Abstract:
:Acute (-)-nicotine administration (0.4 and 0.8 mg/kg s.c.) produced a regionally specific increase in the rate of catecholamine synthesis in the rat nucleus accumbens, hypothalamus and hippocampus but not elsewhere, including the caudate-putamen. In all regions rates of 5-hydroxytryptamine synthesis were unaffected. (-)-Cotinine (0.4 and 0.8 mg/kg), the major metabolite of (-)-nicotine was without effect. (-)-Nicotine-induced increase in catecholamine synthesis occurred by a direct stimulation of central nicotinic receptors, as mecamylamine (5 mg/kg) but not hexamethonium (5 mg/kg) was an effective antagonist. Following repeated daily injections of (-)-nicotine (0.8 mg/kg) for up to 28 days, the induced catecholamine response following a subsequent challenge was unaffected in the nucleus accumbens and hypothalamus, but was increased in the hippocampus. This effect persisted for up to 14 days following withdrawal. Rates of 5-hydroxytryptamine synthesis remained unaltered after chronic pretreatment.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Mitchell SN,Brazell MP,Joseph MH,Alavijeh MS,Gray JAdoi
10.1016/0014-2999(89)90440-8subject
Has Abstractpub_date
1989-08-29 00:00:00pages
311-22issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(89)90440-8journal_volume
167pub_type
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journal_title:European journal of pharmacology
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