Abstract:
:The acute effects of propranolol, 1 mg/kg i.v., were studied in chloralosed, vagotomized cats. The vascularly isolated but innervated calf muscles were perfused from another animal. In one group of experiments, the carotid baroreceptors were exposed to ambient arterial pressure. Here, propranolol caused a fall in heart rate and an increase in resistance of the isolated muscle bed. In other experiments, the carotid sinuses were perfused at a constant pressure. In these animals, no increase in muscle flow resistance was observed after the drug. It is concluded that the increase in total peripheral resistance, seen initially upon propranolol administration, may be reflexly induced via the baroreceptors.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Lisander B,Nilsson Hdoi
10.1016/0014-2999(78)90361-8subject
Has Abstractpub_date
1978-08-01 00:00:00pages
275-8issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(78)90361-8journal_volume
50pub_type
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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