Abstract：
:Curcumol is one of the major components of the essential oil of Rhizoma Curcumae, a common traditional Chinese medicine with anti-inflammatory properties. However, the anti-inflammatory activity and the underlying molecular mechanisms of this compound remain unclear. In the present study, the anti-inflammation effect of curcumol on lipopolysaccharide (LPS)-induced RAW264.7 cells is demonstrated along with its underlying mechanisms. We show that curcumol inhibits LPS-induced NO production by suppressing iNOS mRNA expression and protein level but not iNOS activity. Moreover, curcumol inhibits LPS-induced production of TNF-α, IL-1β and IL-6 at both the transcriptional and translational levels. Further investigations reveal that these effects mainly act via suppressing JNK-mediated AP-1 rather than the NF-κB pathway; these effects include a decrease in the phosphorylation level of JNK and a direct inhibition of the activity of p-JNK. These data provide scientific molecular evidence that curcumol may be a potential lead compound for a novel anti-inflammatory drug because of its inhibitory activity on the production of various inflammatory mediators.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Chen X,Zong C,Gao Y,Cai R,Fang L,Lu J,Liu F,Qi Ydoi
10.1016/j.ejphar.2013.11.007subject
Has Abstractpub_date
2014-01-15 00:00:00pages
339-45eissn
0014-2999issn
1879-0712pii
S0014-2999(13)00854-6journal_volume
723pub_type
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