Effects of WAY 100635 on antipsychotic-induced catalepsy in 5-HT depleted animals: a role for tonic activation of 5-HT(1A) receptors.

abstract：:The intracerebroventricular (i.c.v.) administration of 10 micrograms of atrial natriuretic peptide (ANP) stimulated spontaneous gastric acid secretion in anaesthetized rats, whereas this dose of ANP was without any effect after i.v. injection. The secretagogue action of i.c.v. administered ANP was totally abolished by...

journal_title：European journal of pharmacology

authors： Puurunen J,Ruskoaho H

更新日期：1987-09-23 00:00:00

abstract：:Ouabain- and bumetanide-resistant potassium fluxes were measured in human erythrocytes incubated in a medium containing calcium and a calcium ionophore. Pharmacological concentrations of rat atrial natriuretic peptide stimulated these fluxes. Although human erythrocytes lack atrial natriuretic peptide receptors, our r...

journal_title：European journal of pharmacology

authors： Esparza N,Díez J

更新日期：1989-07-18 00:00:00

abstract：:Adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, adenine and inosine were injected intradermally into the backs of human volunteers. ATP, ADP and AMP evoked weal and flare responses in the skin in a dose dependent manner. The rank order of potency was ATP greater tha...

journal_title：European journal of pharmacology

authors： Coutts AA,Jorizzo JL,Eady RA,Greaves MW,Burnstock G

更新日期：1981-12-17 00:00:00

abstract：:The amyloid precursor protein (APP) has been mainly studied in its role in the production of amyloid β peptides (Aβ), because Aβ deposition is a hallmark of Alzheimer's disease. Although several studies suggest APP has physiological functions, it is still controversial. We previously reported that APP increased glial ...

journal_title：European journal of pharmacology

authors： Kwak YD,Marutle A,Dantuma E,Merchant S,Bushnev S,Sugaya K

更新日期：2011-01-10 00:00:00

abstract：:The correlation between the Phosphoinositide 3-kinase (PI3K) axis and crucial mechanisms involved in the maintenance of the neoplastic nature of multiple myeloma (MM) has recently evolved a general agreement that PI3K inhibition-based therapies could construct an exciting perspective for the future treatment strategie...

journal_title：European journal of pharmacology

authors： Safaroghli-Azar A,Bashash D,Kazemi A,Pourbagheri-Sigaroodi A,Momeny M

更新日期：2019-01-05 00:00:00

abstract：:Macrophages play important roles in the healing and remodeling of cardiac tissues after myocardial ischemia/reperfusion (MI/R) injury. Here we investigated the potential effects of salvianolic acid B (SalB), one of the abundant and bioactive compounds extracted from Chinese herb Salvia Miltiorrhiza (Danshen), on macro...

journal_title：European journal of pharmacology

authors： Zhao M,Li F,Jian Y,Wang X,Yang H,Wang J,Su J,Lu X,Xi M,Wen A,Li J

更新日期：2020-03-15 00:00:00

abstract：:Primary cultures of rat cerebellar granule neurons express 5-lipoxygenase, an enzyme from the inflammatory pathway of arachidonic acid. Outside the central nervous system (CNS) 5-lipoxygenase participates in cell proliferation. We hypothesized that 5-lipoxygenase is needed for proliferation of immature cerebellar gran...

journal_title：European journal of pharmacology

authors： Uz T,Manev R,Manev H

更新日期：2001-04-20 00:00:00

abstract：:The effect of ouabain (10(-3) M) on contractile responses of SHR (spontaneously hypertensive rat) and WKY (Wistar-Kyoto rat) aortas and mesenteric arteries was studied. Ouabain addition caused a rapid contraction of aortic strips with a steeper rate of rise and a larger maximal force development in strips from SHR tha...

journal_title：European journal of pharmacology

authors： Morita S,Iwasaki T,Nagai K,Miyata S,Kawai Y

更新日期：1988-07-14 00:00:00

abstract：:The pharmacological characteristics of the binding of [3H]8-OH-DPAT ([3H]8-hydroxy-2(di-n-propylamino)tetralin, [125I]CYP ((-)[125I]iodocyanopindolol) (in the presence of 30 microM (-)isoprenaline) and [3H]mesulergine to 5-HT1 recognition sites were studied in rat and pig brain membranes. [3H]8-OH-DPAT bound in rat an...

journal_title：European journal of pharmacology

authors： Hoyer D,Engel G,Kalkman HO

更新日期：1985-11-26 00:00:00

abstract：:Chronic infection with the liver fluke, Opisthorchis viverrini, induces advanced periductal fibrosis and is a relative risk factor for cholangiocarcinoma in Southeastern Asia. We examined the reducing effect of curcumin on hepatobiliary fibrosis using O. viverrini-infected hamsters supplemented with dietary 1% curcumi...

journal_title：European journal of pharmacology

authors： Pinlaor S,Prakobwong S,Hiraku Y,Pinlaor P,Laothong U,Yongvanit P

更新日期：2010-07-25 00:00:00

abstract：:4,6,6-Trimethylcaprolactam antagonised GABAA receptor-mediated contractile responses in guinea-pig isolated ileum, displacing the GABA dose-response curve to the right in a non-parallel manner, and causing a depression of the maximum response. Pentobarbitone not only potentiated the GABAA receptor-mediated contraction...

journal_title：European journal of pharmacology

authors： Kerr DI,Ong J,Prager RH,Ward DA

更新日期：1986-05-13 00:00:00

abstract：:Electrical field stimulation of the isolated adventitial and intima-medial layers of rabbit aorta preloaded with 3H-noradrenaline elicited a 3H outflow. The initial 3H outflow from adventitia was independent of external Ca2+ concentration. Each of the subsequent 3H outflows was mainly Ca2+ sensitive. All stimulation-i...

journal_title：European journal of pharmacology

authors： Schrold J,Nedergaard OA

更新日期：1976-10-01 00:00:00

abstract：:Growing evidence recommends incorporating the concept of drug-target residence times within drug development and screening programs. For many targets, systematic research for binding kinetics is emerging and reported, as in case of the histamine H3 receptor. Alternatively, fluorescent methods based on Foerster resonan...

journal_title：European journal of pharmacology

authors： Reiner D,Stark H

更新日期：2019-04-05 00:00:00

abstract：:This study evaluated the coronary dopamine receptors by using the dopamine D1 receptor agonist fenoldopam, dopamine D2 receptor agonist propylbutyldopamine, and their selective antagonists SCH23390 and domperidone. Left circumflex coronary flow (CF), coronary perfusion pressure at constant flow, left ventricular hemod...

journal_title：European journal of pharmacology

authors： Zhao RR,Fennell WH,Abel FL

更新日期：1990-11-06 00:00:00

abstract：:Levtiracetam (Lev), an inhibitor of SV2A (synaptic vesicle protein A2), affected the ATP-dependent priming of Ca(2+)-regulated exocytosis in antral mucous cells of guinea pig. In antral mucous cells, the Ca(2+)-regulated exocytosis, which is activated by acetylcholine (ACh), consists of an initial peak that declines r...

journal_title：European journal of pharmacology

authors： Harada S,Tanaka S,Takahashi Y,Matsumura H,Shimamoto C,Nakano T,Kuwabara H,Sawabe Y,Nakahari T

更新日期：2013-12-05 00:00:00

abstract：:Several effects of bacterial endotoxins involve an opioid pathway and neuropeptide FF is an endogenous peptide known to modulate opioid activity, mainly in the central nervous system. The aim of this study was to investigate in rats the role of central neuropeptide FF receptors in intestinal motor disturbances and bod...

journal_title：European journal of pharmacology

authors： Million M,Fioramonti J,Zajac JM,Buéno L

更新日期：1997-09-03 00:00:00

abstract：:We examined whether estrogen negatively modulates cannabinoid-induced regulation of food intake, core body temperature and neurotransmission at proopiomelanocortin (POMC) synapses. Food intake was evaluated in ovariectomized female guinea pigs abdominally implanted with thermal DataLoggers and treated s.c. with the ca...

journal_title：European journal of pharmacology

authors： Kellert BA,Nguyen MC,Nguyen C,Nguyen QH,Wagner EJ

更新日期：2009-11-10 00:00:00

abstract：:The effects of three K+ channel openers on lysozyme output from submucosal gland serous cells and epithelial albumin transport following maintained submaximal stimulation by the secretagogues methacholine and phenylephrine were examined in the ferret trachea in vitro preparation. The K+ channel openers Ro 31-6930, 2-(...

journal_title：European journal of pharmacology

authors： Griffin A

更新日期：1995-07-14 00:00:00

abstract：:Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum. The study investigated the effects and mechanisms of aloe-emodin-induced cell death in human lung squamous cell carcinoma cell line CH27. Aloe-emodin (40 microM)-induced CH27 cell apoptosis w...

journal_title：European journal of pharmacology

authors： Lee HZ,Hsu SL,Liu MC,Wu CH

更新日期：2001-11-23 00:00:00

abstract：:Androgens relax several smooth muscles, including the airways. They also contract ileum and myocardium via nongenomic mechanisms. To find out whether androgens modulate airway smooth muscles in different species and further assess their mechanism of action, regarding the role of beta-adrenoceptors, polyamines and extr...

journal_title：European journal of pharmacology

authors： Bordallo J,de Boto MJ,Meana C,Velasco L,Bordallo C,Suárez L,Cantabrana B,Sánchez M

更新日期：2008-12-28 00:00:00

abstract：:As part of a program aimed at designing irreversible antagonists of the stimulant and reinforcing properties of cocaine, derivatives of GBR-12783 containing electrophilic substituents were synthesized. GBR-12783, a potent and selective inhibitor of both stimulant binding and dopamine transport, was modified to incorpo...

journal_title：European journal of pharmacology

authors： Deutsch HM,Schweri MM,Culbertson CT,Zalkow LH

更新日期：1992-09-22 00:00:00

abstract：:Cervical cancer is the third most prevalent cancer among women worldwide. Theanine from tea and its derivatives show some anticancer activities. However, the role of theanine and its derivatives against human cervical cancer and the molecular mechanisms of action remain unclear. Thus, in this study, we aim to investig...

journal_title：European journal of pharmacology

authors： Liu J,Sun Y,Zhang H,Ji D,Wu F,Tian H,Liu K,Zhang Y,Wu B,Zhang G

更新日期：2016-11-15 00:00:00

abstract：:Three apparently distinct pertussis toxin (PTX)-sensitive substrates, with Mrs of 39, 40 and 41 kDa, were identified in membranes prepared from the sino-atrial (SA) node and right atrium of bovine heart. Based on their biochemical characterization, the effects of guanine nucleotides/MgCl2 on their PTX-catalyzed [32P]A...

journal_title：European journal of pharmacology

authors： Braun AP,Gupta RC,Sulakhe PV

更新日期：1990-07-31 00:00:00

abstract：:The effects of clonidine and dl-propranolol on negative pressure breathing-induced diuresis in chloralose-anaesthetized dog were studied. Clonidine (10 microgram/kg i.v.) suppressed the diuretic response, whereas dl-propranolol (1 mg/kg i.v.) was inactive. ...

journal_title：European journal of pharmacology

authors： Montastruc P,Montastruc JL,Tran LD

更新日期：1981-07-10 00:00:00

abstract：:Isolated rat mast cells were used to study whether ionophore A23187 could induce histamine release by mobilizing cellular calcium. The histamine release was a slow process which was completed after about 20 min incubation with A23187. The A23187-induced histamine release was inhibited after incubation of the cells wit...

journal_title：European journal of pharmacology

authors： Johansen T

更新日期：1980-04-04 00:00:00

abstract：:The relation of the structure of 31 quaternary ammonium compounds (28 inhibitors; 3 substrate analogues) with their effects on the activity of acetylcholinesterase (EC 3.1.1.7; AChE) was studied. The compounds were structurally related to the natural substrate acetylcholine (ACh). All bear a trimethylammonium moiety a...

journal_title：European journal of pharmacology

authors： Thanei-Wyss P,Waser PG

更新日期：1989-05-11 00:00:00

abstract：:Pregnant rats were infused with phentermine plus dexfenfluramine from days 3 through 17 of gestation. Control rats were either pair-fed or were fed ad libitum. There were no effects of prenatal drug treatment on number of offspring, their birth weights, or on their motor coordination assessed at 11 days of age. Mother...

journal_title：European journal of pharmacology

authors： Bratter J,Gessner IH,Rowland NE

更新日期：1999-03-26 00:00:00

abstract：:The role of nitric oxide (NO) in the vagal cholinergic-mediated cytoprotective effect of intracisternal (i.c.) injection of the stable thyrotropin-releasing hormone (TRH) analog, RX 77368, was investigated in conscious rats. RX 77368 (1.5 ng i.c.) reduced by 88% gastric hemorrhagic lesions induced by oral administrati...

journal_title：European journal of pharmacology

authors： Király A,Sütö G,Taché Y

更新日期：1993-08-24 00:00:00

abstract：:Changrolin (2, 6-bis[pyrrolidin-1-ylmethyl]-4-[quinazolin-4-ylamino] phenol) is an anti-arrhythmic drug derived from β-dichroine, an active component of the Chinese medicinal herb, Dichroa febrifuga Lour. To elucidate the mechanism underlying the anti-arrhythmic effect of changrolin, we used the whole-cell patch-clamp...

journal_title：European journal of pharmacology

authors： Chen WH,Yang D,Wang WY,Zhang J,Wang YP

更新日期：2010-11-25 00:00:00

abstract：:Spinorphin has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase), and tynorphin has been synthesized as a more potent inhibitor of dipeptidyl aminopeptidase III. In this s...

journal_title：European journal of pharmacology

authors： Yamazaki T,Honda M,Yamamoto Y,Hazato T,Ono H

更新日期：2001-02-16 00:00:00