Vasodilation produced by prostacyclin (PGI2) and 9(O)-thiaprostacyclin (PGI2-S) in the canine femoral circulation.

abstract：:Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside with a relaxant effect on skeletal muscle, has been found to displace both [3H]gamma-aminobutyric acid ([3H]GABA) and [3H]strychnine binding, suggesting an interaction with both GABA and strychnine-sensitive glycine receptor...

journal_title：European journal of pharmacology

authors： Balduini W,Cimino M,Depoortere H,Cattabeni F

更新日期：1999-07-02 00:00:00

abstract：:GABAA and GABAB receptor agonists and antagonists were administered locally in the striatum of intact and kainic acid lesioned rats. (+/-)-Baclofen, a GABAB receptor agonist, significantly decreased the level of extracellular dopamine in the striatum of intact rats. (+/-)-Phaclofen, a GABAB receptor antagonist, increa...

journal_title：European journal of pharmacology

authors： Smolders I,De Klippel N,Sarre S,Ebinger G,Michotte Y

更新日期：1995-09-15 00:00:00

abstract：:The effect of an antisense oligonucleotide to the K+ channel coding mKv1.1 mRNA on antinociception induced by the tricyclic antidepressants, clomipramine (20-35 mg kg(-1) s.c.) and amitriptyline (10-25 mg kg(-1) s.c.), was investigated in the mouse hot-plate test. Antisense oligonucleotide (0.5-1.0-2.0-3.0 nmol per i....

journal_title：European journal of pharmacology

authors： Galeotti N,Ghelardini C,Capaccioli S,Quattrone A,Nicolin A,Bartolini A

更新日期：1997-07-02 00:00:00

abstract：:The phytochemicals, resveratrol or curcumin, have been shown to possess many pharmacological activities including anti-inflammatory, anti-oxidant, anti-microbial and anti-cancer effects. However, the underlying mechanism for their anti-tumor activity is yet to be evaluated. The present study was carried out to investi...

journal_title：European journal of pharmacology

authors： El-Azab M,Hishe H,Moustafa Y,El-Awady el-S

更新日期：2011-02-10 00:00:00

abstract：:The pharmacological properties of rat and human 5-HT3 receptors expressed in Xenopus oocytes were assessed using a two-electrode voltage clamp technique. Meta-chlorophenylbiguanide (mCPBG), a 5-HT3 receptor-selective agonist, elicited typical current responses in both rat and human 5-HT3 receptor-expressing oocytes. H...

journal_title：European journal of pharmacology

authors： Mochizuki S,Miyake A,Furuichi K

更新日期：1999-03-12 00:00:00

abstract：:K(+)-channel blocker properties have been reported for mast cell-degranulating peptide (MCD) in the central nervous system, but its action mechanism in mast cells remains unknown. We studied the effect of MCD on the membrane potential of rat peritoneal mast cells using the fluorescent probe bis-oxonol. Unexpectedly, M...

journal_title：European journal of pharmacology

authors： Mousli M,Bronner C,Bueb JL,Landry Y

更新日期：1991-07-12 00:00:00

abstract：:We have studied the ability of various uptake blockers to protect the dopamine neuronal carrier labeled with [3H]GBR 12783 (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-(propenyl)-piperazine) against N-ethylmaleimide-induced alkylation, using membrane preparations obtained from rat striatum. Pure uptake inhibitors such ...

journal_title：European journal of pharmacology

authors： Héron C,Costentin J,Bonnet JJ

更新日期：1994-11-03 00:00:00

abstract：:The neuroprotective effects of verbascoside, one of phenylpropanoid glucoside isolated from the Chinese herbal medicine Buddleja officinalis Maxim, on 1-methyl-4-phenylpyridinium ion (MPP(+)) induced apoptosis and oxidative stress in PC12 neuronal cells were investigated. Treatment of PC12 cells with MPP(+) for 48 h i...

journal_title：European journal of pharmacology

authors： Sheng GQ,Zhang JR,Pu XP,Ma J,Li CL

更新日期：2002-09-13 00:00:00

abstract：:Preeclampsia is reported in pregnant women around the world and often causes maternal/fetal mortality and morbidity. In the current study, we assessed the efficacy of celastrol on a rat preeclampsia model induced by Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME). Pregnant rats were administered L-NAME to esta...

journal_title：European journal of pharmacology

authors： Xiao S,Zhang M,He Z,Wang D

更新日期：2018-07-05 00:00:00

abstract：:The effects of inosine on sinus rate and atrial contractile force were investigated using the isolated and blood-perfused canine atrium which was perfused with arterial blood from a donor dog. Injected inosine (100-3000 micrograms) consistently induced positive chronotropic and inotropic effects. However, the larger d...

journal_title：European journal of pharmacology

authors： Furukawa Y,Chiba S

更新日期：1980-10-31 00:00:00

abstract：:In cystic fibrosis respiratory epithelial cells, the absence or dysfunction of the chloride channel CFTR (Cystic Fibrosis Transmembrane conductance Regulator) results in reduced chloride ion transport. In contrast, Ca2+-stimulated Cl- secretion is intact in cystic fibrosis airway epithelia. One possible target for dru...

journal_title：European journal of pharmacology

authors： Norez C,Vandebrouck C,Antigny F,Dannhoffer L,Blondel M,Becq F

更新日期：2008-09-11 00:00:00

abstract：:Human neuroblastoma SH-SY5Y cells express endogenous mu-opioid receptor and develop cellular tolerance to morphine after prolonged (>/=4 h) treatment with morphine. Treatment with forskolin (25 microM, 12 h), an adenylyl cyclase activator, also desensitized mu-opioid receptor response to morphine (10 microM) by 38% (P...

journal_title：European journal of pharmacology

authors： Wang Z,Sadée W

更新日期：2000-02-18 00:00:00

abstract：:The effects of veratrine and veratridine on the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) from incubations of pituitary alone, hypothalamus alone, and coincubations of hypothalamus and pituitary were examined. Veratrine produced only small increases in LH secretion from pituitaries ...

journal_title：European journal of pharmacology

authors： Powers CA,Johnson DC

更新日期：1980-08-29 00:00:00

abstract：:GABA (10-5--10-3 M) had no effect on the spontaneous outflow of previously accumulated 3H-DA or 3H-5HT from rat nigral or striatal slices. However, GABA markedly potentiated the potassium-stimulated release of 3H-DA in both brain regions, while the depolarization-induced output of 3H-5HT was only slightly increased. T...

journal_title：European journal of pharmacology

authors： Starr MS

更新日期：1978-04-01 00:00:00

abstract：:To determine the role of neurokinin A and tachykinin NK2 receptors in processing of nociceptive information at the spinal level, the selective NK2 receptor antagonist, SR 48968 (S)-N-methyl-N [4-(4-acetylamino-4-[phenyl piperidino)-2-(3,4-dichlorophenyl)-butyl] benzamide, was tested for its effects on the hyperalgesia...

journal_title：European journal of pharmacology

authors： Yashpal K,Hui-Chan CW,Henry JL

更新日期：1996-07-11 00:00:00

abstract：:The effects of an inhibitor of calmodulin, trifluoperazine (TFP), were determined on the electrical activity of cultured cell reaggregates derived from chick embryonic hearts (15-day-old). The cells exhibited naturally occurring slowly rising action potentials (APs) having a maximum rate of rise (+Vmax) of less than 3...

journal_title：European journal of pharmacology

authors： Bkaily G,Sperelakis N,Eldefrawi M

更新日期：1984-10-01 00:00:00

abstract：:The effect of idebenone on the changes in adenosine and nucleotide metabolism occurring in hippocampal slices after ischemia-like conditions (superfusion with glucose-free Krebs solution gassed with 95% N2-5% CO2) and during reperfusion with normal Krebs solution was investigated by measuring adenosine and inosine out...

journal_title：European journal of pharmacology

authors： Latini S,Pedata F,Pepeu G

更新日期：1993-11-02 00:00:00

abstract：:This study examined whether the antinociceptive activity of THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol), a GABA agonist, is mediated through an action exerted at the level of the spinal cord. Intrathecal injection of doses of THIP devoid of motor effects (1-2 micrograms) did not increase tail flick or hot pl...

journal_title：European journal of pharmacology

authors： Hammond DL,Drower EJ

更新日期：1984-08-03 00:00:00

abstract：:Vasoconstrictor responses elicited by periarterial electrical nerve stimulation were analyzed pharmacologically in the canine isolated, perfused intermediate auricular artery. Phentolamine (10 microM) significantly inhibited the vasoconstrictor responses to stimulation at 5 Hz and over but not those to stimulation at ...

journal_title：European journal of pharmacology

authors： Haniuda K,Nakane T,Chiba S

更新日期：1997-08-27 00:00:00

abstract：:Clinical evidence demonstrates altered glutamatergic neurotransmission in patients suffering from obsessive-compulsive disorder (OCD). We examined the effects of glutamate-related drugs on marble-burying behavior, which is an animal model of OCD. The uncompetitive N-methyl-d-aspartate (NMDA) antagonists memantine (10 ...

journal_title：European journal of pharmacology

authors： Egashira N,Okuno R,Harada S,Matsushita M,Mishima K,Iwasaki K,Nishimura R,Oishi R,Fujiwara M

更新日期：2008-05-31 00:00:00

abstract：:Caffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-induced locomotor stimu...

journal_title：European journal of pharmacology

authors： Marin MT,Zancheta R,Paro AH,Possi AP,Cruz FC,Planeta CS

更新日期：2011-06-25 00:00:00

abstract：:The influence of enzymatic degradation on the neurotransmitter actions of ATP was studied using the ecto-ATPase inhibitor 6-N,N-diethyl-D-beta,gamma-dibromomethyleneATP (ARL 67156). Field stimulation of the parasympathetic nerves innervating guinea-pig urinary bladder muscle strips (1-8 Hz for 20 s) produced character...

journal_title：European journal of pharmacology

authors： Westfall TD,Kennedy C,Sneddon P

更新日期：1997-06-25 00:00:00

abstract：:The spinal cord dorsal horn contains neural mechanisms which can greatly facilitate pain. It is well established that excitatory amino acids, aspartate and glutamate, are involved in the spinal transmission of nociceptive information and in the development of hyperalgesia. In the present study, intrathecal (i.t.) admi...

journal_title：European journal of pharmacology

authors： Brambilla A,Prudentino A,Grippa N,Borsini F

更新日期：1996-06-03 00:00:00

abstract：:Disturbances in oxidative metabolism are involved in many acute and chronic diseases, as well as in several other conditions. The objective of the present study was to examine the relationship between the level of intracellular reactive oxygen species in the peripheral blood granulocytes of mice, as evaluated by 2',7'...

journal_title：European journal of pharmacology

authors： Rammal H,Bouayed J,Soulimani R

更新日期：2010-02-10 00:00:00

abstract：:Several phenyl-benzazepine compounds, putatively selective dopamine D1 receptor agonists, have been used to study the effects of dopamine D1 receptor stimulation in rodents and nonhuman primates. However, the dopamine receptor selectivities of these compounds have not been established in nonhuman primates. Accordingly...

journal_title：European journal of pharmacology

authors： Weed MR,Woolverton WL,Paul IA

更新日期：1998-11-13 00:00:00

abstract：:Brefelamide is an aromatic amide isolated from Dictyostelium cellular slime molds. We found that brefelamide has a potent inhibitory growth effect measured by MTT assay in 1321N1 human astrocytoma cells. The inhibition was associated with reduced phosphorylation of extracellular signal-regulated kinase (ERK). Brefelam...

journal_title：European journal of pharmacology

authors： Honma S,Saito M,Kikuchi H,Saito Y,Oshima Y,Nakahata N,Yoshida M

更新日期：2009-08-15 00:00:00

abstract：:Kinetin has been shown to have anti-aging effects on several different systems, including plants and human cells. Recently, we demonstrated that kinetin markedly inhibited platelet aggregation in washed human platelets. In the present study, an electron spin resonance (ESR) method was used to further evaluate the scav...

journal_title：European journal of pharmacology

authors： Hsiao G,Shen MY,Lin KH,Chou CY,Tzu NH,Lin CH,Chou DS,Chen TF,Sheu JR

更新日期：2003-04-04 00:00:00

abstract：:Peptides based in the stabilised tetrapeptide HTyr-D-Ala-Gly-MePheOH have been synthesised and shown to have substantial opioid activity both in vitro and in vivo. The selectivity of these compounds of different receptor populations has been investigated using both isolated tissue assays and binding studies. Results s...

journal_title：European journal of pharmacology

authors： Handa BK,Land AC,Lord JA,Morgan BA,Rance MJ,Smith CF

更新日期：1981-04-09 00:00:00

abstract：:Previously, we showed that the synthetic nitroderivative trans-4-methyl-β-nitrostyrene (T4MeN) induced vasorelaxant effects in rat isolated aortic rings. Here, we investigated the mechanisms underlying the cardiovascular effects of T4MeN in normotensive rats. In pentobarbital-anesthetized rats, intravenous (i.v.) inje...

journal_title：European journal of pharmacology

authors： Teófilo TM,Duarte GP,Borges RS,Santos AA,Magalhães PJC,Lahlou S

更新日期：2019-04-15 00:00:00

abstract：:[3H]MDL 105,519 (((E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1[3H]-indole-2-ca rboxylic acid) is a novel radioligand which binds with high affinity, Kd = 2.5 nM, to the glycine site of adult rodent forebrain, N-methyl-D-aspartate subtype of glutamate receptors. As with other glycine site antagonists, the major det...

journal_title：European journal of pharmacology

authors： Chazot PL,Reiss C,Chopra B,Stephenson FA

更新日期：1998-07-17 00:00:00