Interaction of histamine H2-receptor antagonists with GABA and benzodiazepine binding sites in the CNS.

abstract：:Cholangiocarcinoma (CCA) is one of the most serious of all cancers and a major public health problem. CCA is an extremely invasive cancer, and the survival rate for CCA patients is only 24 months after diagnosis. Although surgery and chemotherapy can extend the survival rate to 5 years, < 20-40% of CCA patients will s...

journal_title：European journal of pharmacology

authors： Lee MY,Li YZ,Huang KJ,Huang HC,Lin CY,Lee YR

更新日期：2018-11-15 00:00:00

abstract：:The effect of chronic treatment (21 days s.c.) with SCH 23390 and haloperidol on spontaneously active DA neurones in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) was studied in rats by means of single unit recording techniques. The specific DA D-1 receptor antagonist SCH 23390 was injected twi...

journal_title：European journal of pharmacology

authors： Skarsfeldt T

更新日期：1988-01-12 00:00:00

abstract：:CysLT1 receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT2 receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs and use this mod...

journal_title：European journal of pharmacology

authors： Sekioka T,Kadode M,Yonetomi Y,Kamiya A,Fujita M,Nabe T,Kawabata K

更新日期：2017-01-05 00:00:00

abstract：:Pulmonary vascular responses to 5,7-dimethyl-2-ethyl-3-[[2'-[butyloxycarbonyl)amino-sulfonyl]-5'-(3-meth oxybenzyl)-[1,1'-biphenyl]-4-yl]methyl]-3H-imidazo[4,5-b]pyridine (L-163,491), a novel nonpeptide angiotensin agonist, and angiotensin IV, the 3-8 amino acid fragment of angiotensin, were compared with responses to...

journal_title：European journal of pharmacology

authors： Kaye AD,Nossaman BD,Kivlighn S,Ibrahim IN,De Witt BJ,Kadowitz PJ

更新日期：1995-12-12 00:00:00

abstract：:Several recent reports have demonstrated a role for selective cannabinoid CB2 receptor agonists in pain modulation, showing both analgesic and antihyperalgesic activities. While the mechanism of action is poorly understood, it has been postulated that these effects may be indirect, involving release of endogenous opio...

journal_title：European journal of pharmacology

authors： Whiteside GT,Gottshall SL,Boulet JM,Chaffer SM,Harrison JE,Pearson MS,Turchin PI,Mark L,Garrison AE,Valenzano KJ

更新日期：2005-12-28 00:00:00

abstract：:We examined the effects of mammalian tachykinins on human bronchial secretion in vitro using fucose as an endogenous marker for mucus. Substance P (SP, 10(-9)-10(-5) M) increased secretion in a dose-related manner and was more potent than neurokinin A or neurokinin B. The enkephalinase (endopeptidase 24.11) inhibitor ...

journal_title：European journal of pharmacology

authors： Rogers DF,Aursudkij B,Barnes PJ

更新日期：1989-12-19 00:00:00

abstract：:Excessive intracellular accumulation of zinc (Zn(2+)) is neurotoxic and contributes to a number of neuropathological conditions. Here, we investigated the protective effect of 3-morpholinosydnonimine (SIN-1) against Zn(2+)-induced neuronal cell death in differentiated PC12 cells. We found that Zn(2+)-induced PC12 cell...

journal_title：European journal of pharmacology

authors： An JM,Moon SA,Hong SY,Kang JW,Seo JT

更新日期：2015-02-05 00:00:00

abstract：:Oxyntomodulin is a hormone and a growth factor. It activates two receptors, the Glucagon-like peptide 1 (GLP-1) and the glucagon receptor. GLP-1 mimetics are on the market as treatments for type 2 diabetes and are well tolerated. These drugs have shown neuroprotective properties in animal models of neurodegenerative d...

journal_title：European journal of pharmacology

authors： Liu W,Li Y,Jalewa J,Saunders-Wood T,Li L,Hölscher C

更新日期：2015-10-15 00:00:00

abstract：:The effects of nicotine, carbachol, hexamethonium and scopolamine were investigated on distress vocalizations (DBs) of acutely isolated domestic chicks. Nicotine attenuated, while the antimuscarinic scopolamine increased the frequency of separation-induced DVs. Furthermore, the stress attenuating effects of nicotine w...

journal_title：European journal of pharmacology

authors： Sahley TL,Panksepp J,Zolovick AJ

更新日期：1981-06-19 00:00:00

abstract：:Angiotensin II increased the inositol phosphates production (EC50 = 3.4+/-0.7 nM) in Chinese hamster ovary (CHO) cells expressing the cloned human angiotensin AT1 receptor (CHO-AT1 cells). Coincubation with angiotensin AT1 receptor antagonists produced parallel rightward shifts of the concentration-response curve with...

journal_title：European journal of pharmacology

authors： Fierens FL,Vanderheyden PM,De Backer JP,Vauquelin G

更新日期：1999-05-14 00:00:00

abstract：:Several selective phosphodiesterase 4 inhibitors were found to be potent inhibitors of the N-formyl-Met-Leu-Phe (fMLP)-induced leukotriene B4 biosynthesis by human polymorphonuclear leukocytes with IC50s in the nanomolar range (0.09-26 nM). The rank order of potency was 6-(4-pyridylmethyl)-8-(3-nitrophenyl)quinoline (...

journal_title：European journal of pharmacology

authors： Denis D,Riendeau D

更新日期：1999-02-19 00:00:00

abstract：:We used male Wistar rats to determine the effects of lipopolysaccharide (LPS) on gastric secretion. After pylorus ligation, 24-h fasted rats received i.p. injections of different doses of LPS dissolved in sterile saline. The amounts of gastric acid and pepsin secreted were determined 2, 4 or 8 h after injection. Small...

journal_title：European journal of pharmacology

authors： Uehara A,Okumura T,Okamura K,Takasugi Y,Namiki M

更新日期：1990-05-31 00:00:00

abstract：:Two clinically effective anticonvulsants, phenobarbitone and diazepam, protected 5-day old chicks against picrotoxin convulsions without reducing brain GABA-transaminase activity or raising brain GABA concentration. Ethanolamine-O-sulphate and amino-oxyacetic acid, in doses which inhibited GABA-transminase by at least...

journal_title：European journal of pharmacology

authors： Horton RW,Meldrum BS,Sawaya MC,Stephenson JD

更新日期：1976-11-01 00:00:00

abstract：:A number of neurosteroids exert antiseizure and/or neuroprotective properties. The aim of this study was to evaluate the effect of the neurosteroid alphaxalone on the protective action of conventional antiepileptics in four seizure tests. Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-...

journal_title：European journal of pharmacology

authors： Borowicz KK,Zadrozniak M,Swiader M,Kowalska A,Kleinrok Z,Czuczwar SJ

更新日期：2002-08-02 00:00:00

abstract：:Many studies have demonstrated that cyclophosphamide (CPA) can affect hepatic cytochrome p450 (CYP) isoenzyme activity in animals. We have investigated the effect of CPA on gene expression of various CYP enzymes as well as beta-actin in the human acute promyelocytic leukemia cell line (HL-60S) and its multidrug-resist...

journal_title：European journal of pharmacology

authors： Xie HJ,Lundgren S,Broberg U,Finnström N,Rane A,Hassan M

更新日期：2002-08-09 00:00:00

abstract：:The choleretic action of 3-(2,4,5-triethoxybenzoyl)propionic acid (AA-149) was studied in anesthetized dogs. AA-149 produced a dose-dependent increase of the bile flow with both i.v. and intrajejunal administration of doses 1 mg/kg and higher. Biliary clearance of 14C-erythritol showed that AA-149 stimulated canalicul...

journal_title：European journal of pharmacology

authors： Satoh H,Kanno M,Maki Y

更新日期：1978-03-01 00:00:00

abstract：:The aims of the present study were to establish whether vasoactive intestinal polypeptide (VIP) could mobilize internally-stored Ca2+ and whether Ca2+ release could trigger Ca2+ influx from the extracellular space. Bovine pulmonary artery endothelial cells from an established cell line were loaded with fura-2/AM and c...

journal_title：European journal of pharmacology

authors： Low AM,Sormaz L,Kwan CY,Daniel EE

更新日期：1997-11-27 00:00:00

abstract：:In anesthetized, artificially ventilated guinea pigs immunized against ovalbumin, challenge with aerosolized ovalbumin (0.1 mg) elicited a substantial and sustained increase of insufflation pressure. The inhibitor of endogenous nitric oxide (NO) synthesis, L-NAME (N omega-nitro-L-arginine methylester, 30 mg kg-1 i.v.)...

journal_title：European journal of pharmacology

authors： Persson MG,Friberg SG,Hedqvist P,Gustafsson LE

更新日期：1993-11-16 00:00:00

abstract：:18-Methoxycoronaridine, a novel iboga alkaloid congener that decreases drug self-administration in several animal models, may be a potential treatment for multiple forms of drug abuse. In previous work, 18-methoxycoronaridine was found to be a somewhat selective antagonist at alpha3beta4 nicotinic receptors; and low d...

journal_title：European journal of pharmacology

authors： Glick SD,Maisonneuve IM,Kitchen BA

更新日期：2002-07-19 00:00:00

abstract：:The pressor effect of 4-aminopyridine (4-AP) was studied in anesthetized cats and in isolated cat aortic ring preparations. A significant increase in blood pressure (38.9 +/- 11.4 mmHg) was observed following intravenous administration of 4-AP (0.3 mg/kg). The elevated blood pressure lasted for 1.3 h and returned to t...

journal_title：European journal of pharmacology

authors： Yen MH,Lee SH,Ho ST

更新日期：1985-07-11 00:00:00

abstract：:We investigated the effects of intraperitoneal administration of adrenoceptor antagonists to the hyperthermia and hyperglycemia induced by prostaglandin F2 alpha (50 micrograms) injected into the third cerebral ventricle in anesthetized rats. Phentolamine inhibited the hyperthermia and hyperglycemia induced by prostag...

journal_title：European journal of pharmacology

authors： Nonogaki K,Iguchi A,Sakamoto N

更新日期：1994-09-01 00:00:00

abstract：:The anticonvulsant compound oxcarbazepine and its principal 10-monohydroxy metabolite protected potently against electroshock-induced tonic hindlimb extension. Maximal plasma concentrations depended on dose and were reached < or = 1 h after an oral dose of oxcarbazepine and < 2 h after monohydroxy derivative. In mice,...

journal_title：European journal of pharmacology

authors： Wamil AW,Schmutz M,Portet C,Feldmann KF,McLean MJ

更新日期：1994-12-27 00:00:00

abstract：:We investigated the effects of three bile acids conjugated with N-acetylglucosamine, ursodeoxycholate N-acetylglucosaminide, tauroursodeoxycholate N-acetylglucosaminide and glycoursodeoxycholate N-acetylglucosaminide, on bile flow and biliary excretion of various markers in comparison with ursodeoxycholic acid, taurou...

journal_title：European journal of pharmacology

authors： Iwaki T,Hirabayashi N,Miyazawa N,Takeuchi Y,Ishizaki K,Sakakura H,Kasai H,Maeda M,Araki T

更新日期：1998-12-11 00:00:00

abstract：:In the guinea-pig myenteric plexus-longitudinal muscle preparation from the small intestine, the release of acetylcholine evoked by substance P and vasoactive intestinal polypeptide was examined in vitro. Both neuropeptides stimulated efflux of [3H]acetylcholine from myenteric neurons in a calcium-dependent manner. Th...

journal_title：European journal of pharmacology

authors： Yau WM,Dorsett JA,Youther ML

更新日期：1986-01-21 00:00:00

abstract：:The effect of the kappa-opioid receptor agonist, bremazocine, on plasma oxytocin levels in rats was measured by a sensitive radioimmunoassay. Initially, a decrease in plasma oxytocin levels was seen 30 min after injection. This was in accordance with the bremazocine inhibition of oxytocin release after submaximal elec...

journal_title：European journal of pharmacology

authors： Grell S,Fjalland B,Christensen JD

更新日期：1989-07-04 00:00:00

abstract：:The effect of omega-conotoxin on opiate analgesia and withdrawal syndrome was investigated in rats. omega-Conotoxin given i.c.v. and i.p. caused weak analgesia in the tail-flick test. When the toxin (20 ng/rat) was given i.c.v. immediately before morphine (1.5 micrograms/rat i.c.v.) the resultant analgesic effect was ...

journal_title：European journal of pharmacology

authors： Basilico L,Parolaro D,Rubino T,Gori E,Giagnoni G

更新日期：1992-07-21 00:00:00

abstract：:The effects of the alpha-agonists clonidine and guanfacine on rat cortical norepinephrine turnover during morphine withdrawal were assessed. Cortical norepinephrine levels were measured, after administration of alpha-methyl-p-tyrosine, by fluorometric assay. Chronic treatment with morphine did not affect norepinephrin...

journal_title：European journal of pharmacology

authors： Zigun JR,Bannon MJ,Roth RH

更新日期：1981-04-09 00:00:00

abstract：:Galloyl group-containing catechins, such as epigallocatechin-3 gallate, inhibit receptor tyrosine kinase activity of several growth factor receptors. This study investigated the effects of epigallocatechin-3 gallate, as compared to epicatechin, on vascular endothelial growth factor-induced intracellular signaling and ...

journal_title：European journal of pharmacology

authors： Neuhaus T,Pabst S,Stier S,Weber AA,Schrör K,Sachinidis A,Vetter H,Ko YD

更新日期：2004-01-12 00:00:00

abstract：:The persistence of neurogenesis raises the idea that neurons produced by the resident or transplanted neural stem cells could replace the neurons lost from brain injury or neurodegenerative disease. Therefore, compounds or methods for promoting neuronal differentiation become the focus of neurodegenerative disease the...

journal_title：European journal of pharmacology

authors： Huang JY,Ma YZ,Yuan YH,Zuo W,Chu SF,Liu H,Du GH,Zhang DM,Chen NH

更新日期：2016-09-05 00:00:00

abstract：:The purpose of our study was to examine whether a significant interaction occurs between NMDA and non-NMDA receptor antagonists on respiratory function. For this purpose chloralose-anesthetized cats were used and respiratory minute volume (VE), tidal volume (Vt) respiratory rate (f), inspiratory and expiratory duratio...

journal_title：European journal of pharmacology

authors： McManigle JE,Taveira DaSilva AM,Dretchen KL,Gillis RA

更新日期：1994-01-24 00:00:00