Phosphoinositide hydrolysis mediated by histamine H1-receptors in rat brain cortex.

abstract：:Therapeutic angiogenesis has emerged as an attractive approach for the management of peripheral arterial disease in diabetic patients. Oxidative stress generated and aggravated by prolonged hyperglycemia may interfere with and destroy the newly formed blood vessels. Angiogenic effect of simvastatin has been reported; ...

journal_title：European journal of pharmacology

authors： El-Azab MF,Hazem RM,Moustafa YM

更新日期：2012-09-05 00:00:00

abstract：:The competitive reversible beta-adrenoceptor antagonist activity of Ro 03-5255 [1-(5-acetylaminobenzfuran-2-yl)-2-isopropylaminoethanol] upon isoprenaline-induced increases of the rate and tension of guinea-pig isolated atria is described. The chlorinated derivative [Ro 03-7894; 1-[5-chloracetylaminobenzfuran-2-yl)-2-...

journal_title：European journal of pharmacology

authors： Nicholson CD,Broadley KJ

更新日期：1978-12-01 00:00:00

abstract：:A major limitation of cancer treatment is the ability of cancer cells to develop resistance to chemotherapeutic drugs, by the establishment of multidrug resistance. Here, we characterize MC70 as ABC transporters inhibitor and anticancer agent, alone or with chemotherapy. MC70 was analyzed for its interaction with ABCB...

journal_title：European journal of pharmacology

authors： Azzariti A,Quatrale AE,Porcelli L,Colabufo NA,Cantore M,Cassano G,Gasparre G,Iannelli G,Tommasi S,Panaro MA,Paradiso A

更新日期：2011-11-16 00:00:00

abstract：:Treatment of rat reticulocytes with tetradecanoyl phorbol acetate (TPA), a tumor-promoting phorbol ester which activates protein kinase C, resulted in an about 50% decrease in the stimulation of adenylate cyclase activity by a subsequent challenge with a beta-adrenoceptor agonist. This phenomenon mimics agonist-induce...

journal_title：European journal of pharmacology

authors： Yamashita A,Kurokawa T,Une Y,Ishibashi S

更新日期：1988-07-07 00:00:00

abstract：:Co-dergocrine (Hydergine), an ergot preparation composed of four dihydrogenated peptide ergot alkaloids (dihydroergocornine, dihydroergocristine, dihydro-alpha-ergokryptine, dihydro-beta-ergokryptine, 3:3:2:1), has been reported to exert in vivo effects suggesting an interaction with dopaminergic systems. The present ...

journal_title：European journal of pharmacology

authors： Markstein R

更新日期：1982-12-24 00:00:00

abstract：:Morphine and aspartic acid were administered separately and in combination to 80 rats divided into 8 groups. Ten and 20 min following the injections, brain, liver and kidney L-asparaginase activity was determined. Morphine decreased brain and liver L-asparaginase activity and increased that of kidney. Aspartic acid co...

journal_title：European journal of pharmacology

authors： Koyuncuoğlu H,Keyer-Uysal M,Berkman K,Güngör M,Genç EM

更新日期：1979-12-20 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), a main flavanol of green tea, potently suppressed the urokinase-type plasminogen activator (uPA) expression in human fibrosarcoma HT 1080 cells. EGCG induced not only the suppression of the uPA promoter activity but also the destabilization of uPA mRNA. EGCG inhibited the phospho...

journal_title：European journal of pharmacology

authors： Kim MH,Jung MA,Hwang YS,Jeong M,Kim SM,Ahn SJ,Shin BA,Ahn BW,Jung YD

更新日期：2004-03-08 00:00:00

abstract：:Chronic administration of amphetamine to cats (twice daily, in doses increasing from 5 to 15 mg/kg over a 10-day period) elicited a number of behaviors e.g., limb flicking, abortive grooming, and excessive head shaking, which were originally proposed as an animal behavioral model for studying the actions of hallucinog...

journal_title：European journal of pharmacology

authors： Trulson ME,Crisp T

更新日期：1984-04-06 00:00:00

abstract：:We investigated whether intracerebroventricular (i.c.v.) infusion of the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine (N-Arg), impairs learning in male Sprague-Dawley rats (2-3 months old) in a 14-unit T-maze. Rats were pretrained in one-way active avoidance to a criterion of 13/15 avoidances of foot shock...

journal_title：European journal of pharmacology

authors： Ingram DK,Spangler EL,Kametani H,Meyer RC,London ED

更新日期：1998-01-02 00:00:00

abstract：:Methadone used for opioid dependence therapy is associated with increased pain sensitivity. This study aimed to investigate whether methadone administration lowers nociceptive threshold in adult male Sprague-Dawley (SD) rats, and if this threshold could be altered by the NMDA receptor antagonist memantine. Rats were i...

journal_title：European journal of pharmacology

authors： Hay JL,Kaboutari J,White JM,Salem A,Irvine R

更新日期：2010-01-25 00:00:00

abstract：:The suppressing effect of acamprosate (calcium-acetyl homotaurinate) on alcohol drinking is well established; however, little is known about its effects upon the alcohol-induced withdrawal syndrome. Male Wistar rats received as a sole drinking fluid a 20% (v/v) alcohol solution for one week. Animals consumed on averag...

journal_title：European journal of pharmacology

authors： Spanagel R,Putzke J,Stefferl A,Schöbitz B,Zieglgänsberger W

更新日期：1996-06-03 00:00:00

abstract：:The pharmacological profile of YM358, 2,7-diethyl-5-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]tri azole potassium salt monohydrate, a novel non-peptide angiotensin AT1 receptor antagonist, was studied in vitro and in vivo. YM358 competed with [125I][Sar1, Ile8]angiotensin II for angiotensi...

journal_title：European journal of pharmacology

authors： Shibasaki M,Fujimori A,Takanashi M,Kusayama T,Tokioka T,Satoh Y,Okazaki T,Uchida W,Inagaki O,Yanagisawa I

更新日期：1997-09-24 00:00:00

abstract：:The present studies were carried out to analyze the neurochemical and behavioral effects of peripheral sigma ligand administration in the rat. Based upon previous studies which showed an increase in turning behavior following unilateral intranigral administration of sigma ligands, we determined the effects of two sigm...

journal_title：European journal of pharmacology

authors： Patrick SL,Walker JM,Perkel JM,Lockwood M,Patrick RL

更新日期：1993-02-09 00:00:00

abstract：:Dapagliflozin (DAPA) or canagliflozin (CANA), Na+-dependent glucose co-transporter type 2 (SGLT2) inhibitors, were used for treatment of type II diabetes mellitus. Addition of DAPA or CANA suppressed M-type K+ current (IK(M)) in pituitary tumor (GH3) and pheochromocytoma PC12 cells. The IC50 value for DAPA- or CANA-me...

journal_title：European journal of pharmacology

authors： So EC,Liu PY,Wu SN

更新日期：2020-07-15 00:00:00

abstract：:Vagal motor outflow from the dorsal vagal complex is important in the regulation of intestinal motility. The aim of our study was to test the hypothesis that within the dorsal vagal complex, tonic GABA(A)-receptor mediated neurotransmission modulates intestinal motility. The GABA(A) receptor antagonist, bicuculline (m...

journal_title：European journal of pharmacology

authors： Greenwood-Van Meerveld B,Barron KW

更新日期：1998-04-10 00:00:00

abstract：:The toxicity of glutamate in neuronal cultures has been attributed in part to a mitochondrial dysfunction involving the permeability transition pore. The participation of the permeability transition pore in this process has been pharmacologically demonstrated by the use of cyclosporin A, which inhibits pore opening by...

journal_title：European journal of pharmacology

authors： Ruiz F,Alvarez G,Ramos M,Hernández M,Bogónez E,Satrústegui J

更新日期：2000-09-15 00:00:00

abstract：:The novel antiepileptic and neuroprotective drug felbamate (1 mM) caused a marked inhibition of voltage-dependent Na+ currents expressed in Xenopus oocytes upon injection of the cRNA encoding alpha-subunits from rat and human brain. This inhibition was present only if felbamate was perfused on the intracellular side o...

journal_title：European journal of pharmacology

authors： Taglialatela M,Ongini E,Brown AM,Di Renzo G,Annunziato L

更新日期：1996-12-05 00:00:00

abstract：:Endogenous inhibitory controls were studied in the spinal nerve ligation model of neuropathic pain. Atipamezole, a selective alpha2-adrenoceptor antagonist, produced both mechanical and cold allodynia in those rats which had not developed clear neuropathic symptoms. The same doses (50 microg i.t. or 1 mg/kg s.c.) did ...

journal_title：European journal of pharmacology

authors： Xu M,Kontinen VK,Kalso E

更新日期：1999-01-29 00:00:00

abstract：:Notoginsenoside R1, a unique constituent from the root of Panax notoginseng, exerts anti-inflammatory, anti-oxidative and anti-apoptotic properties. The purpose of this study was to assess the contribution of the anti-inflammatory effects of R1 to the amelioration of isoproterenol (ISO)-induced hypertrophied hearts of...

journal_title：European journal of pharmacology

authors： Xiao J,Zhu T,Yin YZ,Sun B

更新日期：2018-08-15 00:00:00

abstract：:Nerve growth factor (NGF) is known to regulate the development and survival of select populations of neurons via its binding/activation of the TrkA and p75(NTR) receptors. However, in some physiological circumstances NGF dysregulation can result in debilitating pathologies, including diabetic neuropathies, interstitia...

journal_title：European journal of pharmacology

authors： Eibl JK,Strasser BC,Ross GM

更新日期：2013-05-15 00:00:00

abstract：:The main purpose of this study was to compare in vitro pharmacological properties of human αCGRP (CGRP) and a recently discovered metabolically stable CGRP analogue, SAX, in isolated rat and human artery segments. In rat, CGRP and SAX induced similar vasodilatory responses in isolated mesenteric artery with the potenc...

journal_title：European journal of pharmacology

authors： Sheykhzade M,Abdolalizadeh B,Koole C,Pickering DS,Dreisig K,Johansson SE,Abboud BK,Dreier R,Berg JO,Jeppesen JL,Sexton PM,Edvinsson L,Wootten D,Sams A

更新日期：2018-06-15 00:00:00

abstract：:Atropine-induced locomotor stimulation was investigated in the developing rat pretreated with 6-hydroxydopa at birth. The locomotor stimulation by atropine was first observed on day 20 and gradually increased with age. The treatment with 6-hydroxydopa potentiated atropine-induced locomotor stimulation on days later th...

journal_title：European journal of pharmacology

authors： Nomura Y,Segawa T

更新日期：1978-08-15 00:00:00

abstract：:Dantrolene sodium (DaNa) markedly depressed the frequency of spontaneous miniature potentials at the frog neuromuscular junction. Its action is still observed at low [Ca2+]o and is little affected by temperature; its effect is not readily reversible. Theophylline antagonises the action of DaNa. DaNa prevents the stimu...

journal_title：European journal of pharmacology

authors： Statham HE,Duncan CJ

更新日期：1976-09-01 00:00:00

abstract：:In normotensive rats, we have previously demonstrated a role of brain mineralocorticoid receptors in blood pressure and renal function control. In the present study, the coordinate cardiovascular and renal effects of brain mineralocorticoid receptor blockade were examined by intracerebroventricular (i.c.v.) administra...

journal_title：European journal of pharmacology

authors： Rahmouni K,Sibug RM,De Kloet ER,Barthelmebs M,Grima M,Imbs JL,De Jong W

更新日期：2002-02-02 00:00:00

abstract：:Characteristics of muscarinic receptors were investigated in circular muscle from normal human colon. In saturation studies (n=18), binding of [3H]quinuclidinyl benzylate (QNB) was of high affinity (K(d) 87.3 pM) and capacity (B(max) 362+/-27 fmol/mg protein), with no differences between ascending and sigmoid colon. K...

journal_title：European journal of pharmacology

authors： Mansfield KJ,Mitchelson FJ,Moore KH,Burcher E

更新日期：2003-12-15 00:00:00

abstract：:The effect of dimethyl sulfoxide (DMSO) on the slow ventral root potential, which is related to nociceptive transmission, was investigated in the isolated spinal cord of a newborn rat. DMSO at 0.3-1% (v/v) enhanced the slow ventral root potential, but not mono- and polysynaptic reflex discharges. DMSO at 1% also enhan...

journal_title：European journal of pharmacology

authors： Kubota K,Fujibayashi K,Saito K

更新日期：1998-06-19 00:00:00

abstract：:This study was designed to investigate the effect and mechanism of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction in rats. Fifty male Wistar rats were randomly divided into five groups: the normal control rats (NC), the high-methionine-diet rats (Met), the high-methionine-diet ra...

journal_title：European journal of pharmacology

authors： Liu DS,Gao W,Liang ES,Wang SL,Lin WW,Zhang WD,Jia Q,Guo RC,Zhang JD

更新日期：2013-08-15 00:00:00

abstract：:Dihydralazine (0.1 mg/kg), injected intravenously into male Sprague-Dawley rats, caused a decrease in mean arterial blood pressure and an increase in renal plasma flow, while urine volume remained unchanged. Dihydralazine had no effect on kallikrein excretion in the urine and on kallikrein activity in the renal cortex...

journal_title：European journal of pharmacology

authors： Bönner G,Beck D,Deeg M,Marin-Grez M,Gross F

更新日期：1982-02-26 00:00:00

abstract：:The interference of azelastine with pleurisy induced by antigen was investigated in actively sensitized rats. The antigenic challenge (ovalbumin, 12 micrograms/cavity) caused early plasma leakage, which peaked within 4 h, accompanied by intense neutrophil infiltration. Pleural exudate decayed 24 h after antigen provoc...

journal_title：European journal of pharmacology

authors： Lima MC,Martins MA,Perez SA,Silva PM,Cordeiro RS,Vargaftig BB

更新日期：1991-05-17 00:00:00

abstract：:The uptake and release of 3H-dopamine was studied in slices of corpus striatum and substantia nigra in the presence of nialamide. High potassium triggered the outflow of tritium in both brain structures and this release was potentiated by GABA in a dose related fashion, whereas the spontaneous overflow of radioactivit...

journal_title：European journal of pharmacology

authors： Starr MS

更新日期：1979-01-15 00:00:00