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Fluoxetine attenuates morphine-induced locomotion and blocks morphine-sensitization.

Abstract：

:Repeated morphine treatments result in sensitization, an increase in the efficacy of morphine to stimulate locomotor activity. study examined the effects of increasing serotonin (5-hydroxytryptamine, 5-HT) transmission on morphine-sensitization. For five days rats were administered saline or 5.0 mg/kg fluoxetine prior to treatment with saline or 5.0 mg/kg morphine. Twenty-one days later, rats were tested for their locomotor response to 2.0 mg/kg morphine. Fluoxetine treatment attenuated the locomotor activating effect of acute morphine treatments and blocked the sensitized response to the morphine challenge. These results indicate that increased 5-HT transmission attenuates the locomotor stimulating effects of morphine and prevents the development of morphine-sensitization.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Sills TL,Fletcher PJ

doi

10.1016/s0014-2999(97)01308-3

subject

Has Abstract

pub_date

1997-10-22 00:00:00

pages

161-4

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(97)01308-3

journal_volume

337

pub_type

杂志文章

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