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Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1.

Abstract：

:It has been reported that icariin protects neurons against ischemia/reperfusion injury. In this study, we found that icariin could enhance neuronal viability and suppress neuronal death after oxygen and glucose deprivation (OGD). Further study showed that neuroprotection by icariin was through the induction of Sirtuin type 1 (SIRT1), an effect that was reversed by SIRT1 inhibitor III and P38 inhibitor SB203580. SIRT1 is an endogenous gene of longevity, which increased neuronal viability and could be activated by stimulating the mitogen-activated protein kinase (MAPK) pathway. However, this study found that icariin activated the MAPK/P38 pathway, not the extracellular signal-regulated kinase (MAPK/ERK) or c-Jun N-terminal protein kinase (MAPK/JNK) to regulate SIRT1 expression. The results suggest that icariin may be developed into a neuroprotectant for ischemia-related brain injury.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Wang L,Zhang L,Chen ZB,Wu JY,Zhang X,Xu Y

doi

10.1016/j.ejphar.2009.03.033

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

40-4

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(09)00249-0

journal_volume

609

pub_type

杂志文章

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