Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine.

abstract：:FR134043, disodium(Z,1S,15S,8S,24S,27R,29S,34S,37R)-29-ben zyl-21-ethylidene-27-hydroxy-15-isobutyrylamino-34-isopropyl-31,37 -dimethyl-10,16,19,22,30,32,35,38-octaoxo-36-oxa-9,11,17,20,23,28, 31,33-octaazatetracyclo[16.13.6.1(24),(28).0(3),(8)]octatricont a-3,5,7-trien-5,6-diyl disulfate, is a water-soluble inhibitor...

journal_title：European journal of pharmacology

authors： Shinguh Y,Yamazaki A,Inamura N,Fujie K,Okamoto M,Nakahara K,Notsu Y,Okuhara M,Ono T

更新日期：1998-03-26 00:00:00

abstract：:The intravenous injection of loperamide induced an immediate fall in blood pressure and heart rate in anaesthetized rats. Both effects were inhibited by the opiate antagonists naloxone and MRZ 2266 BS. Bilateral vagotomy also inhibited both effects whereas atropine only reduced the bradycardia, but the combination of ...

journal_title：European journal of pharmacology

authors： Gautret B,Schmitt H

更新日期：1985-01-02 00:00:00

abstract：:Neuropeptide Y has direct vasoconstrictor actions and potentiates the effects of other vasoconstrictor agents. To find out whether both effects of neuropeptide Y are mediated via the same receptor and intracellular mechanism, the interaction between neuropeptide Y and angiotensin II was studied in rabbit femoral arter...

journal_title：European journal of pharmacology

authors： Cressier F,Criscione L,Hofbauer KG

更新日期：1995-01-05 00:00:00

abstract：:The beta-amyloid peptide-(25-35) fragment, but not beta-amyloid peptide-(1-28), shares with beta-amyloid protein-(1-42) the ability to self-aggregate and to induce neurotoxicity in vitro. This study examined the induction of amnesia in rats given intracerebroventricularly soluble or aggregated beta-amyloid peptide-(25...

journal_title：European journal of pharmacology

authors： Delobette S,Privat A,Maurice T

更新日期：1997-01-14 00:00:00

abstract：:Bitter taste receptors (Tas2rs) initiate a bitter taste signaling involving the activation of taste-specific G protein gustducin and phosphodiesterases (PDEs); it leads to the decrease of cytosolic level of cyclic adenosine monophosphate (cAMP) in taste cells. Recent studies have identified the expression of Tas2rs in...

journal_title：European journal of pharmacology

authors： Liu M,Qian W,Subramaniyam S,Liu S,Xin W

更新日期：2020-04-05 00:00:00

abstract：:The actions of carbachol were studied on the firing response of neostriatal neurons recorded intracellularly from in vitro slice preparations of the rat brain. Carbachol (1-10 microM) reversibly reduced the afterhyperpolarization in neostriatal neurons. This effect was accompanied by an increase in both firing frequen...

journal_title：European journal of pharmacology

authors： Pineda JC,Bargas J,Flores-Hernández J,Galarraga E

更新日期：1995-08-15 00:00:00

abstract：:The use-dependent effects of bunazosin on the maximal rate of rise (Vmax) of the action potential and conduction velocity were studied in isolated papillary muscles of guinea-pig. Standard microelectrode techniques were used to monitor the conduction and action potential of the muscles. In the presence of 30 microM bu...

journal_title：European journal of pharmacology

authors： Hasegawa J,Noguchi N,Sawaguchi M,Doi T,Hisatome I,Kotake H,Mashiba H

更新日期：1990-12-04 00:00:00

abstract：:In neuropathic rats sensitive to phentolamine (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insen...

journal_title：European journal of pharmacology

authors： Kim SK,Min BI,Kim JH,Hwang BG,Yoo GY,Park DS,Na HS

更新日期：2005-10-31 00:00:00

abstract：:Nitric oxide (NO) has been described to exert various anti-atherogenic actions. However, NO, in some cases, has been shown to stimulate the oxidation of low-density lipoprotein (LDL), which constitute an important triggering event in atherosclerosis. Thus, some NO donors, despite their advantages, might also induce ox...

journal_title：European journal of pharmacology

authors： Jaworski K,Kinard F,Goldstein D,Holvoet P,Trouet A,Schneider YJ,Remacle C

更新日期：2001-08-03 00:00:00

abstract：:Neuroinflammation contributes to the pathogenesis of neurological disorders including stroke, head trauma, multiple sclerosis, amyotrophic lateral sclerosis as well as age-associated neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Therefore, anti-inflammatory drugs could be used to slow the...

journal_title：European journal of pharmacology

authors： Madeira JM,Beloukhina N,Boudreau K,Boettcher TA,Gurley L,Walker DG,McNeil WS,Klegeris A

更新日期：2012-02-15 00:00:00

abstract：:Here we investigated the effect of naloxone-precipitated morphine withdrawal on the release of noradrenaline in hippocampus of the anaesthetised rat. Naloxone (1 mg/kg i.p.) injected 3 and 24 h, but not 3 weeks, after eight daily injections of morphine, induced an immediate increase in hippocampal noradrenaline releas...

journal_title：European journal of pharmacology

authors： Done C,Silverstone P,Sharp T

更新日期：1992-05-14 00:00:00

abstract：:We explored the effects of contractile arrest maintained for 24-72 h in the presence of 2,3-butanedione monoxime or a Ca(2+) channel blocker (nifedipine or verapamil) on contractile activity, Ca(i)(2+) transients, and myofibrillar protein content and ultrastructure in long-term cultures of spontaneously beating adult ...

journal_title：European journal of pharmacology

authors： Horackova M,Byczko Z,Morash B

更新日期：2000-09-22 00:00:00

abstract：:In this study, we have examined the effect of acute and chronic administration of LY 277359, a putative 5-HT3 receptor antagonist, on the number of spontaneously active dopamine cells in the substantia nigra pars compacta (SNC or A9) and ventral tegmental area (VTA or A10). This was accomplished using the standard ext...

journal_title：European journal of pharmacology

authors： Minabe Y,Ashby CR Jr,Wang RY

更新日期：1991-12-17 00:00:00

abstract：:Mitochondrial DNA mutations promote hypertensive renal dysfunction, but the molecular mechanism remains unclear. This study compared renal damage between spontaneously hypertensive rats (SHR) and SHR with mitochondrial transfer (t)RNA mutations. To investigate the role of mitochondrial outer membrane voltage-dependent...

journal_title：European journal of pharmacology

authors： Zhu C,Tian L,Yang H,Chen P,Li Y,Liu Y

更新日期：2019-12-15 00:00:00

abstract：:We investigated the effects of KF19514 (5-phenyl-3-(3-pyridyl)methyl-3H-imidazo[4,5-c][1,8]naphthyridin-4 (5H)-one) on bronchoconstriction and allergic inflammation in guinea pigs and on tumor necrosis factor-alpha production in mice. KF19514 inhibited phosphodiesterase 4 (IC50 = 0.40 microM) and phosphodiesterase 1 (...

journal_title：European journal of pharmacology

authors： Manabe H,Akuta K,Sejimo H,Kawasaki H,Nukui E,Ichimura M,Kase H,Kawakita T,Suzuki F,Kitamura S,Sato S,Ohmori K

更新日期：1997-07-30 00:00:00

abstract：:Several aspects of the role of corticotropin-releasing factor (CRF) in the forced swimming test were investigated in this study by using two different administration schedules. I.c.v. microinjection of CRF produced a dose-dependent increase in swimming activity when the administration schedule originally reported for ...

journal_title：European journal of pharmacology

authors： García-Lecumberri C,Ambrosio E

更新日期：1998-02-05 00:00:00

abstract：:We have confirmed our earlier finding that most red wines are able to bring about 5-hydroxytryptamine (5-HT, serotonin) release from platelets in vitro. Platelets from individual subjects manifested varying degrees of releasing ability but responded to different wines with a similar rank ordering. There was a high cor...

journal_title：European journal of pharmacology

authors： Pattichis K,Louca LL,Jarman J,Sandler M,Glover V

更新日期：1995-01-13 00:00:00

abstract：:Behaviors induced in mice by intrathecal injections of either N-methyl-D-aspartate (NMDA) or kainic acid are modulated by NH2-terminal fragments of substance P, such as substance P-(1-7). The action of substance P-(1-7) on kainic acid depends on sigma receptor activity. The present study was designed to test the hypot...

journal_title：European journal of pharmacology

authors： Hornfeldt CS,Kitto KF,Larson AA

更新日期：1996-06-13 00:00:00

abstract：:To investigate the neurotoxicity of amyloid-beta-(25-35), which is thought to be the active site of amyloid-beta, the peptide was injected into the lateral ventricle of rats. A single intracerebroventricular (i.c.v.) injection of amyloid-beta-(25-35) at a dose of 15 nmol/rat induced a marked decrease in latency in ste...

journal_title：European journal of pharmacology

authors： Yamaguchi Y,Kawashima S

更新日期：2001-02-02 00:00:00

abstract：:These studies examined the opioid and non-opioid in vivo and in vitro actions of PD117,302 (((±)-trans-N-methyl-N-[2-(l-pyrrolidinyl)-cyclohexyl]benzo[b]thiophene-4-acetamide), a kappa (κ)-opioid receptor agonist. PD117,302 selectively labeled the κ-opioid receptor in guinea pig cerebellar membranes and in mice the ED...

journal_title：European journal of pharmacology

authors： Pugsley MK,Saint DA,Hayes ES,Abraham S,Walker MJ

更新日期：2015-08-15 00:00:00

abstract：:The mechanisms underlying the contractile effects of neuropeptide Y (NPY) in relation to those of noradrenaline (NA) on small human blood vessels were studied in vitro. NPY caused contractions of mesenteric veins, renal and skeletal muscle arteries but not of mesenteric arteries. NPY was about 5- to 10-fold more poten...

journal_title：European journal of pharmacology

authors： Pernow J,Svenberg T,Lundberg JM

更新日期：1987-04-14 00:00:00

abstract：:Thiazolidinedione and isoxazolidinedione insulin sensitizers activate peroxisome proliferator-activated receptor gamma (PPAR gamma). Some thiazolidinediones modify ion channels in smooth muscles; however, the mechanism by which their actions occur has not been clarified. We, thus, examined the effects of three thiazol...

journal_title：European journal of pharmacology

authors： Eto K,Ohya Y,Nakamura Y,Abe I,Fujishima M

更新日期：2001-06-29 00:00:00

abstract：:The effect of some tryptaminergic drugs on electroshock fighting behaviour in rats was determined. Reserpine and tetrabenazine reduced the fighting responses while 5-hydroxytryptophan increased the fighting responses in normal as well as reserpine-treated animals. p-Chlorophenylalanine, a specific depletor of brain se...

journal_title：European journal of pharmacology

authors： Anand M,Gupta GP,Bhargava KP

更新日期：1976-10-01 00:00:00

abstract：:Captivity-induced stereotypies in bank voles (Clethrionomys glareolus) were inhibited at the age of 1, 2, 4, 6, 8 and 10 months by 0.2 mg/kg haloperidol s.c., while 35 mg/kg naloxone s.c. only inhibited them at the age of 4-6 months. Other activities were not significantly inhibited. The change in the naloxone effect ...

journal_title：European journal of pharmacology

authors： Kennes D,Odberg FO,Bouquet Y,De Rycke PH

更新日期：1988-08-09 00:00:00

abstract：:The monoethyl, monopropyl and monoisopropyl esters of succinic acid, administered intravenously at the dose of 2 micromol/g body weight, were found to increase the insulinotropic action of gliquidone (0.2 nmol/g body weight) in anaesthetized rats. The monoisopropyl ester of succinic acid also doubled the hypoglycemic ...

journal_title：European journal of pharmacology

authors： García-Martínez JA,Villanueva-Peñacarrillo ML,Valverde I,Björkling F,Malaisse WJ

更新日期：1997-04-23 00:00:00

abstract：:The electrodermal potential (EDP) recorded in the forepaws of anaesthetized cats in response to stimulation of the cholinergic-sympathetic nervous system at different levels was taken as a measure for sudomotor activity. Electrical stimulation of the hypothalamus with square wave pulses (1 ms duration, 0.5-64 Hz, 2 s ...

journal_title：European journal of pharmacology

authors： Rybarczyk MC,Walland A

更新日期：1985-06-19 00:00:00

abstract：:Synthesis of the vasoconstrictor peptide endothelin-1 by endothelial and epithelial cells is strongly induced by tumor necrosis factor alpha (TNF-alpha). The actions of TNF-alpha are mediated by two transmembrane receptors of approximately 55 (p55, CD120a) and 75 kDa (p75, CD120b). Reagents activating selectively thes...

journal_title：European journal of pharmacology

authors： Lees DM,Pallikaros Z,Corder R

更新日期：2000-02-25 00:00:00

abstract：:To investigate the structure-activity relationships for potent and selective action of enkephalins at the delta-opioid receptors, two newly synthesized analogues, [Cys(O2NH2)2,Leu5]enkephalin and [Cys(O2NH2)2, Met5] enkephalin and the hexapeptide [D-Ala2,Leu5]enkephalyl-Arg (dalargin) were tested and compared with [Le...

journal_title：European journal of pharmacology

authors： Pencheva N,Bocheva A,Dimitrov E,Ivancheva C,Radomirov R

更新日期：1996-05-23 00:00:00

abstract：:Spinal glial activation contributes to the development and maintenance of chronic pain states, including neuropathic pain of diverse etiologies. Cannabinoid compounds have shown antinociceptive properties in a variety of neuropathic pain models and are emerging as a promising class of drugs to treat neuropathic pain. ...

journal_title：European journal of pharmacology

authors： Burgos E,Gómez-Nicola D,Pascual D,Martín MI,Nieto-Sampedro M,Goicoechea C

更新日期：2012-05-05 00:00:00

abstract：:Nicotine acts as an agonist of nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors play a role in the modulation of neurotransmitter release in both the central and the peripheral nervous system. Moderate reactive oxygen species levels modulate the regulation of physiological functions e.g. neurotrans...

journal_title：European journal of pharmacology

authors： Ozger Ilhan S,Sarioglu Y,Vural IM,Dileköz E,Oztürk GS,Ercan ZS

更新日期：2008-06-10 00:00:00