Abstract:
:The novel antiepileptic and neuroprotective drug felbamate (1 mM) caused a marked inhibition of voltage-dependent Na+ currents expressed in Xenopus oocytes upon injection of the cRNA encoding alpha-subunits from rat and human brain. This inhibition was present only if felbamate was perfused on the intracellular side of the membrane. In addition, felbamate seems to preferentially bind to and stabilize the inactivated state of the channel, resembling the action of local anesthetics. This study provides an additional mechanism by which felbamate might exert its wide-spectrum anticonvulsant and neuroprotective action.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Taglialatela M,Ongini E,Brown AM,Di Renzo G,Annunziato Ldoi
10.1016/s0014-2999(96)00802-3subject
Has Abstractpub_date
1996-12-05 00:00:00pages
373-7issue
2-3eissn
0014-2999issn
1879-0712pii
S0014-2999(96)00802-3journal_volume
316pub_type
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