Reversal by [D-Ala2,D-Leu5]enkephalin of the dopamine transporter loss caused by methamphetamine.

abstract：:Pieces of rat brain incubated in oxygenated Tyrode solution were stimulated with the divalent cation ionophore A 23187. Incubation media were assayed for leukotriene (LT) C4-like immunoreactivity as well as for prostaglandin (PG) D2, 6-keto-PGF1 alpha and thromboxane (TX) B2 using specific and sensitive radioimmunoass...

journal_title：European journal of pharmacology

authors： Dembinska-Kieć A,Simmet T,Peskar BA

更新日期：1984-03-16 00:00:00

abstract：:To investigate cellular electrophysiologic alterations due to lipid peroxidation of the cell membrane by free radicals as a possible cause of coronary reperfusion arrhythmias, we studied the effects of t-butyl hydroperoxide on the spontaneous action potential and membrane currents of the rabbit sinoatrial and atrioven...

journal_title：European journal of pharmacology

authors： Satoh N,Nishimura M,Watanabe Y

更新日期：1995-03-16 00:00:00

abstract：:Obesity-associated non-alcoholic fatty liver disease (NAFLD) increases coagulation and inflammation. We hypothesized that (S)YS-51, an agent found to be beneficial in animal models of sepsis, may reduce NAFLD in high-fat diet (HFD) mice by reducing coagulation and inflammation. C57BL/6 mice were fed either a chow diet...

journal_title：European journal of pharmacology

authors： Park EJ,Kim YM,Kim HJ,Jang SY,Oh MH,Lee DH,Chang KC

更新日期：2016-10-05 00:00:00

abstract：:The nature of the inhbitory non-adrenergic non-cholinergic (NANC) neurotransmitter responsible for neurogenic relaxation of rat duodenum was studied with in vitro techniques. Adenosine 5'-triphosphate (ATP)(1 mM), gamma-aminobutyric acid (GABA, 1 mM), dimethylphenylpiperazinium (DMPP, 0.1 mM) and field stimulation (60...

journal_title：European journal of pharmacology

authors： Manzini S,Maggi CA,Meli A

更新日期：1985-07-31 00:00:00

abstract：:Increasing concentrations of the functional antagonist carbachol resulted in a shift to the right of the dose-response curves for (--)-isoproterenol-induced positive chronotropic and inotropic responses and a reduction of the maximum degree of response that could be produced relative to that produced by theophylline. ...

journal_title：European journal of pharmacology

authors： Buckner CK,Torphy T,Costa DJ

更新日期：1978-02-01 00:00:00

abstract：:Cannabinoid CB(2) receptors have been implicated in antinociception in animal models of both acute and chronic pain. We evaluated the role both cannabinoid CB(1) and CB(2) receptors in mechanonociception in non-arthritic and arthritic rats. The antinociceptive effect of Delta(9)-tetrahydrocannabinol (Delta(9)THC) was ...

journal_title：European journal of pharmacology

authors： Cox ML,Haller VL,Welch SP

更新日期：2007-09-10 00:00:00

abstract：:The prophylactic effect of serotonin uptake inhibitors, imipramine and fluoxetine, against motion sickness was investigated in Suncus murinus. Imipramine (s.c.) and fluoxetine (i.p.) inhibited motion-induced emesis dose dependently with ID50 values of 1.7 and 26 mg/kg, respectively. The results suggest that increasing...

journal_title：European journal of pharmacology

authors： Okada F,Saito H,Matsuki N

更新日期：1996-08-01 00:00:00

abstract：:Internal and external carotid vascular resistances were measured, in anaesthetized monkeys, to asses the direct cranial vascular effects of i.v. methysergide, pizotifen and ergotamine, and their effects on the cranial vascular responses to the constrictors 5-hydroxytryptamine and noradrenaline and the dilators histami...

journal_title：European journal of pharmacology

authors： Mylecharane EJ,Spira PJ,Misbach J,Duckworth JW,Lance JW

更新日期：1978-03-01 00:00:00

abstract：:Galantamine is a drug in clinical use for the treatment of Alzheimer's disease, but its mechanism(s) of action remains controversial. Here we addressed the question whether galantamine could potentiate neurotransmitter release by inhibiting small conductance Ca2+ -activated K+ channels (KCa2). Galantamine potentiated ...

journal_title：European journal of pharmacology

authors： Alés E,Gullo F,Arias E,Olivares R,García AG,Wanke E,López MG

更新日期：2006-10-24 00:00:00

abstract：:Alterations in iron homeostasis are well described in obese patients. The effects of iron chelators on adipose tissue and other organs affected by obesity have been the interest of experimental studies, both in vivo and in vitro. The aim of this review was to update the available information indicating the potential o...

journal_title：European journal of pharmacology

authors： Rodrigues de Morais T,Gambero A

更新日期：2019-10-15 00:00:00

abstract：:Administration of ovalbumin by aerosol to sensitised rats produced a rapid (15 min) protein exudation in different airway tissues, as determined by Evans blue staining. This was associated with marked mast cell degranulation determined by histological examination, with there being no difference between mucosal and con...

journal_title：European journal of pharmacology

authors： Damazo AS,Tavares de Lima W,Perretti M,Oliani SM

更新日期：2001-08-24 00:00:00

abstract：:Alopecia is resulted from various factors that can decrease the regeneration capability of hair follicles and affect hair cycles. This process can be devastating physically and psychologically. Nevertheless, the available treatment strategies are limited, and the therapeutic outcomes are not satisfactory. According to...

journal_title：European journal of pharmacology

authors： Yuan AR,Bian Q,Gao JQ

更新日期：2020-08-15 00:00:00

abstract：:DAA-I (des-aspartate-angiotensin I), an endogenous angiotensin, had been shown earlier to ameliorate animal models of cardiovascular diseases via the angiotensin AT1 receptor and prostaglandins. The present study investigated further the action of DAA-I on the release of PGE2, PGI2, PGF2α and TXA2 in HUVEC. 10(-11)-10...

journal_title：European journal of pharmacology

authors： Wen Q,Lee KO,Sim SZ,Xu XG,Sim MK

更新日期：2015-12-05 00:00:00

abstract：:The ability of the novel non-glucocorticoid 21-aminosteroid U74006F to protect against the development of hemorrhagic shock was examined in pentobarbital-anesthetized cats. The animals were hemorrhaged to a mean arterial blood pressure (MAP) of 45-50 mm Hg where they were held for 2 h. At the end of the hemorrhage per...

journal_title：European journal of pharmacology

authors： Hall ED,Yonkers PA,McCall JM

更新日期：1988-03-01 00:00:00

abstract：:Vasodilatory responses to bradykinin (BK) and acetylcholine (ACh) were compared in phenylephrine preconstricted perfused kidneys from 30-week-old male stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). Responses to ACh did not differ between kidneys from SHRSP and WHY. BK-in...

journal_title：European journal of pharmacology

authors： Stier CT Jr,Selig N,Itskovitz HD

更新日期：1992-01-14 00:00:00

abstract：:The effects of indapamide on contractile responses in various isolated artery rings and on spontaneous mechanical activity in portal vein segments were investigated. Arteries used were: rabbit aorta, mesenteric (fifth branch), femoral and basilar, and sheep coronary arteries. 45Ca2+ uptake was also analysed in rabbit ...

journal_title：European journal of pharmacology

authors： Del Rio M,Chulia T,Gonzalez P,Tejerina T

更新日期：1993-11-30 00:00:00

abstract：:Despite the well-known involvement of the peripheral sympathetic abnormalities in the development of cardiovascular complications of cholestasis, the role of the central sympathetic system is still elusive. The goal of this study was to evaluate the effects of central sympathetic tone reduction, through clonidine admi...

journal_title：European journal of pharmacology

authors： Tavakoli S,Hajrasouliha AR,Jabehdar-Maralani P,Ebrahimi F,Sadeghipour H,Dehghani M,Shafaroodi H,Dehpour AR

更新日期：2006-08-07 00:00:00

abstract：:The binding characteristics of compound 48/80 were examined using rat mast cells and fractionated 14C-labeled compound 48/80 components at 4 degrees C in vitro where no degranulation of the cells occurred. The binding potencies of these components in the presence of Ca2+ generally paralleled their histamine releasing ...

journal_title：European journal of pharmacology

authors： Koibuchi Y,Ichikawa A,Nakagawa M,Tomita K

更新日期：1985-09-24 00:00:00

abstract：:The present study was conducted with an aim to explore the possible role of naringin against ischemia reperfusion induced-neurobehavioral alterations, oxidative damage, cellular and histopathological alterations in cortex, striatum, hippocampus areas of brain. Male Wistar rats (200-220 g) were subjected to bilateral c...

journal_title：European journal of pharmacology

authors： Gaur V,Aggarwal A,Kumar A

更新日期：2009-08-15 00:00:00

abstract：:Patients with spinal cord injury (SCI) undergo severe loss of bone mineral below the level of lesion, and data on available treatment options after SCI is scarce. The aim of this work was to investigate the therapeutic effect of cannabidiol (CBD), a non-psychoactive cannabis, on sublesional bone loss in a rat model of...

journal_title：European journal of pharmacology

authors： Li D,Lin Z,Meng Q,Wang K,Wu J,Yan H

更新日期：2017-08-15 00:00:00

abstract：:The NMDA receptor agonist quinolinic acid (9 mM) was infused i.c.v. via ALZET osmotic minipumps for 2 weeks. This treatment produced a persistent, short-term memory deficit in the T-maze. Autoradiography revealed a decrease in the density of choline uptake sites in the hippocampus. Parallel s.c. infusion by another mi...

journal_title：European journal of pharmacology

authors： Misztal M,Frankiewicz T,Parsons CG,Danysz W

更新日期：1996-01-18 00:00:00

abstract：:Interleukin-6 (IL-6) is a key proinflammatory cytokine which plays a central role in the pathogenesis of periodontal disease. Host modulatory agents targeting at inhibiting IL-6, therefore, appear to be beneficial in slowing the progression of periodontal disease and potentially reducing destructive aspects of the hos...

journal_title：European journal of pharmacology

authors： Choi EY,Jin JY,Choi JI,Choi IS,Kim SJ

更新日期：2014-04-15 00:00:00

abstract：:Activation of imidazoline receptors in the central nervous system has protective effect on several types of arrhythmias. We demonstrated that centrally administered rilmenidine, a selective imidazoline receptor agonist, prevented adrenaline-induced arrhythmias during halothane anaesthesia. However, detailed myocardial...

journal_title：European journal of pharmacology

authors： Yamanaka H,Hayashi Y,Iwasaki M,Kamibayashi T,Yamatodani A,Mashimo T

更新日期：2010-11-25 00:00:00

abstract：:Drugs belonging to different chemical classes having the ability to improve behavioral performance in animal learning and memory tests may share the common ability to stimulate protein kinase C activity in rat brain cortex. In vitro acetyl-L-carnitine (100 nM) promoted in rat brain cortex slices a significant increase...

journal_title：European journal of pharmacology

authors： Pascale A,Milano S,Corsico N,Lucchi L,Battaini F,Martelli EA,Trabucchi M,Govoni S

更新日期：1994-11-14 00:00:00

abstract：:Nomifensine, at a dose of 40 mg/kg, slightly but significantly increased rat striatal acetylcholine 60 min after i.p. administration without affecting choline levels or choline O-acetyltransferase and cholinesterase activities. This drug had no effect on brainstem acetylcholine. In contrast, d-amphetamine and desipram...

journal_title：European journal of pharmacology

authors： Garattini S,Consolo S,Chittò G,Peri G,Ladinsky H

更新日期：1976-01-01 00:00:00

abstract：:The overactivation of glutamate receptors is a major cause of Ca(2+) overload in cells, potentially leading to cell damage and death. There is an abundance of agents and mechanisms by which glutamate receptor activation can be prevented or modulated in order to control these effects. They include the well-established,...

journal_title：European journal of pharmacology

authors： Stone TW,Addae JI

更新日期：2002-07-05 00:00:00

abstract：:Given the differences in the dopamine neurotransmission between the shell and the core of the nucleus accumbens, as well as the differential involvement of these two domains in oral behaviour of rats, it was decided to determine whether or not dopamine D1 and/or dopamine D2 receptors differentially direct oral behavio...

journal_title：European journal of pharmacology

authors： Cools AR,Miwa Y,Koshikawa N

更新日期：1995-11-03 00:00:00

abstract：:Lung fibrosis is a common side effect of the chemotherapeutic agent, bleomycin. Current evidence suggests that reactive oxygen species may play a key role in the development of lung fibrosis. The present study examined the effect of mesna on bleomycin-induced lung fibrosis in rats. Animals were divided into three grou...

journal_title：European journal of pharmacology

authors： El-Medany A,Hagar HH,Moursi M,At Muhammed R,El-Rakhawy FI,El-Medany G

更新日期：2005-02-10 00:00:00

abstract：:Thapsigargin (TG), an inhibitor of Ca(2+) ATPase pumps in the endoplasmic reticulum (ER), inhibits replication of human vascular smooth muscle cell (hVSMC) at low nM concentrations. TG blocks replication of other cell types through promotion of ER stress (ERS). In order to determine whether ERS may mediate the cytosta...

journal_title：European journal of pharmacology

authors： Shukla N,Wan S,Angelini GD,Jeremy JY

更新日期：2013-08-15 00:00:00

abstract：:Morphine produced a dose-dependent increase in the activity of dopamine-containing neurons in the substantia nigra and ventral tegmental area recorded from mouse brain slices in vitro. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects are the result of...

journal_title：European journal of pharmacology

authors： Trulson ME,Arasteh K

更新日期：1985-08-07 00:00:00