Abstract:
:Overproduction of the free radical nitric oxide (NO) has been implicated in the pathogenesis of a variety of inflammatory and immunologically mediated diseases as well as complications of diabetes. In the present study we have demonstrated that aminoguanidine selectively inhibits the cytokine-inducible isoform of NO synthase which appears to be responsible for the excess production of NO linked to these disease states. By using organ, cell, and enzyme-based measurements we have shown that aminoguanidine is equipotent to NG-monomethyl-L-arginine (L-NMA) as an inhibitor of the cytokine-induced isoform of NO synthase but is 10 to 100-fold less potent as an inhibitor of the constitutive isoform. Thus, aminoguanidine may be useful as a selective inhibitor of the inducible NO synthase in the treatment of disease states characterized by the pathological overproduction of NO.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Misko TP,Moore WM,Kasten TP,Nickols GA,Corbett JA,Tilton RG,McDaniel ML,Williamson JR,Currie MGdoi
10.1016/0014-2999(93)90357-nsubject
Has Abstractpub_date
1993-03-16 00:00:00pages
119-25issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(93)90357-Njournal_volume
233pub_type
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