Calcium-dependent stimulation of acetylcholine release by substance P and vasoactive intestinal polypeptide.

abstract：:The antithrombotic effect of desethyl KBT-3022, which is the main active metabolite of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl] pyrrol-1-ylacetate; a cyclooxygenase inhibitor), was determined using a photochemically induced arterial thrombosis model in the rat femoral artery...

journal_title：European journal of pharmacology

authors： Shimazawa M,Takiguchi Y,Umemura K,Kondo K,Nakashima M

更新日期：1997-06-11 00:00:00

abstract：:The stimulation of spinal cannabinoid type 2 (CB(2)) receptors is a suitable strategy for the alleviation of experimental pain symptoms. Several reports have described the up-regulation of spinal cannabinoid CB(2) receptors in neuropathic settings together with the analgesic effects derived from their activation. Besi...

journal_title：European journal of pharmacology

authors： Curto-Reyes V,Boto T,Hidalgo A,Menéndez L,Baamonde A

更新日期：2011-10-01 00:00:00

abstract：:The alpha1-adrenoceptor subtypes of rat prostate were characterized in binding and functional experiments. In binding experiments, [3H]tamsulosin bound to a single class of binding sites with an affinity (pKD) of 10.79+/-0.04 and Bmax of 87+/-2 fmol mg(-1) protein. This binding was inhibited by prazosin, 2-(2,6-dimeth...

journal_title：European journal of pharmacology

authors： Hiraoka Y,Ohmura T,Oshita M,Watanabe Y,Morikawa K,Nagata O,Kato H,Taniguchi T,Muramatsu I

更新日期：1999-01-29 00:00:00

abstract：:Oxidative stress and inflammation play key roles in the pathogenesis of Multiple sclerosis (MS). Different drugs have been used in the clinical practice, however, there is not a completely effective treatment. Due to its potential therapeutic action, medical ozone represents a promising approach for neurodegenerative ...

journal_title：European journal of pharmacology

authors： Delgado-Roche L,Riera-Romo M,Mesta F,Hernández-Matos Y,Barrios JM,Martínez-Sánchez G,Al-Dalaien SM

更新日期：2017-09-15 00:00:00

abstract：:Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect, whereas eNOS-derived N...

journal_title：European journal of pharmacology

authors： Atef Y,El-Fayoumi HM,Abdel-Mottaleb Y,Mahmoud MF

更新日期：2017-11-15 00:00:00

abstract：:Endogenous hydrogen sulfide is produced by cystathionine-γ-lyase and cystathionine-β-synthase in a variety of tissues and has recently been implicated in the regulation of cardiac functions. Acceleration of the heart rate in response to catecholamines is impaired in patients with cirrhosis. The present study was aimed...

journal_title：European journal of pharmacology

authors： Babaei-Karamshahlou M,Hooshmand B,Hajizadeh S,Mani AR

更新日期：2012-12-05 00:00:00

abstract：:Mizoribine is a disease-modifying anti-rheumatic drug (DMARD) that is used in the treatment of rheumatoid arthritis. However, clinical use of the drug is restricted to a few Asian countries due to a lack of comprehensive evidence on its effectiveness. The inhibitory effect of the drug on human osteoclastogenesis was i...

journal_title：European journal of pharmacology

authors： Lee YA,Yang HI,Park EK,Bang JS,Choi HM,Oh DH,Lee SH,Hong SJ,Jo YJ,Yoo MC,Kim KS

更新日期：2009-03-01 00:00:00

abstract：:Substance P (SP) caused an immediate and vigorous contraction of the longitudinal smooth muscle layer of the guinea-pig ileum. The contractile response to SP, unlike that to acetylcholine or histamine was not maintained but faded to baseline levels in about 6 min. When 0.3-1.0 nM SP was added the fading time was short...

journal_title：European journal of pharmacology

authors： Huidobro-Toro JP,Chelala CA,Bahouth S,Nodar R,Musacchio JM

更新日期：1982-06-16 00:00:00

abstract：:Repeated morphine treatments result in sensitization, an increase in the efficacy of morphine to stimulate locomotor activity. study examined the effects of increasing serotonin (5-hydroxytryptamine, 5-HT) transmission on morphine-sensitization. For five days rats were administered saline or 5.0 mg/kg fluoxetine prior...

journal_title：European journal of pharmacology

authors： Sills TL,Fletcher PJ

更新日期：1997-10-22 00:00:00

abstract：:Schedule-induced polydipsia occurs when food-deprived rats are exposed to a fixed-interval feeding schedule (FI = 60 s) for 1 h every day. Amperozide, a novel antipsychotic drug with a strong affinity for the 5-HT2 receptor, was injected i.p. after completion of the requisite training sessions. The experimental ration...

journal_title：European journal of pharmacology

authors： Tung CS,Wu WH,Tseng CJ,Yin TH

更新日期：1994-04-21 00:00:00

abstract：:We previously reported that intracerebroventricularly (i.c.v.) administered (±)-epibatidine (a potent agonist of nicotinic acetylcholine receptors) (1, 5 and 10 nmol/animal) dose-dependently elevated plasma levels of noradrenaline and adrenaline and that this response was reduced by i.c.v. administered indomethacin (c...

journal_title：European journal of pharmacology

authors： Shimizu T,Tanaka K,Nakamura K,Taniuchi K,Yokotani K

更新日期：2012-09-15 00:00:00

abstract：:Acute myeloid leukemia (AML) arises from neoplastic transformation of hematopoietic stem and progenitor cells, and resistance to conventional chemotherapy remains one of the greatest challenges in treating the disease. Extensive data have demonstrated that angiogenesis is associated with AML progression and chemothera...

journal_title：European journal of pharmacology

authors： Deng M,Zhao H,Chen Q,Zhao J,Shi Y,Yu L,Fang Z,Xu B

更新日期：2019-06-15 00:00:00

abstract：:The characteristics of [3H](+)-pentazocine and [3H]1,3-di(2-tolyl) guanidine (DTG) binding to mouse whole brain, cortex, cerebellum and spinal cord membranes were investigated in radioreceptor assays. [3H](+)-Pentazocine bound to a single, high affinity site (Kd = 1.2-1.6 nM) with increasing density along the neuraxis...

journal_title：European journal of pharmacology

authors： Kovács KJ,Larson AA

更新日期：1995-10-16 00:00:00

abstract：:Inflammatory processes are critical promoting factors of chronic pain states, mostly by inducing peripheral and central sensitization of the nociceptive system. These processes are associated with a massive increase in glutamatergic transmission, sometimes facilitated by spinal disinhibition. In this study, we used et...

journal_title：European journal of pharmacology

authors： Gazzo G,Girard P,Kamoun N,Verleye M,Poisbeau P

更新日期：2019-01-15 00:00:00

abstract：:Endothelin-1-(1-31) is a new bioactive 31-amino-acid-length peptide generated from big endothelin-1 by chymase or other chymotrypsin-type proteases with various pathophysiologic functions. In this study, we have detected the specific and monophasic binding of [125I]endothelin-1-(1-31) in porcine lung membranes. Compet...

journal_title：European journal of pharmacology

authors： Kitamura H,Cui P,Sharmin S,Yano M,Kido H

更新日期：2003-03-28 00:00:00

abstract：:The open field is a very popular animal model of anxiety-like behavior. An overview of the literature on the action elicited by effective or putative anxiolytics in animal subjected to this procedure indicates that classical treatments such as benzodiazepine receptor full agonists or 5-HT(1A) receptor full or partial ...

journal_title：European journal of pharmacology

authors： Prut L,Belzung C

更新日期：2003-02-28 00:00:00

abstract：:The gastric anti-secretagogue effects of cimetidine (a histamine H2-receptor antagonist) and of atropine (a non-selective muscarinic receptor antagonist) and pirenzepine (a selective muscarinic M1-receptor antagonist) were examined in conscious gastric fistula rats both under basal conditions and after stimulation wit...

journal_title：European journal of pharmacology

authors： Ekelund M,Håkanson R,Vallgren S

更新日期：1987-06-19 00:00:00

abstract：:Rolipram was characterized for its emetic, behavioral, cardiovascular and pulmonary activities in dogs, to assess its systemic pharmacology and potential bronchodilatory selectivity. At doses > or = 0.1 mg/kg i.v., rolipram induced emesis, anxiety, and stepping behaviors in conscious dogs, and increased heart rate and...

journal_title：European journal of pharmacology

authors： Heaslip RJ,Evans DY

更新日期：1995-11-24 00:00:00

abstract：:Since its clinical inception, tamoxifen (TAM) has proved to be a powerful tool in treating estrogen receptor-positive breast cancers while exhibiting manageable side effects. Although TAM was synthesized as an estrogen receptor antagonist, reports have found that a significant fraction of women with estrogen receptor-...

journal_title：European journal of pharmacology

authors： Radin DP,Patel P

更新日期：2016-06-15 00:00:00

abstract：:We have assessed the utility of the Cytosensor microphysiometer for studying the pharmacology of recombinant CRF receptors. Chinese hamster ovary cells stably expressing the human CRF1 or CRF2 receptor were perfused in the Cytosensor with bicarbonate-free Hams F12 (pH 7.4) containing 0.2% bovine serum albumin. The ran...

journal_title：European journal of pharmacology

authors： Smart D,Coppell A,Rossant C,Hall M,McKnight AT

更新日期：1999-08-27 00:00:00

abstract：:Statins are well-known inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which block the mevalonate pathway. The activity of statins not only decreases cholesterol levels but also ameliorates inflammation and modulates the immune system. In this study, we investigated the effects of simvastatin ...

journal_title：European journal of pharmacology

authors： Sahid MNA,Liu S,Kiyoi T,Maeyama K

更新日期：2017-11-05 00:00:00

abstract：:Naloxone is known to decrease, increase or have no effect on nociceptive thresholds. Here, using two commonly accepted pain-related behaviors (licking and flinching) associated with injection of noxious formalin into a hind paw in rats, naloxone (0.1-1 mg/kg s.c.) simultaneously decreases and increases nociceptive res...

journal_title：European journal of pharmacology

authors： Wheeler-Aceto H,Cowan A

更新日期：1993-05-19 00:00:00

abstract：:Cardiovascular and behavioral responses induced by intravenous administration of the serotonin (5-HT)1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), were studied in conscious normotensive rats either after a single administration, after repeated subcutaneous treatments (1 mg/kg daily for 3 day...

journal_title：European journal of pharmacology

authors： Kolbasa KP,McCall RB,Ludens JH

更新日期：1991-02-14 00:00:00

abstract：:Clonidine and other imidazolines, including phentolamine, inhibited the norepinephrine-elicited accumulation of cyclic AMP in brain slices via blockade or postsynpatic alpha-adrenoceptors. Clonidine (0.0125--0.050 mg/kg, i.p.) antagonized the increase in locomotor activity induced by amphetamine in a dose-dependent ma...

journal_title：European journal of pharmacology

authors： Skolnick P,Daly JW,Segal DS

更新日期：1978-02-15 00:00:00

abstract：:In animals given citalopram (10 mg/kg) twice daily for 14 days a further dose of 1 mg/kg, administered 24 h after the last dose, markedly increased cortical dialysate serotonin (5-hydroxytryptamine, 5-HT), but had no effect in control animals. The effect on dialysate 5-HT in the dorsal raphe was not increased by the c...

journal_title：European journal of pharmacology

authors： Invernizzi R,Bramante M,Samanin R

更新日期：1994-08-01 00:00:00

abstract：:Antiarrhythmic drugs have been considered to be transported by the organic cation transport system. The purpose of this study was to elucidate the molecular mechanism underlying the transport of antiarrhythmic drugs using cells from the second segment of the proximal tubule (S2) cells of mice expressing human-organic ...

journal_title：European journal of pharmacology

authors： Hasannejad H,Takeda M,Narikawa S,Huang XL,Enomoto A,Taki K,Niwa T,Jung SH,Onozato ML,Tojo A,Endou H

更新日期：2004-09-19 00:00:00

abstract：:Protective effects of OP-2507 [15-cis-(4-propylcyclohexyl)-16,17,18,19,20-pentanor-9-deoxy -9 alpha, 6-nitrilo-PGF1 methyl ester] against cerebral anoxia and edema were investigated in a variety of experimental models in mice and rats. OP-2507 given s.c. or p.o. led to a consistent and dose-dependent prolongation of s...

journal_title：European journal of pharmacology

authors： Masuda Y,Ochi Y,Ochi Y,Karasawa T,Hatano N,Kadokawa T,Okegawa T

更新日期：1986-04-29 00:00:00

abstract：:In vagotomized dogs, lesions of the lateral reticular nucleus (LRN) region did not change arterial blood pressure and sympathetic nerve activity. The hypertensive and tachycardic responses elicited by section of both carotid sinus nerves and both vagus nerves were not altered. However the sympathoinhibitory component ...

journal_title：European journal of pharmacology

authors： Laubie M,Schmitt H

更新日期：1983-08-05 00:00:00

abstract：:Multiple myeloma is an incurable hematological malignancy. Different studies demonstrated the occurrence of genetic and epigenetic alterations in multiple myeloma. Histone lysine methylation has emerged as a central epigenetic change in the organization of eukaryotic chromatin with far-reaching implications for the re...

journal_title：European journal of pharmacology

authors： Zhao F,Chen Y,Zeng L,Li R,Zeng R,Wen L,Liu Y,Zhang C

更新日期：2010-11-10 00:00:00

abstract：:Substituted benzamides such as metoclopramide, cisapride, zacopride, renzapride or BRL 20627, stimulate intestinal motility in various species. As they are antagonists at 5-HT3 and agonists at 5-HT4 receptors and as both mechanisms could potentially contribute to their gastrointestinal prokinetic effect, the underlyin...

journal_title：European journal of pharmacology

authors： Buchheit KH,Buhl T

更新日期：1991-11-26 00:00:00