The delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [correction of 7-benzylspiroindanylnaltrexone], prolongs renal allograft survival in a rat model.

abstract：:Renal mesangial cells exposed to inflammatory cytokines produce high concentrations of nitric oxide (NO) which may exert cytotoxic actions. We report here that glomerular mesangial cells, endothelial cells and epithelial cells in culture are themselves targets for NO and undergo apoptotic cell death upon exposure to h...

journal_title：European journal of pharmacology

authors： Mühl H,Sandau K,Brüne B,Briner VA,Pfeilschifter J

更新日期：1996-12-12 00:00:00

abstract：:Opiate agonists exhibiting selectivity for mu, kappa, sigma, and delta opiate receptors were microinjected into the periaqueductal gray region (PAG) of the brain of rats to determine the receptor subtype(s) associated with the initiation of descending pain inhibition. The spinally organized, heat nociceptive tail-flic...

journal_title：European journal of pharmacology

authors： Smith DJ,Perrotti JM,Crisp T,Cabral ME,Long JT,Scalzitti JM

更新日期：1988-10-26 00:00:00

abstract：:The suppression of pro-inflammatory cytokine-induced inflammation responses is an attractive pharmacological target for the development of therapeutic strategies for inflammatory bowel disease (IBD). In the present study, we evaluated the anti-inflammatory properties of flavonoid isoliquiritigenin (ISL) in intestinal ...

journal_title：European journal of pharmacology

authors： Chi JH,Seo GS,Cheon JH,Lee SH

更新日期：2017-02-05 00:00:00

abstract：:In vitro studies have provided evidence that Cl(-) ion currents are important for activation of vascular smooth muscle contraction. The stilbene, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), disrupts Cl(-) metabolism by blocking Cl(-) channels and by inhibiting Cl(-) bicarbonate exchange. The aims of thi...

journal_title：European journal of pharmacology

authors： Lamb FS,Kooy NW,Lewis SJ

更新日期：2000-08-11 00:00:00

abstract：:It has been documented cardiac fibroblasts as the predominant cell population undergoing senescence in heart. Calcitonin gene-related peptide (CGRP) exhibits a wide range of cardiovascular protective effects. Whether CGRP protects against cardiac fibroblasts senescence in cardiac fibrosis remains unknown. Here, we det...

journal_title：European journal of pharmacology

authors： Li WQ,Tan SL,Li XH,Sun TL,Li D,Du J,Wei SS,Li YJ,Zhang BK

更新日期：2019-01-15 00:00:00

abstract：:An in vitro method was developed for the biochemical and autoradiographic demonstration of low muscarinic receptor densities in peripheral tissue. Histological criteria point clearly to the necessity for fixation to preserve tissue quality. [3H]l-Quinuclidinylbenzilate bound specifically to a homogeneous class of bind...

journal_title：European journal of pharmacology

authors： Van Megen YJ,Teunissen MJ,Klaassen AB,Rodrigues de Miranda JF

更新日期：1988-01-05 00:00:00

abstract：:Voltage-gated potassium (Kv) channels are the largest superfamily of potassium (K) channels. A variety of Kv channels are expressed in the vascular smooth muscle cells (SMC). Studies have shown that gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) cause various changes in the human umbilica...

journal_title：European journal of pharmacology

authors： Djokic V,Jankovic S,Labudovic-Borovic M,Rakocevic J,Stanisic J,Rajkovic J,Novakovic R,Kostic M,Djuric M,Gostimirovic M,Gojkovic-Bukarica L

更新日期：2020-09-05 00:00:00

abstract：:Earlier studies demonstrated that cytokine production is under the tonic control of noradrenaline. As the level and/or the duration of noradrenaline action is regulated by the noradrenaline transporter (NET), which is also a target of antidepressant treatment, we studied its role in the regulation of the cytokine resp...

journal_title：European journal of pharmacology

authors： Selmeczy Z,Szelényi J,Vizi ES

更新日期：2003-05-23 00:00:00

abstract：:The influence of decreased endogenous gamma-aminobutyric acid (GABA) concentration on benzodiazepine receptor function was studied in the brain of living baboons. Positron emission tomography and the radiotracer [11C]flumazenil combined with electroencephalography were used to determine the pharmacological properties ...

journal_title：European journal of pharmacology

authors： Bottlaender M,Schmid L,Fuseau C,Fournier D,Brouillet E,Mazière M

更新日期：1997-02-19 00:00:00

abstract：:The concentration of blood glucose was measured in rats after administration of a number of drugs characterized as dopamine agonists. Compounds that cause release of dopamine, or agents that block the reuptake of dopamine, did not elevate blood glucose. Some direct dopamine receptor stimulants (lergotrile, bromocripti...

journal_title：European journal of pharmacology

authors： Schmidt MJ,Root MA,Hall JL

更新日期：1983-06-03 00:00:00

abstract：:The acute effects of propranolol, 1 mg/kg i.v., were studied in chloralosed, vagotomized cats. The vascularly isolated but innervated calf muscles were perfused from another animal. In one group of experiments, the carotid baroreceptors were exposed to ambient arterial pressure. Here, propranolol caused a fall in hear...

journal_title：European journal of pharmacology

authors： Lisander B,Nilsson H

更新日期：1978-08-01 00:00:00

abstract：:In the present report, we used [3H]idazoxan to characterize imidazoline-guanidinium receptive sites (IGRS) in mitochondria from rabbit cerebral cortex. When compared to the starting homogenate, [3H]idazoxan binding was higher (1.161 +/- 0.159 vs. 0.102 +/- 0.024 pmol/mg of protein) in a membrane fraction 6-fold enrich...

journal_title：European journal of pharmacology

authors： Tesson F,Parini A

更新日期：1991-09-12 00:00:00

abstract：:gamma-Aminobutyric acid B (GABA(B)) receptor is the first discovered G protein-coupled receptor that requires two subunits, GB1 and GB2, to form a functional receptor. Whereas the molecular and functional characteristics of GABA(B) receptors have been recently extensively studied, the mechanisms underlying receptor de...

journal_title：European journal of pharmacology

authors： González-Maeso J,Wise A,Green A,Koenig JA

更新日期：2003-11-14 00:00:00

abstract：:With some latency, ouabain (10(-6)--10(-5) M) induced a long-lasting contractile response of the isolated vas deferens of the guinea-pig. The ouabain-induced contraction was potentiated by pretreatment with tropolone, whereas it was prevented by pretreatment with cocaine, bretylium, reserpine or phentolamine. The resp...

journal_title：European journal of pharmacology

authors： Katsuragi T,Fukushi Y,Suzuki T

更新日期：1978-02-15 00:00:00

abstract：:The in vitro biological characterisation of the first potent and selective non-peptide neuropeptide Y Y(2) receptor antagonist, (S)-N(2)-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b, e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl] cylopentyl] acetyl]-N-[2-[1,2-dihydro-3,5(4H)-dioxo-1,2-diphenyl-3H-1,2, 4-triazol-4-yl]et...

journal_title：European journal of pharmacology

authors： Doods H,Gaida W,Wieland HA,Dollinger H,Schnorrenberg G,Esser F,Engel W,Eberlein W,Rudolf K

更新日期：1999-11-19 00:00:00

abstract：:Lung cancer is a disease with increasing morbidity worldwide in recent years. Approaches such as chemotherapy and biological targeting for its treatment are urgently needed. Epithelial-mesenchymal transition (EMT) is an important initiation stage for tumor cells to acquire invasive and metastatic abilities. Increasing...

journal_title：European journal of pharmacology

authors： Guo L,Liu Z,Tang X

更新日期：2019-11-05 00:00:00

abstract：:Rat hearts were perfused at 37 degrees C with three clearly-defined protocols: the Ca2+ paradox, the O2 paradox and with 20 mM caffeine. Each protocol involved an initial priming (stage 1) and a subsequent full activation (stage 2) of the damage system of the sarcolemma. Raising [K+]o from 5.4 to 6.5 mM in the Ca2+ pa...

journal_title：European journal of pharmacology

authors： Harding RJ,Duncan CJ

更新日期：1996-12-05 00:00:00

abstract：:The effects of two predominant dopamine D2-like receptor agonists, talipexole (6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo [4,5-d]-azepine dihydrochloride, B-HT 920 CL2) and pramipexole (S(-)2-amino-4,5,6,7-tetrahydro-6-propyl-aminobenzothiazole dihydrochloride, SND 919 CL2Y), were studied alone and in combination ...

journal_title：European journal of pharmacology

authors： Domino EF,Ni L,Zhang H,Kohno Y,Sasa M

更新日期：1997-05-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of intracavernosal injections of adrenomedullin, a novel hypotensive peptide, on penile erection in anesthetized cats. Responses to adrenomedullin were compared to those elicited by intracavernosal injection of the control triple-drug combination (1.65 mg pap...

journal_title：European journal of pharmacology

authors： Champion HC,Wang R,Shenassa BB,Murphy WA,Coy DH,Hellstrom WJ,Kadowitz PJ

更新日期：1997-01-14 00:00:00

abstract：:The effects of paeoniflorin, a glycoside isolated from the root of Paeonia lactiflora, on ion currents in a mouse neuroblastoma and rat glioma hybrid cell line, NG108-15 were investigated. Paeoniflorin (1-300 microM) reversibly produced an inhibition of L-type voltage-dependent Ca2+ current (I(Ca,L)) in a concentratio...

journal_title：European journal of pharmacology

authors： Tsai TY,Wu SN,Liu YC,Wu AZ,Tsai YC

更新日期：2005-10-31 00:00:00

abstract：:The effects of a single dose of naloxone and of [D-Met2,Pro5]enkephalinamide on the DNA synthesis in the uterus of 7, 14 and 21-day-old rat were studied. After [D-Met2,Pro5]enkephalinamide treatment, an age-dependent decrease in in vitro [3H]thymidine incorporation into DNA was observed in all studied age groups. In t...

journal_title：European journal of pharmacology

authors： Vértes Z,Környei JL,Kovács S,Vértes M

更新日期：1995-10-15 00:00:00

abstract：:It has been suggested that administration of a cannabinoid CB(1) (SR141716A ¿N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1-H-pyrazole-3-carboxamide) and CB(2) (SR144528 ¿N-[(1S)-endo-1, 3, 3-trimethyl bicyclo ¿2.2.1 heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyr azo le- 3-ca...

journal_title：European journal of pharmacology

authors： Beaulieu1 P,Bisogno1 T,Punwar S,Farquhar-Smith WP,Ambrosino G,Di Marzo V,Rice AS

更新日期：2000-05-19 00:00:00

abstract：:A substantial proportion of depressed patients do not respond to current antidepressant drug therapies. So far, antidepressant drugs have been developed based on the "monoaminergic hypothesis" of depression, which considers a synaptic deficiency in 5-hydroxytryptamine (5-HT; serotonin) or noradrenaline as main cause. ...

journal_title：European journal of pharmacology

authors： Leggio GM,Salomone S,Bucolo C,Platania C,Micale V,Caraci F,Drago F

更新日期：2013-11-05 00:00:00

abstract：:Prazosin is believed to have an antihypertensive action due to a selective blockade of alpha-adrenoceptors on vascular smooth muscle. Using an in vitro autoradiographic technique specific binding of [3H]prazosin to the abdominal aorta and renal artery in the rat has been shown. The binding of [3H]prazosin to arterial ...

journal_title：European journal of pharmacology

authors： Dashwood M,Bagnall J

更新日期：1982-02-19 00:00:00

abstract：:Trans-dehydrocrotonin has antiulcerogenic and antitumor activities. A complex of beta-cyclodextrin with dehydrocrotonin was developed to improve the delivery of dehydrocrotonin. Complex in solid state was evaluated using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TG...

journal_title：European journal of pharmacology

authors： Corrêa DH,Melo PS,de Carvalho CA,de Azevedo MB,Durán N,Haun M

更新日期：2005-03-07 00:00:00

abstract：:Geniposide (GE) can effectively inhibit diabetic nephropathy (DN), but its mechanism is unclear. The objective of this study was to explore the antidiabetic nephropathy effects of GE both in high fat diet/streptozotocin-induced DN mice and in high glucose-induced podocyte model. Renal function in DN mice was evaluated...

journal_title：European journal of pharmacology

authors： Li F,Chen Y,Li Y,Huang M,Zhao W

更新日期：2020-11-05 00:00:00

abstract：:The aim of the present investigation was to assess neuroprotection exerted by diazepam (0.1-25 microM) in rat cortical brain slices subjected to oxygen-glucose deprivation and reoxygenation. Neuronal injury and neuroprotection were assessed by measuring the release of glutamate and lactate dehydrogenase and tissue wat...

journal_title：European journal of pharmacology

authors： Ricci L,Valoti M,Sgaragli G,Frosini M

更新日期：2007-04-30 00:00:00

abstract：:The nerve growth factor (NGF) is a neurotrophic factor essential for the development and survival of neurons. It has also been identified as a mediator of inflammation and can cause airway hyperresponsiveness [Frossard et al., Eur. J. Pharmacol. 500, 453 (2004)]. Evidence in rodents suggests a link between tachykinins...

journal_title：European journal of pharmacology

authors： Naline E,Höglund CO,Vincent F,Emonds-Alt X,Lagente V,Advenier C,Frossard N

更新日期：2007-04-10 00:00:00

abstract：:Intrinsic drug resistance occurs in many renal carcinomas and is associated with increased expression of multidrug resistant proteins, which inhibits intracellular drug accumulation. Multidrug resistant protein 1, also known as P-glycoprotein, is a membrane drug efflux pump belonging to the ATP-binding cassette (ABC) ...

journal_title：European journal of pharmacology

authors： Sato H,Siddig S,Uzu M,Suzuki S,Nomura Y,Kashiba T,Gushimiyagi K,Sekine Y,Uehara T,Arano Y,Yamaura K,Ueno K

更新日期：2015-01-05 00:00:00

abstract：:The role of tuberoinfundibular and periventricular-hypophysial dopaminergic neurons in mediating rimcazole-induced decreases in plasma concentrations of prolactin and alpha-melanocyte stimulating hormone was assessed. Dopaminergic neuronal activity was estimated by measuring concentrations of 3,4-dihydroxyphenylacetic...

journal_title：European journal of pharmacology

authors： Eaton MJ,Lookingland KJ,Moore KE

更新日期：1996-03-28 00:00:00