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Chronic antidepressant administration fails to attenuate apomorphine-induced decreases in rat striatal dopamine metabolites.

Abstract：

:The responsiveness of the rat striatal dopamine (DA) receptor system to apomorphine (APO) was assessed after 10 days of antidepressant administration. Desipramine (DMI), dothiepin (DOTH), iprindole (IPR) and nomifensine (NOM) were administered intra-peritoneally, twice daily, to rats for 10 days and 42 h after the last drug dose, animals were injected with APO (25 or 200 micrograms/kg s.c., 15 min) or vehicle. Striatal content of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), assayed using a recently developed high-performance liquid chromatography-electrochemical detection (HPLC-ECD) method, showed that prolonged administration of all four antidepressant drugs failed to modify the effect of APO on DA metabolism. The results of these experiments therefore do not provide evidence to support the suggestion that subsensitivity in presynaptic DA 'autoreceptors' is a significant biochemical correlate of chronic antidepressant drug administration.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Diggory GL,Buckett WR

doi

10.1016/0014-2999(84)90617-4

subject

Has Abstract

pub_date

1984-10-15 00:00:00

pages

257-63

issue

3-4

eissn

0014-2999

issn

1879-0712

pii

0014-2999(84)90617-4

journal_volume

105

pub_type

杂志文章

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