Effect of nifedipine on cyclosporine A-induced nephrotoxicity, urinary endothelin excretion and renal endothelin receptor number.

abstract：:The effect of Ca2+ on the oxytocin-induced, sustained contraction of rat uterine muscle in Ca-free medium after prolonged incubation with 3 mM EGTA (Ca-free contraction) was investigated. A micromolar concentration of Ca2+ caused phasic contraction followed by relaxation while a submicromolar concentration caused rela...

journal_title：European journal of pharmacology

authors： Matsuo K,Uchida MK

更新日期：1987-08-21 00:00:00

abstract：:We previously reported that intracerebroventricularly (i.c.v.) administered (±)-epibatidine (a potent agonist of nicotinic acetylcholine receptors) (1, 5 and 10 nmol/animal) dose-dependently elevated plasma levels of noradrenaline and adrenaline and that this response was reduced by i.c.v. administered indomethacin (c...

journal_title：European journal of pharmacology

authors： Shimizu T,Tanaka K,Nakamura K,Taniuchi K,Yokotani K

更新日期：2012-09-15 00:00:00

abstract：:In previous studies using Fos expression as a marker of neuronal activation, we showed that nitrous oxide (N(2)O) activates bulbospinal noradrenergic neurons in rats and that destruction of these neuronal pathways leads to loss of N(2)O antinociceptive action. Based on previous rat studies it has been proposed that th...

journal_title：European journal of pharmacology

authors： Kingery WS,Sawamura S,Agashe GS,Davies MF,Clark JD,Zimmer A

更新日期：2001-09-07 00:00:00

abstract：:Pteropodine and isopteropodine are heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC, a Peruvian medicinal plant known as cat's claw. In this study, the effects of these alkaloids on the function of Ca(2+)-activated Cl(-) currents evoked by stimulation of G protein-coupled muscarinic M...

journal_title：European journal of pharmacology

authors： Kang TH,Matsumoto K,Tohda M,Murakami Y,Takayama H,Kitajima M,Aimi N,Watanabe H

更新日期：2002-05-24 00:00:00

abstract：:T-type Ca(2+) currents were recorded in 2 mM Ca(2+) from HEK293 cells stably expressing the low voltage-activated Ca(2+) channel sub-unit alpha(1I). These currents were inhibited by the known Ca(2+) channel antagonist mibefradil with an IC(50) close to 1 microM. SB-209712 (1,6,bis¿1-[4-(3-phenylpropyl)piperidinyl]¿hex...

journal_title：European journal of pharmacology

authors： McNaughton NC,Warre R,Cooper DG,Nasir S,Ranson JL,Randall A

更新日期：2000-10-27 00:00:00

abstract：:Due to the limited results achieved in the clinical treatment of heart failure, a new inotropic strategy of myosin motor activation has been developed. The lead molecule of myosin activator agents is omecamtiv mecarbil, which binds directly to the heavy chain of the cardiac β-myosin and enhances cardiac contractility ...

journal_title：European journal of pharmacology

authors： Nánási P Jr,Gaburjakova M,Gaburjakova J,Almássy J

更新日期：2017-08-15 00:00:00

abstract：:Malfunction of the serotonergic system and dysregulation of the hypothalamo-pituitary-adrenocortical axis have been implicated in the pathophysiology of depression. Several studies provide evidence for reciprocal influences between glucocorticoids and 5-HT receptors. The effect of repeated treatment with a high dose o...

journal_title：European journal of pharmacology

authors： Berendsen HH,Kester RC,Peeters BW,Broekkamp CL

更新日期：1996-07-18 00:00:00

abstract：:Glial cells express thromboxane A(2) receptor, but its physiological role remains unknown. The present study was performed to examine thromboxane A(2) receptor-mediated morphological change in 1321N1 human astrocytoma cells. Thromboxane A(2) receptor agonists U46619 and STA(2) caused a rapid morphological change to sp...

journal_title：European journal of pharmacology

authors： Honma S,Saika M,Ohkubo S,Kurose H,Nakahata N

更新日期：2006-09-18 00:00:00

abstract：:An excess of lipids may accumulate in the kidney in conditions such as diabetes and hypertension, and can potentially cause renal injury. We previously reported that an infusion of angiotensin II into a rat induced deposition of lipids in the renal tubular epithelial cells. Here we have examined the effect of pioglita...

journal_title：European journal of pharmacology

authors： Sakamoto A,Hongo M,Saito K,Nagai R,Ishizaka N

更新日期：2012-05-05 00:00:00

abstract：:Skeletal myogenesis comprises myoblast replication and differentiation into striated multinucleated myotubes. Agents that interfere with myoblast replication are important tools for the understanding of myogenesis. Recently, we showed that cholesterol depletion by methyl-β-cyclodextrin (MCD) enhances the differentiati...

journal_title：European journal of pharmacology

authors： Portilho DM,Soares CP,Morrot A,Thiago LS,Butler-Browne G,Savino W,Costa ML,Mermelstein C

更新日期：2012-11-05 00:00:00

abstract：:Toll-like receptors (TLRs) play an important role in the recognition of microbial pathogens and induce innate immune responses. The recognition of microbial components by TLRs triggers the activation of myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter inducing interfero...

journal_title：European journal of pharmacology

authors： Gu GJ,Eom SH,Suh CW,Koh KO,Kim DY,Youn HS

更新日期：2013-12-05 00:00:00

abstract：:Morphine produces a state dependent learning. The hippocampus is involved in this kind of learning. Gap junctions (GJs) are involved in some of the effects of morphine and exist in different areas of the hippocampus. We investigated the effects of blocking GJ channels of the hippocampal CA1 area, by means of pre-test ...

journal_title：European journal of pharmacology

authors： Beheshti S,Hosseini SA,Noorbakhshnia M,Eivani M

更新日期：2014-12-15 00:00:00

abstract：:Termination of signalling by G-protein-coupled receptors requires inactivation of the G alpha-subunits of heterotrimeric G-proteins and the re-association of G alpha- and G betagamma-subunits. Inactivation of G alpha-subunits is achieved by the hydrolysis of bound GTP by an intrinsic GTPase activity, which is consider...

journal_title：European journal of pharmacology

authors： Karakoula A,Tovey SC,Brighton PJ,Willars GB

更新日期：2008-06-10 00:00:00

abstract：:Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect, whereas eNOS-derived N...

journal_title：European journal of pharmacology

authors： Atef Y,El-Fayoumi HM,Abdel-Mottaleb Y,Mahmoud MF

更新日期：2017-11-15 00:00:00

abstract：:Bupropion is a weakly potent central nervous system (CNS) stimulant that is marketed both as an antidepressant and as an anti-smoking aid. The mechanism(s) by which it produces its effects is not well understood. In the present study, the effect of bupropion was examined in rats trained to discriminate the stimulus ef...

journal_title：European journal of pharmacology

authors： Young R,Glennon RA

更新日期：2002-05-17 00:00:00

abstract：:The effects of intra- and extraluminal capsaicin administration were evaluated in isolated perfused rat mesenteric bed. Capsaicin (10 nM-1 microM) produced a potent concentration-dependent relaxation of the tonic vasoconstriction induced by norepinephrine (1 microM) but not by high-K+ (60 mM). The capsaicin-induced re...

journal_title：European journal of pharmacology

authors： Manzini S,Perretti F

更新日期：1988-03-29 00:00:00

abstract：:Ulcerative colitis (UC), as an autoimmune disease, has been troubling human health for many years. Up to now, the available treatments remain unsatisfactory. Rhizoma Coptidis has been widely applied to treat gastrointestinal diseases in China for a long time, and coptisine (COP) is identified as one of its major activ...

journal_title：European journal of pharmacology

authors： Wang Y,Liu J,Huang Z,Li Y,Liang Y,Luo C,Ni C,Xie J,Su Z,Chen J,Li C

更新日期：2021-01-25 00:00:00

abstract：:Increased O-Linked β-N-acetylglucosamine (O-GlcNAc) is observed in several pathologies, and unbalanced O-GlcNAcylation levels favor endothelial dysfunction. Whether augmented O-GlcNAc impacts the uterine artery (UA) function and how it affects the UA during pregnancy remains to be elucidated. We hypothesized that gluc...

journal_title：European journal of pharmacology

authors： Dela Justina V,Priviero F,Dos Passos RR Jr,Webb RC,Lima VV,Giachini FR

更新日期：2020-08-05 00:00:00

abstract：:Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive Ca2+-permeable channel. The activation of TRPM2 by H2O2 causes cell death in various types of cells. 5-Fluorouracil (5-FU) is an important anticancer drug, but myelosuppression is one of the most frequent adverse effects. The involvemen...

journal_title：European journal of pharmacology

authors： Ishibashi M,Ishii M,Yamamoto S,Mori Y,Shimizu S

更新日期：2021-01-15 00:00:00

abstract：:Pretreatment with the non-competitive NMDA (N-methyl-D-aspartate) antagonist MK801 (0.5, 1.0 mg/kg, s.c.) suppressed the behavioral signs of withdrawal in morphine-dependent rats. However, the same doses of MK801 that suppressed morphine withdrawal also simultaneously produced phencyclidine (PCP)-like behaviors. Pretr...

journal_title：European journal of pharmacology

authors： Rasmussen K,Fuller RW,Stockton ME,Perry KW,Swinford RM,Ornstein PL

更新日期：1991-05-02 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Despite the impact of this pathology in the population, nowadays there is no specific treatment for this disease, focusing its treatment on risks factors. However, it is imperative the existence of a specific treatment, due to this...

journal_title：European journal of pharmacology

authors： de Jesús Acosta-Cota S,Aguilar-Medina EM,Ramos-Payán R,Rendón Maldonado JG,Romero-Quintana JG,Montes-Avila J,Sarmiento-Sánchez JI,Plazas-Guerrero CG,Vergara-Jiménez MJ,Sánchez-López A,Centurión D,Osuna-Martínez U

更新日期：2019-11-15 00:00:00

abstract：:In the present study, the inhibitory effects of hesperetin (HSP) on human cardiac Kv1.5 channels expressed in HEK 293 cells and the ultra-rapid delayed rectifier K(+) current (Ikur) in human atrial myocytes were examined by using the whole-cell configuration of the patch-clamp techniques. We found that hesperetin rapi...

journal_title：European journal of pharmacology

authors： Wang H,Wang HF,Wang C,Chen YF,Ma R,Xiang JZ,Du XL,Tang Q

更新日期：2016-10-15 00:00:00

abstract：:Angiogenesis is critical for re-establishing blood supply to the ischemic myocardium after acute myocardial infarction (AMI). This study aimed to investigate the effects of morroniside on angiogenesis after AMI and explored associated proangiogenic mechanisms. A rat model of AMI was established by ligation of the left...

journal_title：European journal of pharmacology

authors： Liu T,Sun F,Cui J,Zheng S,Li Z,Guo D,Tian X,Zhu Z,Zheng W,Wang Y,Wang W

更新日期：2020-04-05 00:00:00

abstract：:We have made extracellular recordings from locus coeruleus neurones contained in a pontine slice preparation. The in vitro technique permits application of known concentrations of drugs in the perfusion medium. Substance P excites locus coeruleus neurones in a concentration-dependent manner. The activity of substance ...

journal_title：European journal of pharmacology

authors： Cheeseman HJ,Pinnock RD,Henderson G

更新日期：1983-10-14 00:00:00

abstract：:Sirolimus and paclitaxel eluted from stents inhibit cell proliferation and other cellular processes by dramatically different mechanisms. In this study, the effects of sirolimus and paclitaxel on cultured human coronary artery smooth muscle and endothelial cell function or cell cycle changes in balloon-injured arterie...

journal_title：European journal of pharmacology

authors： Parry TJ,Brosius R,Thyagarajan R,Carter D,Argentieri D,Falotico R,Siekierka J

更新日期：2005-11-07 00:00:00

abstract：:In this study, we describe the effect of antiepileptic drugs on the production of kynurenic acid in rat cortical slices, and on the activity of kynurenic acid biosynthetic enzymes, kynurenine aminotransferases (KATs I and II) in the brain tissue. Phenobarbital, felbamate, phenytoin and lamotrigine (all at 0.5-3.0 mM) ...

journal_title：European journal of pharmacology

authors： Kocki T,Wielosz M,Turski WA,Urbanska EM

更新日期：2006-07-17 00:00:00

abstract：:(+/-)3,4-Methylenedioxymethamphetamine (MDMA) was administered to rats as a single 40 mg/kg injection s.c. or 40 mg/kg s.c. every second day for 4 injections. Sixteen days following the last injection rats were killed. MDMA produced significant depletions of 5-HT and its metabolite 5-HIAA in the hippocampus and the fr...

journal_title：European journal of pharmacology

authors： Mokler DJ,Robinson SE,Rosecrans JA

更新日期：1987-06-19 00:00:00

abstract：:Cd2+ competitively antagonizes Ca2+ in the evoked release of acetylcholine from nerve terminals in the frog sciatic-sartorius neuromuscular junction. The dissociation constant between Cd2+ and its receptor sites was calculated to be 1.7 microM. In agreement with previous work we found that brief exposures to 100-500 m...

journal_title：European journal of pharmacology

authors： Cooper GP,Manalis RS

更新日期：1984-04-06 00:00:00

abstract：:Pyrethroid insecticides have been reported to increase transmembrane sodium influx and inhibit ion-dependent ATPases in insect, squid, and toad nerve tissues. Since changes in sarcolemmal ion fluxes and inhibition of membrane-bound ATPases can alter myocardial contractility, the effects of a potent synthetic pyrethroi...

journal_title：European journal of pharmacology

authors： Berlin JR,Akera T,Brody TM,Matsumura F

更新日期：1984-03-02 00:00:00

abstract：:An in vitro method was developed for the biochemical and autoradiographic demonstration of low muscarinic receptor densities in peripheral tissue. Histological criteria point clearly to the necessity for fixation to preserve tissue quality. [3H]l-Quinuclidinylbenzilate bound specifically to a homogeneous class of bind...

journal_title：European journal of pharmacology

authors： Van Megen YJ,Teunissen MJ,Klaassen AB,Rodrigues de Miranda JF

更新日期：1988-01-05 00:00:00