaca oleracea L. is used as a folk medicine in many countries because of its wide range of pharmacological effects. HM-chromanone, isolated from P. oleracea using bioassay-guided fractionation and HPLC, belongs to the homoisoflavonoid group and has been shown to exert several biological effects. In this study, we...

journal_title：European journal of pharmacology

authors： Je JY,Park JE,Seo Y,Han JS

更新日期：2021-02-05 00:00:00

abstract：:Defibrotide, a polydeoxyribonucleotide obtained from mammalian lungs, reduced in a dose-dependent fashion the ischemic contracture due to low perfusion (0.2 ml/min) of isovolumic left heart of rabbit and abolished the irregular rhythm of the heart, thereby restoring the cardiomechanical activity upon reperfusion (20 m...

journal_title：European journal of pharmacology

authors： Berti F,Rossoni G,Omini C,Folco G,Daffonchio L,Viganó T,Tondo C

更新日期：1987-03-31 00:00:00

abstract：:Adenosine (10(-4)-10(-3) M) contracted the isolated rat tail artery. This effect exhibited rapidly developing tachyphylaxis. Methysergide (10(-7) M) prevented the contractile response to adenosine and 5-hydroxytryptamine (5-HT) without affecting that to noradrenaline. Pretreatment of rats with parachlorophenylalanine ...

journal_title：European journal of pharmacology

authors： Brown CM,Collis MG

更新日期：1981-12-03 00:00:00

abstract：:The activation of adenosine A(2B) receptors in human mast cells causes pro-inflammatory responses such as the secretion of interleukin-8. There is evidence for an inhibitory effect of benzodiazepines on mast cell mediated symptoms in patients with systemic mast cell activation disease. Therefore, we investigated the e...

journal_title：European journal of pharmacology

authors： Hoffmann K,Xifró RA,Hartweg JL,Spitzlei P,Meis K,Molderings GJ,von Kügelgen I

更新日期：2013-01-30 00:00:00

abstract：:Intravenous infusions of sodium nitroprusside (SNP) at doses of 20, 40 or 80 micrograms/kg min-1 for 30 min produced dose-related decrements in blood pressure in conscious rats fitted with indwelling aortic and vena caval catheters. Immediately upon termination of SNP infusions, blood pressure rebounded to levels whic...

journal_title：European journal of pharmacology

authors： Abukhres MM,Ertel RJ,Dixit BN,Vollmer RR

更新日期：1979-10-01 00:00:00

abstract：:The effect of systemic administration of the nonselective dopamine receptor agonist apomorphine on efflux of serotonin (5-hydroxytryptamine, 5-HT) in striatum and hippocampus of freely moving rats was examined using in vivo microdialysis. 5-HT efflux was increased by a moderate dose of apomorphine sufficient for a pos...

journal_title：European journal of pharmacology

authors： Mendlin A,Martín FJ,Jacobs BL

更新日期：1998-06-26 00:00:00

abstract：:Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents. As this potentiation by lithium is reversed by the administration of myo-inositol, the potentiation may be mediated by inhibition of inositol monophosphatase (IMPase), a known ...

journal_title：European journal of pharmacology

authors： Singh N,Serres F,Toker L,Sade Y,Blackburn V,Batra AS,Saiardi A,Agam G,Belmaker RH,Sharp T,Vasudevan SR,Churchill GC

更新日期：2020-09-15 00:00:00