Long-term interactions between endogenous and exogenous opiates.

abstract：:Fabry disease (FD) is an X-linked metabolic storage disorder arising from the deficiency of lysosomal α-galactosidase A, which leads to the gradual accumulation of glycosphingolipids, mainly globotriaosylceramide (Gb3), throughout the body. Pain in the extremities is an early symptom of FD; however, the underlying pat...

journal_title：European journal of pharmacology

authors： Sugimoto J,Satoyoshi H,Takahata K,Muraoka S

更新日期：2021-01-20 00:00:00

abstract：:In the isolated perfused guinea-pig heart low-pH buffer (pH 5), lactic acid (5 mM), capsaicin (10(-7) M) and nicotine (10(-4) M) all evoked a clear-cut release of calcitonin gene-related peptide (CGRP) from sensory nerves. Incubation with the proposed capsaicin receptor antagonist, capsazepine (10(-5) M), significantl...

journal_title：European journal of pharmacology

authors： Franco-Cereceda A,Lundberg JM

更新日期：1992-10-06 00:00:00

abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was incidentally administered to pregnant marmosets during the whole gestational period, except for the last 15 days before term. The infant monkeys were killed 5 months after birth, and dopamine and its metabolites were measured in the striatum and the nucleus accum...

journal_title：European journal of pharmacology

authors： Pérez-Otaño I,Oset C,Trinidad Herrero M,Luquin MR,Kupsch A,Oertel W,Obeso JA,Del Río J

更新日期：1992-07-07 00:00:00

abstract：:We have developed a model of ischaemia-reperfusion injury in C57BL/6 mice involving ischaemia for 0.5 to 2.5 h with an elastic tourniquet on one hind limb and reperfusion for 24 h, analogous to a well-established model of ischaemia-reperfusion injury in the rat. Viability was assessed in tissue homogenates of the gast...

journal_title：European journal of pharmacology

authors： Knight KR,Zhang B,Morrison WA,Stewart AG

更新日期：1997-08-13 00:00:00

abstract：:The aim of this study was to investigate the contribution of the Na(+)/H(+) exchanger to cerebral ischemia using SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate), a newly synthesized compound. In in vitro experiments, we evaluated the inhibitory effect of SM-20220 on the Na(+)/H(+) exc...

journal_title：European journal of pharmacology

authors： Kuribayashi Y,Itoh N,Kitano M,Ohashi N

更新日期：1999-10-27 00:00:00

abstract：:Sabiporide, a new benzoguanidine, was characterized on fibroblasts stably expressing the Na(+)/H(+) exchanger isoforms NHE-1, NHE-2 and NHE-3. 22Na(+) uptake experiments show that this compound possesses a K(i) of 5+/-1.2 x 10(-8) M for NHE-1, and discriminates efficiently between the NHE-1, -2 and -3 isoforms (K(i) f...

journal_title：European journal of pharmacology

authors： Touret N,Tanneur V,Godart H,Seidler R,Taki N,Bürger E,Dämmgen J,Counillon L

更新日期：2003-01-17 00:00:00

abstract：:The effects of systemic administration of the full dopamine D1 receptor agonist A-77636 on acetylcholine release in rat frontal cortex and hippocampus were studied using in vivo microdialysis. Administration of A-77636 (4 mumol/kg s.c.) greatly (> 230%) increased both cortical and hippocampal acetylcholine release for...

journal_title：European journal of pharmacology

authors： Acquas E,Day JC,Fibiger HC

更新日期：1994-07-21 00:00:00

abstract：:The present experiments determined the effects of selective dopamine receptor antagonists on the initiation and expression of sensitization to the locomotor-stimulating effects of morphine in rats. Although both the dopamine D1 receptor antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benza...

journal_title：European journal of pharmacology

authors： Jeziorski M,White FJ

更新日期：1995-03-14 00:00:00

abstract：UNLABELLED:The influence of different nonsteroidal anti-inflammatory drugs (NSAIDs) and of a proton pump inhibitor on the healing parameters of a chronic gastric ulcer was evaluated. Wistar rats were used after the induction of a chronic acetic acid ulcer. The animals were treated orally for 8 and 15 days, twice daily,...

journal_title：European journal of pharmacology

authors： Berenguer B,Alarcón de la Lastra C,Moreno FJ,Martín MJ

更新日期：2002-05-03 00:00:00

abstract：:The aim of the study was to reveal general characteristics of the ligand-receptor interaction in the binding and displacement of radiolabeled ligands. The binding and displacement of DL-[3H]propranolol hydrochloride ([3H]propranolol) and L-[propyl-2,3, -3H]dihydroalprenolol ([3H]dihydroalprenolol), beta-adrenoceptor a...

journal_title：European journal of pharmacology

authors： Manukhin BN,Nesterova LA,Smurova EA,Kichikulova TP

更新日期：1999-12-15 00:00:00

abstract：:Phencyclidine and its derivatives bind specifically and reversibly to rat brain and peripheral organs. Binding characteristics are different in brain, lung, kidney, heart and liver. Affinities of phencyclidines for the brain receptor but not those for peripheral organs are correlated with the pharmacological activitie...

journal_title：European journal of pharmacology

authors： Vincent JP,Vignon J,Kartalovski B,Lazdunski M

更新日期：1980-11-07 00:00:00

abstract：:Cabergoline 1-[(6-allylergolin-8 beta-yl)carbonyl]-1-[3-(dimethylamino) propyl]-3-ethylurea is a recently developed ergot derivative with a long-lasting dopamine agonist action. We now studied the ability of cabergoline to counteract the development of a prolactin-secreting tumor (prolactinoma) induced in female rats ...

journal_title：European journal of pharmacology

authors： Dall'Ara A,Lima L,Cocchi D,Di Salle E,Cancio E,Devesa J,Müller EE

更新日期：1988-06-22 00:00:00

abstract：:The significance of the blood pressure elevation caused by N(G)-nitro-L-arginine (L-NNA) to inhibitory mechanism of the drug on depressor responses to acetylcholine in anesthetized dogs was investigated. L-NNA (50 mg kg(-1), i.v.) elevated blood pressure to a plateau of 30-50 mm Hg above baseline level and shifted the...

journal_title：European journal of pharmacology

authors： Nakahara T,Nejishima H,Nakayama K,Ishii K

更新日期：1999-06-04 00:00:00

abstract：:CPP, administered systemically, elicited four distinct responses characteristic of serotonin-receptor activation in the central nervous system. The crossed extensor reflex in the acutely spinalized rat was enhanced by treatment with CPP, 1-16 mg/kg. CPP, 1.11-10 mg/kg, elicited a dose-related increase in head twitches...

journal_title：European journal of pharmacology

authors： Clineschmidt BV,Mcguffin JC,Pflueger AB

更新日期：1977-07-01 00:00:00

abstract：:Schizophrenia is a serious psychiatric disorder that is most frequently treated with the administration of antipsychotics. Although onset of schizophrenia typically occurs in late adolescence, the majority of preclinical research on the behavioral effects of antipsychotics and their mechanism(s) of action has been con...

journal_title：European journal of pharmacology

authors： Wiley JL

更新日期：2008-01-14 00:00:00

abstract：:Right ventricular kitten papillary muscles were incubated with dibutyryl adenosine 3',5'-monophosphate (dbcAMP) at varying concentrations as low as 1 X 10(-4)M. A positive inotropic effect was observed with all concentrations of dbcAMP. Concomitant administration of 5 X 10(-4)M monobutyryl guanosine 3',5'-monophosphat...

journal_title：European journal of pharmacology

authors： Wilkerson RD,Paddock RJ,George WJ

更新日期：1976-03-01 00:00:00

abstract：:We studied the interaction of S-methylisothiourea (a selective inducible nitric oxide synthase inhibitor) with rofecoxib (a selective cyclooxygenase-2 inhibitor) and mefenamic acid (a non-selective cyclooxygenase inhibitor) in adjuvant-induced arthritis in female albino Wistar rats, applying the isobolographic analysi...

journal_title：European journal of pharmacology

authors： Bhat AS,Tandan SK,Kumar D,Krishna V,Prakash VR

更新日期：2007-02-05 00:00:00

abstract：:The inhibitory effect of cytochalasin B on contraction of smooth muscle cells isolated from guinea-pig taenia coli was investigated. Cytochalasin B (10-70 microM) inhibited the high K+ (70 mM)-induced contraction in a dose-dependent manner, and the maximum and the half-maximum effects were obtained at 50 and 15 microM...

journal_title：European journal of pharmacology

authors： Obara K,Yabu H

更新日期：1994-04-01 00:00:00

abstract：:Preclinical data, performed in a limited number of pain models, suggest that functional blockade of metabotropic glutamate (mGlu) receptors may be beneficial for pain management. In the present study, effects of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective mGlu5 receptor antagonist, were examined in...

journal_title：European journal of pharmacology

authors： Zhu CZ,Wilson SG,Mikusa JP,Wismer CT,Gauvin DM,Lynch JJ 3rd,Wade CL,Decker MW,Honore P

更新日期：2004-12-15 00:00:00

abstract：:Delta9-tetrahydrocannabinol induces [Ca2+]i increases in DDT1MF-2 smooth muscle cells. Both Ca2+ entry and release from intracellular Ca2+ stores were concentration dependently activated. The Ca2+ entry component contributed most to the increases in [Ca2+]i. Stimulation with delta9-tetrahydrocannabinol after functiona...

journal_title：European journal of pharmacology

authors： Filipeanu CM,de Zeeuw D,Nelemans SA

更新日期：1997-10-01 00:00:00

abstract：:Intracellular accumulation of calcium is thought to play an integral role in the progression of ischemic injury and cell death. We infused the calcium entry blocker, nitrendipine (1.5 micrograms/kg per min), into cats in order to investigate the importance of extracellular Ca2+ influx during hemorrhagic shock. Nitrend...

journal_title：European journal of pharmacology

authors： Hock CE,Su JY,Lefer AM

更新日期：1984-01-13 00:00:00

abstract：:This study shows that in spontaneously hypertensive rats (SHR) of 14-weeks-old, the sympathetically-induced, but not noradrenaline-induced tachycardic response are higher than age-matched Wistar normotensive rats. Furthermore, in SHR the sympathetically-induced tachycardic response was: (1) unaffected by moxonidine (3...

journal_title：European journal of pharmacology

authors： Cobos-Puc LE,Sánchez-López A,Centurión D

更新日期：2016-11-15 00:00:00

abstract：:Thaliporphine (0.1-100 microM) produced sustained, concentration-dependent contraction in isolated rings of rat aorta. Thaliporphine (ED50 = 1.5 +/- 0.5 microM) was less potent than endothelin (ED50 = 3.9 +/- 0.4 nM), but was more potent than Bay K 8644 (ED50 = 5.5 +/- 0.6 microM). Thaliporphine also contracted guinea...

journal_title：European journal of pharmacology

authors： Teng CM,Yu SM,Lee SS,Ko FN,Su MJ,Huang TF

更新日期：1993-03-16 00:00:00

abstract：:The effects of intracerebral microinjections of neurotensin and xenopsin on self-stimulation of the medial prefrontal cortex of the rat were studied. Unilateral microinjections into the medial prefrontal cortex of neurotensin at doses of 0.625, 1.25, 2.5, 5 and 10 nmol produced a dose-related decrease of self-stimulat...

journal_title：European journal of pharmacology

authors： Ferrer JM,Sabater R,Saez JA

更新日期：1993-01-26 00:00:00

abstract：:Ten beta-adrenoceptor blocking drugs varying in lipophilicity and beta-adrenoceptor blocking potency were examined for inhibitory effects on synaptosomal [3H]noradrenaline uptake. All compounds produced a concentration-dependent inhibition of noradrenaline uptake, but were at least one order of magnitude less potent t...

journal_title：European journal of pharmacology

authors： Street JA,Walsh A

更新日期：1984-07-13 00:00:00

abstract：:The binding of tritium-labelled BIBP3226, N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine amide, to human neuroblastoma SK-N-MC cells was investigated. [3H]BIBP3226 reversibly binds to neuropeptide Y receptors of the Y1 subtype expressed in SK-N-MC cells with a KD of 2.1 +/- 0.3 nM (mean +/- S.E.M., n = 3)...

journal_title：European journal of pharmacology

authors： Entzeroth M,Braunger H,Eberlein W,Engel W,Rudolf K,Wienen W,Wieland HA,Willim KD,Doods HN

更新日期：1995-05-24 00:00:00

abstract：:The effect of i.v. morphine on the spinal nociceptive flexor reflex was examined in decerebrate, unanesthetized rats in which the spinal cord was acutely or chronically transected. In acutely spinalized rats i.v. morphine dose dependently depressed the flexor reflex with an ED50 of 1.4 mg/kg. In rats in which the spin...

journal_title：European journal of pharmacology

authors： Hao JX,Wiesenfeld-Hallin Z,Xu XJ

更新日期：1990-12-04 00:00:00

abstract：:(5R,6R)-6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[ 3.2.1]octane (PTAC) is a selective muscarinic receptor ligand. The compound exhibits high affinity for central muscarinic receptors with partial agonist mode of action at muscarinic M(2) and M(4) and antagonist mode of action at muscarinic M(1), M(3) and M(5...

journal_title：European journal of pharmacology

authors： Rasmussen T,Sauerberg P,Nielsen EB,Swedberg MD,Thomsen C,Sheardown MJ,Jeppesen L,Calligaro DO,DeLapp NW,Whitesitt C,Ward JS,Shannon HE,Bymaster FP,Fink-Jensen A

更新日期：2000-08-25 00:00:00

abstract：:The effect of some tryptaminergic drugs on electroshock fighting behaviour in rats was determined. Reserpine and tetrabenazine reduced the fighting responses while 5-hydroxytryptophan increased the fighting responses in normal as well as reserpine-treated animals. p-Chlorophenylalanine, a specific depletor of brain se...

journal_title：European journal of pharmacology

authors： Anand M,Gupta GP,Bhargava KP

更新日期：1976-10-01 00:00:00

abstract：:Osteoporosis is a high mortality and morbidity ranged skeletal disease and results in high costs of medical care in the European Union. We evaluated the possible protective effect of alpha-lipoic acid (ALA) on rat bone metabolism in ovariectomy and inflammation-mediated osteoporosis models. Groups were designed as: (1...

journal_title：European journal of pharmacology

authors： Polat B,Halici Z,Cadirci E,Albayrak A,Karakus E,Bayir Y,Bilen H,Sahin A,Yuksel TN

更新日期：2013-10-15 00:00:00