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Stereoselective inhibition of synaptosomal catecholamine uptake by nomifensine.

Abstract：

:The effects of the two enantiomers of the antidepressant nomifensine on catecholamine uptake were investigated using rat brain synaptosomes. According to the results from in vitro and ex vivo/in vitro studies, the inhibitory activity on catecholamine uptake resides entirely in the (+)-form of nomifensine. Further studies comparing the antidepressant effects of the two enantiomers might help to clarify the validity of the catecholamine hypothesis of depression.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Schacht U,Leven M

doi

10.1016/0014-2999(84)90601-0

subject

Has Abstract

pub_date

1984-02-17 00:00:00

pages

275-7

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(84)90601-0

journal_volume

98

pub_type

杂志文章

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