Effect of nifedipine on cyclosporine A-induced nephrotoxicity, urinary endothelin excretion and renal endothelin receptor number.

Abstract:

:The aim of the present study was to determine the effect of a calcium channel blocker on renal function, urinary endothelin excretion and endothelin receptor number in rats. Administration of cyclosporine resulted in a significant impairment of renal function when measured by either [14C]inulin or 24 h creatinine clearances. This nephrotoxicity was associated with statistically significant (P less than 0.05) increases in urinary endothelin excretion and renal endothelin receptor number. Treatment with nifedipine attenuated cyclosporine A-induced renal dysfunction and reduced urinary endothelin excretion. The data provide further evidence of a role for endothelin in cyclosporine A-induced nephrotoxicity.

journal_name

Eur J Pharmacol

authors

Brooks DP,Ohlstein EH,Contino LC,Storer B,Pullen M,Caltabiano M,Nambi P

doi

10.1016/0014-2999(91)90132-a

keywords:

subject

Has Abstract

pub_date

1991-02-26 00:00:00

pages

115-7

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(91)90132-A

journal_volume

194

pub_type

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