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The effect of troxypyrrolidinium, a choline uptake inhibitor, on the excitatory innervation of the rat urinary bladder.

Abstract：

:Troxypyrrolidinium, a choline uptake inhibitor, reduced but failed to abolish responses of the rat urinary bladder to electrical stimulation at 1-100 Hz although it reduced acetylcholine output during stimulation at 10 Hz to a level similar to that of spontaneous release. Inhibition of the response to stimulation was more complete at faster rates of stimulation and was partially reversed by choline. Troxypyrrolidinium produced a greater inhibition of the 'tonic' component of the response to electrical stimulation than of the 'phasic' component. Hemicholinium-3 or hyoscine produced a similar selective effect on the 'tonic' component. Hemicholinium-3 also reduced acetylcholine output during electrical stimulation to a similar extent as troxypyrrolidinium but hyoscine increased transmitter output. The results support the concept of a second transmitter in the excitatory innervation of the bladder.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Choo LK,Mitchelson F

doi

10.1016/0014-2999(80)90131-4

subject

Has Abstract

pub_date

1980-02-08 00:00:00

pages

293-301

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(80)90131-4

journal_volume

61

pub_type

杂志文章

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