Upregulation of NMDA receptor subunit proteins in the cerebral cortex during diazepam withdrawal.

abstract：:Termination of signalling by G-protein-coupled receptors requires inactivation of the G alpha-subunits of heterotrimeric G-proteins and the re-association of G alpha- and G betagamma-subunits. Inactivation of G alpha-subunits is achieved by the hydrolysis of bound GTP by an intrinsic GTPase activity, which is consider...

journal_title：European journal of pharmacology

authors： Karakoula A,Tovey SC,Brighton PJ,Willars GB

更新日期：2008-06-10 00:00:00

abstract：:Rats were given powdered diet containing L-DOPA (together with the peripheral decarboxylase inhibitor carbidopa) for a period of 6 months. The estimated daily intake was in the range 20-30 mg/kg. Initially, at 1 week and 1 month, L-DOPA-fed rats exhibited enhanced spontaneous locomotor activity, but this fell to withi...

journal_title：European journal of pharmacology

authors： Pycock C,Dawbarn D,O'Shaughnessy C

更新日期：1982-04-23 00:00:00

abstract：:The effects of the serotonin (5-HT) precursor L-tryptophan on MDMA (3,4-methylenedioxymethamphetamine)-induced inhibition of dorsal raphe neuronal firing were characterized using extracellular single-unit recording and microdialysis techniques in the in vitro midbrain slice preparation. Pretreatment with L-tryptophan ...

journal_title：European journal of pharmacology

authors： Sprouse JS,Bradberry CW,Roth RH,Aghajanian GK

更新日期：1990-03-27 00:00:00

abstract：:The effect of furosemide on carbohydrate metabolism was studied in ob/ob mice. Intraperitoneal injection of a single dose of furosemide (200 mg/kg body weight) into fasted mice resulted in acute hyperglycaemia and two days after such a single dose, the mice showed fasting hyperglycaemia and glucose intolerance. Pancre...

journal_title：European journal of pharmacology

authors： Sandström PE,Sehlin J

更新日期：1988-03-15 00:00:00

abstract：:In this study, rutaecarpine was tested for its antiplatelet activities in human platelet-rich plasma. In human platelet-rich plasma, rutaecarpine (40-200 microM) inhibited aggregation stimulated by a variety of agonists (i.e., collagen, ADP, adrenaline and arachidonic acid). The antiplatelet activity of rutaecarpine (...

journal_title：European journal of pharmacology

authors： Sheu JR,Hung WC,Lee YM,Yen MH

更新日期：1996-12-30 00:00:00

abstract：:Vascular smooth muscle cells in culture are capable of secreting endothelin which is a vasoconstrictor and mitogenic peptide. The effect of glucocorticoids on endothelin release from vascular smooth muscle cells of the rat and rabbit aortas was investigated. Micromolar concentrations of dexamethasone and cortisol caus...

journal_title：European journal of pharmacology

authors： Kanse SM,Takahashi K,Warren JB,Ghatei M,Bloom SR

更新日期：1991-06-18 00:00:00

abstract：:The effects of the two enantiomers of the antidepressant nomifensine on catecholamine uptake were investigated using rat brain synaptosomes. According to the results from in vitro and ex vivo/in vitro studies, the inhibitory activity on catecholamine uptake resides entirely in the (+)-form of nomifensine. Further stud...

journal_title：European journal of pharmacology

authors： Schacht U,Leven M

更新日期：1984-02-17 00:00:00

abstract：:After prolonged stimulation, the delta-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human delta-opioid receptor. Morphine...

journal_title：European journal of pharmacology

authors： Navratilova E,Eaton MC,Stropova D,Varga EV,Vanderah TW,Roeske WR,Yamamura HI

更新日期：2005-09-20 00:00:00

abstract：:A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healthy volunteers. The equilibrium dissociation constant for binding by [3H]PK 1...

journal_title：European journal of pharmacology

authors： Gavish M,Weizman A,Karp L,Tyano S,Tanne Z

更新日期：1986-02-18 00:00:00

abstract：:The pruritogenic potency of tryptase and its involvement in anti-pruritic effect of intravenous nafamostat mesilate (NFM) were studied in mice. An intradermal injection of tryptase (0.05-1 ng/site) elicited scratching in ICR mice, while chymase was without effects at doses of 0.05-50 ng/site. The dose-response curve o...

journal_title：European journal of pharmacology

authors： Ui H,Andoh T,Lee JB,Nojima H,Kuraishi Y

更新日期：2006-01-13 00:00:00

abstract：:Local infusions of PYY (3-100 pmol.min-1) caused a slowly developing vasoconstriction of a long duration in the cat submandibular salivary gland. The vasoconstrictor action of PYY was also present after alpha-adrenoceptor blockade and in sympathectomized animals. Local APP infusions caused only weak vasoconstriction. ...

journal_title：European journal of pharmacology

authors： Lundberg JM,Tatemoto K

更新日期：1982-09-10 00:00:00

abstract：:Calcium channel blockers appear to reduce the cardiac toxicity of cocaine and some stimulant-induced behaviors. The present experiment was designed to test whether the internal state induced by cocaine is altered by the calcium antagonist nimodipine. Substitution tests with the calcium agonist BAY K 8644 were also con...

journal_title：European journal of pharmacology

authors： Callahan PM,Cunningham KA

更新日期：1990-09-04 00:00:00

abstract：:Opiates depress the potassium-induced efflux of [3H]noradrenaline from the mouse vas deferens in a concentration-dependent (the IC50 for normorphine was 1.5 microM), stereospecific and naloxone-reversible manner. As the concentration of sodium in the extracellular fluid was reduced, the inhibitory action of opiates wa...

journal_title：European journal of pharmacology

authors： Sim JA,Henderson G

更新日期：1981-04-09 00:00:00

abstract：:The aim of the present study was to further characterize [3H]clonidine binding in the ventrolateral medulla of the human brainstem, the region involved in the vasodepressor effect of imidazoline drugs of the clonidine type. Under basal conditions, [3H]clonidine can bind both to the imidazoline receptors and to the alp...

journal_title：European journal of pharmacology

authors： Bricca G,Greney H,Zhang J,Dontenwill M,Stutzmann J,Belcourt A,Bousquet P

更新日期：1994-01-01 00:00:00

abstract：:We studied the effects of inhaled formoterol (0.75 mg/ml, 60 breaths = 26 micrograms), a long-acting beta 2-adrenoceptor agonist, or of the more short-acting drug, salbutamol (25 mg/ml, 60 breaths = 875 micrograms), on acute airflow obstruction and airway microvascular leakage (MVL) induced by inhaled histamine in ane...

journal_title：European journal of pharmacology

authors： Tokuyama K,Lötvall JO,Löfdahl CG,Barnes PJ,Chung KF

更新日期：1991-01-25 00:00:00

abstract：:Chronic atypical absence seizures are a component of the Lennox-Gastaut syndrome, a disorder invariably associated with severe cognitive impairment in children. However, the cause of this intellectual delay remains unclear. The AY9944 model of chronic atypical absence seizures in rats reliably reproduces the electrogr...

journal_title：European journal of pharmacology

authors： Chan KF,Burnham WM,Jia Z,Cortez MA,Snead OC 3rd

更新日期：2006-07-10 00:00:00

abstract：:Pretreatment with the non-competitive NMDA (N-methyl-D-aspartate) antagonist MK801 (0.5, 1.0 mg/kg, s.c.) suppressed the behavioral signs of withdrawal in morphine-dependent rats. However, the same doses of MK801 that suppressed morphine withdrawal also simultaneously produced phencyclidine (PCP)-like behaviors. Pretr...

journal_title：European journal of pharmacology

authors： Rasmussen K,Fuller RW,Stockton ME,Perry KW,Swinford RM,Ornstein PL

更新日期：1991-05-02 00:00:00

abstract：:Many studies have demonstrated that cyclophosphamide (CPA) can affect hepatic cytochrome p450 (CYP) isoenzyme activity in animals. We have investigated the effect of CPA on gene expression of various CYP enzymes as well as beta-actin in the human acute promyelocytic leukemia cell line (HL-60S) and its multidrug-resist...

journal_title：European journal of pharmacology

authors： Xie HJ,Lundgren S,Broberg U,Finnström N,Rane A,Hassan M

更新日期：2002-08-09 00:00:00

abstract：:The ability of the kappa-opioid receptor agonist U69593 to attenuate the sensitization and cross-sensitization which develops to the conditioned rewarding effects of morphine and cocaine was examined using an unbiased place-preference conditioning procedure. The influence of U69593 treatment upon sensitization and cro...

journal_title：European journal of pharmacology

authors： Shippenberg TS,LeFevour A,Thompson AC

更新日期：1998-03-12 00:00:00

abstract：:The ontogenesis of kappa-opioid receptors has been studied in the postnatal period from day 5 to day 30 using the highly selective kappa-site ligand [3H]U-69593 in binding studies. Analyses of saturation curves revealed a marked increase in the binding capacities between day 5 and day 10 with no further increment in t...

journal_title：European journal of pharmacology

authors： Kitchen I,Kelly M,Viveros MP

更新日期：1990-01-03 00:00:00

abstract：:Curcumol is one of the major components of the essential oil of Rhizoma Curcumae, a common traditional Chinese medicine with anti-inflammatory properties. However, the anti-inflammatory activity and the underlying molecular mechanisms of this compound remain unclear. In the present study, the anti-inflammation effect ...

journal_title：European journal of pharmacology

authors： Chen X,Zong C,Gao Y,Cai R,Fang L,Lu J,Liu F,Qi Y

更新日期：2014-01-15 00:00:00

abstract：:Proliferation and migration of vascular smooth muscle cells (VSMCs) play crucial roles in the development of vascular restenosis. Our previous study showed that CCN4, namely Wnt1 inducible signaling pathway protein 1 (WISP1), significantly promotes proliferation and migration of rat VSMCs, but its mechanism remains un...

journal_title：European journal of pharmacology

authors： Lu S,Liu H,Lu L,Wan H,Lin Z,Qian K,Yao X,Chen Q,Liu W,Yan J,Liu Z

更新日期：2016-10-05 00:00:00

abstract：:We have reported previously that the dipeptidyl peptidase IV inhibitor Ile-Pro-Ile had an antihyperalgesic action in rats when given intrathecally in the carrageenan-induced hyperalgesia, as detected by the Randall-Selitto test. Vildagliptin, a non-peptide inhibitor of the same enzyme, which is already on the market a...

journal_title：European journal of pharmacology

authors： Király K,Lambeir AM,Szalai J,Szentirmay A,Luyten W,Barna I,Puskár Z,Kozsurek M,Rónai AZ

更新日期：2011-01-10 00:00:00

abstract：:Pulmonary arterial remodeling is a crucial cause of increased pulmonary artery pressure during pulmonary hypertension (PH). Recently, growing evidence has upheld the contribution of endothelial-mesenchymal transition (EndMT) to pulmonary arterial remodeling, but the underlying mechanisms remain largely unaddressed. mi...

journal_title：European journal of pharmacology

authors： Liu T,Zou XZ,Huang N,Ge XY,Yao MZ,Liu H,Zhang Z,Hu CP

更新日期：2019-11-15 00:00:00

abstract：:To test whether there is a common site of action for intravenous anaesthetics at the glycine receptor, the effects of binary combinations of thiopentone, pentobarbitone, methohexitone, and propofol have been tested on human alpha(1) glycine receptors expressed in Xenopus laevis oocytes using two-electrode voltage-clam...

journal_title：European journal of pharmacology

authors： Hadipour-Jahromy M,Daniels S

更新日期：2003-09-12 00:00:00

abstract：:Anticholinergic agents have important uses as bronchodilators for the treatment of obstructive airway diseases, both asthma and, more particularly, chronic obstructive pulmonary disease (COPD). Those in approved clinical use are synthetic quaternary ammonium congeners of atropine, and include ipratropium bromide, oxit...

journal_title：European journal of pharmacology

authors： Gross NJ

更新日期：2006-03-08 00:00:00

abstract：:This study uses immediate early transcription factor gene expression to map neuronal activation after a single exposure to the elevated X-maze. Exposure to this novel environment leads to widespread upregulation in the gene expression of c-fos, NGFI-A and NGFI-B (the nerve growth factor induced genes), but not c-jun n...

journal_title：European journal of pharmacology

authors： Hinks GL,Brown P,Field M,Poat JA,Hughes J

更新日期：1996-09-26 00:00:00

abstract：:Intravenous infusions of sodium nitroprusside (SNP) at doses of 20, 40 or 80 micrograms/kg min-1 for 30 min produced dose-related decrements in blood pressure in conscious rats fitted with indwelling aortic and vena caval catheters. Immediately upon termination of SNP infusions, blood pressure rebounded to levels whic...

journal_title：European journal of pharmacology

authors： Abukhres MM,Ertel RJ,Dixit BN,Vollmer RR

更新日期：1979-10-01 00:00:00

abstract：:The affinity and intrinsic activity of dopamine receptor agonists were determined at the human dopamine hD21 and hD4.4 receptors. (-)-3-Hydroxy-N-n-propylpiperidine ((-)3-PPP) had an intrinsic activity of 46% and 83%, whereas (+)-N-propylnorapomorphine ((+)-NPA) had intrinsic activities of 61% and 58% at the dopamine ...

journal_title：European journal of pharmacology

authors： Lahti RA,Mutin A,Cochrane EV,Tepper PG,Dijkstra D,Wikström H,Tamminga CA

更新日期：1996-04-22 00:00:00

abstract：:Cerebral vascular reactivity to prostaglandin E2 was investigated in newborn pigs using closed cranial windows. Exogenous prostaglandin E2 is a dilator of pial arterioles that elevates cyclic AMP in cortical cerebrospinal fluid. Pial arterioles are less sensitive to prostaglandin E2 than to the prostacyclin receptor a...

journal_title：European journal of pharmacology

authors： Parfenova H,Leffler CW

更新日期：1995-05-15 00:00:00