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Endothelial P2Y receptors induce hyperpolarisation of vascular smooth muscle by release of endothelium-derived hyperpolarising factor.

Abstract：

:The effects of P2Y receptor agonists on smooth muscle membrane potential in isolated ring segments of rat mesenteric artery were examined by intracellular microelectrodes. In the presence of inhibitors of nitric oxide-synthase and cyclo-oxygenase, the selective P2Y1 receptor agonist adenosine 5'-O-thiodiphosphate (ADPbetaS) induced endothelium-dependent membrane hyperpolarisations, which were abolished by a combination of the K+ channel inhibitors charybdotoxin and apamin, providing direct evidence that ADPbetaS releases endothelium-derived hyperpolarising factor (EDHF). 2-MethylthioATP and ATP, each which stimulates both endothelial P2Y receptors and P2X receptors on the smooth muscle cells, also elicited hyperpolarisation, but only after desensitisation of P2X receptors with alphabeta-methylATP indicating that simultaneous activation of P2X receptors may counteract the action of EDHF. In conclusion, activation of endothelial P2Y receptors induce release of EDHF.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Malmsjö M,Erlinge D,Högestätt ED,Zygmunt PM

doi

10.1016/s0014-2999(98)00848-6

subject

Has Abstract

pub_date

1999-01-08 00:00:00

pages

169-73

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(98)00848-6

journal_volume

364

pub_type

杂志文章

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