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Delta9-tetrahydrocannabinol activates [Ca2+]i increases partly sensitive to capacitative store refilling.

Abstract：

:Delta9-tetrahydrocannabinol induces [Ca2+]i increases in DDT1MF-2 smooth muscle cells. Both Ca2+ entry and release from intracellular Ca2+ stores were concentration dependently activated. The Ca2+ entry component contributed most to the increases in [Ca2+]i. Stimulation with delta9-tetrahydrocannabinol after functional downregulation of intracellular Ca2+ stores by longterm thapsigargin treatment, still induced a major Ca2+ entry and a minor Ca2+ release component. Thapsigargin sensitive influx and release were selectively inhibited by the cannabinoid CB1 receptor antagonist SR141716A. No effects on [Ca2+]i were obtained after stimulation with the CB2 receptor agonist palmitoylethanolamide. This study is the first demonstration of (1) Ca2+ release from thapsigargin sensitive intracellular stores and capacitative Ca2+ entry via CB1 receptor stimulation and of (2) an additional delta9-tetrahydrocannabinol induced thapsigargin insensitive component, mainly representing Ca2+ influx which is neither mediated by CB1 nor CB2 receptor stimulation.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Filipeanu CM,de Zeeuw D,Nelemans SA

doi

10.1016/s0014-2999(97)01254-5

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

R1-3

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(97)01254-5

journal_volume

336

pub_type

杂志文章

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