Abstract:
:Using isolated rabbit gastric glands, the H2-receptor antagonist MK-208 was investigated with respect to its effects on [14C]aminopyrine uptake as an index of gastric acid secretion. In addition to shifting the histamine concentration-response curve to the right in a parallel fashion, the antagonism produced by MK-208 was reversible, contrary to that previously seen in the guinea pig atria. These observations suggest that the H2-receptors responsible for mediating gastric secretion in the rabbit and the chronotropic response in guinea pig atria are different.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Shepherd-Rose AJ,Pendleton RGdoi
10.1016/0014-2999(84)90733-7subject
Has Abstractpub_date
1984-11-13 00:00:00pages
423-6issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(84)90733-7journal_volume
106pub_type
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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