Abstract:
:The effects of inosine on sinus rate and atrial contractile force were investigated using the isolated and blood-perfused canine atrium which was perfused with arterial blood from a donor dog. Injected inosine (100-3000 micrograms) consistently induced positive chronotropic and inotropic effects. However, the larger doses of inosine (1000 and 3000 micrograms) frequently produced slight and brief negative inotropic and chronotropic effects followed by long-lasting positive ones. Positive responses were not suppressed by treatment with propranolol. Negative responses were not inhibited by treatment with atropine. Adenosine-induced negative chronotropic and inotropic effects were potentiated by a continuous infusion of inosine at larger doses of 800-1000 micrograms/min. From these results, we concluded that inosine may have direct positive chronotropic and inotropic actions and that it potentiates adenosine-induced cardiac actions.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Furukawa Y,Chiba Sdoi
10.1016/0014-2999(80)90174-0subject
Has Abstractpub_date
1980-10-31 00:00:00pages
339-45issue
4eissn
0014-2999issn
1879-0712pii
0014-2999(80)90174-0journal_volume
67pub_type
杂志文章abstract::The sialogogic effect of SNI-2011, a novel muscarinic receptor agonist, (+/-)-cis-2-methylspilo [1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate, was compared with that of pilocarpine hydrochloride in a dose range in which the two muscarinic agonists exhibited approximately similar efficacy in eliciting ...
journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/s0014-2999(97)01338-1
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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doi:10.1016/s0014-2999(97)01101-1
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(81)90193-x
更新日期:1981-05-22 00:00:00
abstract::Substance P causes histamine release from rat peritoneal mast cells probably through direct activation of a specific G protein at micromolar concentrations. We found that peritoneal mast cells of a substrain of Wistar rats (Std:Wistar) responds to nanomolar concentrations of substance P by releasing histamine in a con...
journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/s0014-2999(99)00338-6
更新日期:1999-06-18 00:00:00
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章,评审
doi:10.1016/s0014-2999(99)00361-1
更新日期:1999-06-30 00:00:00
abstract::Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum. The study investigated the effects and mechanisms of aloe-emodin-induced cell death in human lung squamous cell carcinoma cell line CH27. Aloe-emodin (40 microM)-induced CH27 cell apoptosis w...
journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/s0014-2999(01)01467-4
更新日期:2001-11-23 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/j.ejphar.2019.01.005
更新日期:2019-03-05 00:00:00
abstract::Injection into the superior colliculus of anaesthetised rats of the nitric oxide (NO) synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 1 micromol), but not its inactive enantiomer N(omega)-nitro-D-arginine methyl ester (D-NAME; 1 micromol), significantly (P < 0.01) increased the mean arterial blood p...
journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/s0014-2999(97)83029-4
更新日期:1997-06-05 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(88)90094-5
更新日期:1988-09-13 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/s0014-2999(01)01199-2
更新日期:2001-08-24 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/s0014-2999(98)00281-7
更新日期:1998-06-12 00:00:00
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journal_title:European journal of pharmacology
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doi:10.1016/j.ejphar.2005.08.035
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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更新日期:2015-07-05 00:00:00
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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更新日期:2018-02-05 00:00:00
abstract::The involvement of peptidoleukotrienes (LTs) in mediating the increase in microvascular permeability associated with experimental cutaneous immediate hypersensitivity was studied by examining the effect of SK&F 104353, a potent and selective LT-antagonist, on the response evoked by graded, intradermal injections of an...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
pub_type: 杂志文章
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journal_title:European journal of pharmacology
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更新日期:2020-08-05 00:00:00
abstract::The integrity of endothelial cell monolayers, a critical requirement for barrier maintenance, is needed for the prevention of edema formation. To investigate the mechanisms by which 2-phenyl-4-quinolone (YT-1) provided protection against serotonin-induced exudation, rat heart endothelial cell cultures were used. In th...
journal_title:European journal of pharmacology
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更新日期:1997-09-24 00:00:00