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Lack of effect of atrial natriuretic factor on the tone induced in rat portal vein by platelet-activating factor.

Abstract：

:The spontaneous myogenic activity of the isolated rat portal vein was inhibited by atrial natriuretic factor or by sodium nitroprusside. These compounds were not effective on the tone induced by PAF-acether or carbachol. 8-Bromo cyclic GMP and dibutyryl cyclic AMP inhibited myogenic activity and reduced the agonist-induced contractions. Only dibutyryl-cyclic AMP significantly inhibited the PAF-acether-induced contractile responses. These results indicate that the tone induced by PAF-acether can be used to discriminate between drugs which selectively increase cyclic nucleotide levels.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Hellegouarch A,Auguet M,Guillon JM,Baranes J,Pirotzky E,Braquet P

doi

10.1016/0014-2999(88)90239-7

subject

Has Abstract

pub_date

1988-01-12 00:00:00

pages

245-8

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(88)90239-7

journal_volume

145

pub_type

杂志文章

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