Increases in rat striatal extracellular dopamine and vacuous chewing produced by two sigma receptor ligands.

Abstract:

:The present studies were carried out to analyze the neurochemical and behavioral effects of peripheral sigma ligand administration in the rat. Based upon previous studies which showed an increase in turning behavior following unilateral intranigral administration of sigma ligands, we determined the effects of two sigma ligands, 1,3-di-o-tolylguanidine (DTG) and (+)-pentazocine, on extracellular dopamine levels in the rat striatum. Dopamine levels were monitored via microdialysis in awake freely moving animals following i.p. injection of the ligands. Both DTG (1 and 3 mg/kg) and (+)-pentazocine (10 mg/kg) produced a significant (30-50%) increase in extracellular dopamine. Given the relatively high concentration of sigma receptors in brain nuclei involved in facial and mouth movements, we have also determined the effects of the two sigma ligands on facial movements. Both ligands produced a significant increase in vacuous chewing movements, suggesting that studies on the consequences of sigma receptor activation may have relevance to animal models of human dystonia and/or dyskinesia.

journal_name

Eur J Pharmacol

authors

Patrick SL,Walker JM,Perkel JM,Lockwood M,Patrick RL

doi

10.1016/0014-2999(93)90456-r

subject

Has Abstract

pub_date

1993-02-09 00:00:00

pages

243-9

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(93)90456-R

journal_volume

231

pub_type

杂志文章
  • PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na⁺/Ca²⁺ exchanger in guinea pig airway smooth muscle.

    abstract::The Na(+)/Ca(2+)exchanger (NCX) principal function is taking 1 Ca(2+) out of the cytoplasm and introducing 3 Na(+). The increase of cytoplasmic Na(+) concentration induces the NCX reverse mode (NCX(REV)), favoring Ca(2+) influx. NCX(REV) can be inhibited by: KB-R7943 a non-specific compound that blocks voltage-depende...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2011.11.018

    authors: Flores-Soto E,Reyes-García J,Sommer B,Chavez J,Barajas-López C,Montaño LM

    更新日期:2012-01-15 00:00:00

  • Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries.

    abstract::Although the vasorelaxant effects of taurine have been studied in rabbit ear artery, rat isolated aorta and mesenteric artery, its pharmacological properties in other vascular beds and underlying mechanism(s) are still not well clarified. The present study was designed to observe the effects of taurine on the contract...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2007.10.039

    authors: Niu LG,Zhang MS,Liu Y,Xue WX,Liu DB,Zhang J,Liang YQ

    更新日期:2008-02-02 00:00:00

  • Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models.

    abstract::Stearoyl-CoA Desaturase 1 (SCD1) is a central enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. SCD1 is an emerging target in obesity and insulin resistance due to the improved metabolic profile obtained when the enzyme is genetically inactivated. Here, we have investiga...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2009.07.004

    authors: Issandou M,Bouillot A,Brusq JM,Forest MC,Grillot D,Guillard R,Martin S,Michiels C,Sulpice T,Daugan A

    更新日期:2009-09-15 00:00:00

  • Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig.

    abstract::In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 microgram/kg); the maximum effect was obtained with 1.0 microgram/kg which doubled the bronchoconstriction. When the dose was increased abov...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(87)90251-2

    authors: Fryer AD,Maclagan J

    更新日期:1987-07-09 00:00:00

  • Inhibitory effect of various thrombin inhibitors on shear-induced platelet function and dynamic coagulation.

    abstract::We assessed the effects of active site-directed, fibrinogen recognition exosite (FRE)-directed and bifunctional thrombin inhibitors, on shear-induced platelet reactivity (adhesion/aggregation) and dynamic coagulation (coagulation of flowing blood). An in vitro test for shear-induced haemostatic plug formation and dyna...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(00)00655-5

    authors: Taka T,Konishi Y,Slon-Usakiewicz J,Medvedkin V,Tsuda Y,Okada Y,Seki J,Yamamoto J

    更新日期:2000-10-13 00:00:00

  • Lithium treatment decreases blood pressure in genetically hypertensive rats.

    abstract::Chronic lithium treatment was examined for effects on the blood pressure of spontaneously hypertensive rats (SHRs). Treated rats were allowed continuous access to a pelleted lithium diet (1.7 g LiCl (40 mmol)/kg diet) for 21 days. Control SHRs were fed a similar diet lacking the lithium. Two groups of control rats wer...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(81)90112-6

    authors: Koda LY,Shoemaker WJ,Baetge G,Bloom FE

    更新日期:1981-12-17 00:00:00

  • Modulation of nicotine self-administration in rats by combination therapy with agents blocking alpha 3 beta 4 nicotinic receptors.

    abstract::18-Methoxycoronaridine, a novel iboga alkaloid congener that decreases drug self-administration in several animal models, may be a potential treatment for multiple forms of drug abuse. In previous work, 18-methoxycoronaridine was found to be a somewhat selective antagonist at alpha3beta4 nicotinic receptors; and low d...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(02)01944-1

    authors: Glick SD,Maisonneuve IM,Kitchen BA

    更新日期:2002-07-19 00:00:00

  • Inhibitors of Ca(2+)-dependent endopeptidases modulate morphine-induced effects in rats.

    abstract::The effects of inhibitors of Ca(2+)-dependent endopeptidases (antipain and leupeptin) on morphine analgesia, reinforcing properties of morphine and on the development of opiate physical dependence were studied. Male Wistar rats were used. The analgesic action of morphine in the tail-immersion test was increased signif...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(96)00092-1

    authors: Lyupina YV,Sudakov SK,Yarygin VN

    更新日期:1996-05-23 00:00:00

  • The potassium channel opener CGS7184 activates Ca²⁺ release from the endoplasmic reticulum.

    abstract::CGS7184 (ethyl 1-[[(4-chlorophenyl)amino]oxo]-2-hydroxy-6-trifluoromethyl-1H-indole-3-carboxylate) is a synthetic large-conductance Ca(2+)-activated potassium (BK(Ca)) channel opener. The existing literature suggests that potassium channels are involved in cardioprotection, particularly during ischemia-reperfusion eve...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2012.06.029

    authors: Wrzosek A,Tomaskova Z,Ondrias K,Lukasiak A,Szewczyk A

    更新日期:2012-09-05 00:00:00

  • 3-Methoxytyramine, an extraneuronal dopamine metabolite plays a physiological role in the brain as an inhibitory regulator of catecholaminergic activity.

    abstract::3-Methoxytyramine (3-MT), an extraneuronal metabolite of dopamine, present in the synaptic cleft at a very low amount (low nanomolar range), comparable to dopamine concentration, is generally regarded as a biologically inactive compound. We have shown in this study that 3-MT binds to the rat noradrenergic cortical alp...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2008.09.033

    authors: Antkiewicz-Michaluk L,Ossowska K,Romańska I,Michaluk J,Vetulani J

    更新日期:2008-12-03 00:00:00

  • In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa.

    abstract::We investigated in vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone from Saussurea lappa, on tumor necrosis factor (TNF)-alpha and nitric oxide (NO) release, and lymphocyte proliferation. Cynaropicrin strongly inhibited TNF-alpha release from lipopolysaccharide-stimulated murine macrophage, RAW...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(00)00337-x

    authors: Cho JY,Baik KU,Jung JH,Park MH

    更新日期:2000-06-23 00:00:00

  • The alpha 1-adrenoceptor is inactivated by alterations in membrane phospholipids.

    abstract::The influence of the membrane environment on the alpha 1-adrenoceptor has been investigated by examining the effect of phospholipase digestion on the binding of [3H]prazosin to aortic and hepatic membranes. Membrane digestion by phospholipase A2 and phospholipase C was found to markedly reduce prazosin binding to the ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0922-4106(92)90079-b

    authors: Shreeve SM,Valliere JE

    更新日期:1992-05-12 00:00:00

  • Effects of granisetron, a 5-HT3 receptor antagonist, on morphine-induced potentiation of brain stimulation reward.

    abstract::Using the curve-shift method, we studied the effects of four doses (0.003, 0.03, 0.3 and 3 mg/kg, s.c.) of granisetron (endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3- carboxamide hydrochloride), a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, on the potentiation of brain stimulatio...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(95)00497-1

    authors: Rompré PP,Injoyan R,Hagan JJ

    更新日期:1995-12-20 00:00:00

  • Preclinical murine models of Chronic Obstructive Pulmonary Disease.

    abstract::Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated inflammatory response to cigarette smoke causes progressive airflow limitation. This inflammation, where macrophages, neutrophils and T lymphocytes ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejphar.2015.03.029

    authors: Vlahos R,Bozinovski S

    更新日期:2015-07-15 00:00:00

  • Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors.

    abstract::The purpose of this study was to elucidate the role of human organic anion transporters (human OATs) in the induction of drug-induced skeletal muscle abnormalities. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors have been clinically used for lowering plasma cholesterol levels, and are known to in...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2003.10.017

    authors: Takeda M,Noshiro R,Onozato ML,Tojo A,Hasannejad H,Huang XL,Narikawa S,Endou H

    更新日期:2004-01-12 00:00:00

  • Amitriptyline-induced morphological alterations of the rat blood-brain barrier.

    abstract::Amitriptyline is known to increase the permeability of the blood-brain barrier but the morphological basis of this increase has not been studied. As catecholamines can influence pinocytosis in dog peripheral blood vessels, the effect of amitriptyline on the pinocytotic activity of blood brain microvessels was studied....

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(90)90133-q

    authors: Sarmento A,Albino-Teixeira A,Azevedo I

    更新日期:1990-01-25 00:00:00

  • Isolated human bladder: evidence for an adenine dinucleotide acting on P2X-purinoceptors and for purinergic transmission.

    abstract::In isolated strips of human urinary bladder detrusor muscle, ATP, alpha, beta-methylene ATP and P1,P6-diadenosine hexaphosphate caused concentration-dependent contractions. ATP was less potent than the two synthetic purine compounds and gave smaller maximum responses. Responses to ATP, P1,P6-diadenosine hexaphosphate ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(89)90881-9

    authors: Hoyle CH,Chapple C,Burnstock G

    更新日期:1989-12-12 00:00:00

  • Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells.

    abstract::Several antimalarial drugs are known to produce a QT interval prolongation via a blockade of the rapidly activating delayed rectifier K+ current (IKr), encoded by the human-ether-a-go-go-related gene (hERG). We investigated the influence of lumefantrine and its major metabolite desbutyl-lumefantrine, as well as halofa...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2003.11.003

    authors: Traebert M,Dumotier B,Meister L,Hoffmann P,Dominguez-Estevez M,Suter W

    更新日期:2004-01-19 00:00:00

  • Infusion of D-cycloserine into temporal-hippocampal areas and restoration of mnemonic function in rats with disrupted glutamatergic temporal systems.

    abstract::Partial transections of the fiber connections between the temporal cortex and the lateral entorhinal cortex at a site of the white matter corresponding to the perirhinal cortex result in impaired visual memory accompanied by reduced concentrations of glutamate in both the temporal cortex and lateral entorhinal cortex....

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(97)83019-1

    authors: Myhrer T,Paulsen RE

    更新日期:1997-06-05 00:00:00

  • Binary combinations of propofol and barbiturates on human alpha(1) glycine receptors expressed in Xenopus oocytes.

    abstract::To test whether there is a common site of action for intravenous anaesthetics at the glycine receptor, the effects of binary combinations of thiopentone, pentobarbitone, methohexitone, and propofol have been tested on human alpha(1) glycine receptors expressed in Xenopus laevis oocytes using two-electrode voltage-clam...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2003.08.017

    authors: Hadipour-Jahromy M,Daniels S

    更新日期:2003-09-12 00:00:00

  • Enhancement of brain kynurenic acid production by anticonvulsants--novel mechanism of antiepileptic activity?

    abstract::In this study, we describe the effect of antiepileptic drugs on the production of kynurenic acid in rat cortical slices, and on the activity of kynurenic acid biosynthetic enzymes, kynurenine aminotransferases (KATs I and II) in the brain tissue. Phenobarbital, felbamate, phenytoin and lamotrigine (all at 0.5-3.0 mM) ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2006.05.015

    authors: Kocki T,Wielosz M,Turski WA,Urbanska EM

    更新日期:2006-07-17 00:00:00

  • Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect.

    abstract::Prolactin blood level and apomorphine-induced yawning were studied in rats treated with the substituted benzamide amisulpride in association with bromocriptine or carmoxirole; two dopamine D(2) receptor agonists with high or low propensity to cross the brain-blood barrier, respectively. Administration of amisulpride p...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(02)01896-4

    authors: Marchese G,Ruiu S,Casti P,Bartholini F,Saba P,Gessa GL,Pani L

    更新日期:2002-06-28 00:00:00

  • Behavioural topography in the striatum: differential effects of quinpirole and D-amphetamine microinjections.

    abstract::Behavioural evidence has accumulated that supports the hypothesis that specific territories of the striatum contribute differentially to the control of motor behaviours. The present experiments compare the behavioural effects of microinjections of amphetamine (20 microg/0.5 microl) with those elicited by the D2-class ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/s0014-2999(98)00752-3

    authors: Canales JJ,Iversen SD

    更新日期:1998-12-04 00:00:00

  • Evidence for the presence of P1-purinoceptors on cholinergic nerve terminals in the guinea-pig ileum.

    abstract::The inhibitory effects of adenosine, ATP, 5'-adenylyl methylene diphosphonate (beta, gamma-meATP) and adenosine 5'-alpha, beta-methylene triphosphonate (alpha, beta-meATP) were compared on the cholinergic twitch responses to transmural stimulation of the guinea-pig ileum. Adenosine, ATP and beta, gamma-meATP reduced t...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(82)90527-1

    authors: Moody CJ,Burnstock G

    更新日期:1982-01-08 00:00:00

  • Midcervical vagotomy precludes respiratory response to novel anti-inflammatory and anti-tumour drug arvanil in rats.

    abstract::Arvanil is a metabolically stable hybrid between anandamide and capsaicin. The present study was designed to test the role of the vagal pathway in post-arvanil respiratory and blood pressure responses. Respiratory and pressure changes evoked by an intravenous injection of arvanil were investigated in 21 urethane-chlor...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2010.06.012

    authors: Kopczyńska B

    更新日期:2010-09-15 00:00:00

  • Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif.

    abstract::The molecular mechanisms regulating the trafficking of the CRTH2 receptor are poorly understood. In the present study, we characterize C-terminal tail determinants involved in the agonist-induced trafficking of the CRTH2 receptor for prostaglandin D(2). Our results showed that progressive deletion of C-terminal tail r...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2009.12.022

    authors: Roy SJ,Parent A,Gallant MA,de Brum-Fernandes AJ,Stanková J,Parent JL

    更新日期:2010-03-25 00:00:00

  • Norbinaltorphimine: antagonist profile at kappa opioid receptors.

    abstract::The pharmacological profile of the opioid antagonist norbinaltorphimine has been characterised in vitro and in vivo. In vitro, norbinaltorphimine reversibly antagonised the effects of kappa agonists with pA2 values of 10.2-10.4. Norbinaltorphimine was much less potent as an antagonist at mu and delta receptors, pA2 va...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(87)90397-9

    authors: Birch PJ,Hayes AG,Sheehan MJ,Tyers MB

    更新日期:1987-12-15 00:00:00

  • Effect of NZ-107 on late-phase airway responses and airway hyperreactivity in guinea pigs.

    abstract::The effect of NZ-107 (4-bromo-5-(3-ethoxy-4-methoxybenzylamino)-3(2H)-pyridazinone) on late-phase airway responses and airway hyperreactivity was investigated in the guinea pig. Challenge with inhaled ovalbumin in conscious guinea pigs actively sensitized with inhaled ovalbumin caused triphasic bronchial obstruction, ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(91)90490-h

    authors: Iwama T,Shikada K,Yamamoto A,Sakashita M,Hibi M,Tanaka S

    更新日期:1991-07-09 00:00:00

  • Baroreceptor-induced decrease in muscle blood flow upon propranolol administration.

    abstract::The acute effects of propranolol, 1 mg/kg i.v., were studied in chloralosed, vagotomized cats. The vascularly isolated but innervated calf muscles were perfused from another animal. In one group of experiments, the carotid baroreceptors were exposed to ambient arterial pressure. Here, propranolol caused a fall in hear...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/0014-2999(78)90361-8

    authors: Lisander B,Nilsson H

    更新日期:1978-08-01 00:00:00

  • Behavioral sensitization to the discriminative stimulus effects of methamphetamine in rats.

    abstract::Sensitization to the discriminative stimulus effects of psychostimulants is not fully understood. Therefore, the present study was designed to investigate the development of sensitization to the discriminative stimulus of methamphetamine in rats. A dose-response curve for methamphetamine and a generalization test for ...

    journal_title:European journal of pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.ejphar.2004.07.064

    authors: Suzuki T,Fukuoka Y,Mori T,Miyatake M,Narita M

    更新日期:2004-09-13 00:00:00