Identification of an imidazoline-guanidinium receptive site in mitochondria from rabbit cerebral cortex.

abstract：:Endogenous opioid and nociceptin systems are widely distributed in the gastrointestinal tract where they seem to play a crucial role in maintaining the intestinal homeostasis. The aim of our study was to assess whether activation of nociceptin (NOP) and µ-opioid (MOP) receptors by a mixed NOP/MOP receptor agonist, BU0...

journal_title：European journal of pharmacology

authors： Zielińska M,Ben Haddou T,Cami-Kobeci G,Sałaga M,Jarmuż A,Padysz M,Kordek R,Spetea M,Husbands SM,Fichna J

更新日期：2015-10-15 00:00:00

abstract：:UP 269-6, 5-methyl-7-propyl-8(-)[2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]-1,2,4-triazolo]1,5-c]pyrimidin-2(3H)-one is a novel nonpeptide angiotensin II receptor antagonist. In vivo studies were performed to evaluate UP 269-6 for its angiotensin II antagonistic action. In pithed rats, i.v. administration of UP 269-6...

journal_title：European journal of pharmacology

authors： Cazes M,Provost D,Versigny A,Cloarec A

更新日期：1995-09-15 00:00:00

abstract：:Imipramine and mianserin are equipotent inhibitors of noradrenaline (NA) uptake in synaptosomes. However, after in vivo administration, NA uptake was inhibited only in synaptosomes from imipramine-treated rats, suggesting that imipramine, or its metabolite desipramine, binds to the NA carrier in a manner outlasting th...

journal_title：European journal of pharmacology

authors： Raiteri M,Del Carmine R,Cervoni AM,Levi G

更新日期：1979-08-15 00:00:00

abstract：:The beta-carboline FG7142 is a partial inverse agonist at benzodiazepine receptors. We have shown previously that a single dose of this drug causes an upregulation of cortical beta-adrenoceptor numbers in mouse cerebral cortex. This rise was seen seven days, but not 15-30 min or 24 h after FG7142 administration. We no...

journal_title：European journal of pharmacology

authors： Stanford SC,Taylor SC,Little HJ

更新日期：1987-07-09 00:00:00

abstract：:Coronary artery disease (CAD) is the most common cause of sudden death, and death of people over 20 years of age. Because ozone therapy can activate the antioxidant system and improve blood circulation and oxygen delivery to tissue, the aim of this study was to investigate the therapeutic efficacy of ozone in patients...

journal_title：European journal of pharmacology

authors： Martínez-Sánchez G,Delgado-Roche L,Díaz-Batista A,Pérez-Davison G,Re L

更新日期：2012-09-15 00:00:00

abstract：:The pharmacological profile of (+/-)-domesticine, a novel alpha(1)-adrenoceptor antagonist, was examined in animal tissues and Chinese hamster ovary (CHO) cells expressing cloned human alpha(1)-adrenoceptor subtypes and compared with the properties of BMY-7378 ([8-(2-[4-(2-methoxy-phenyl)-1-piperazinyl]ethyl)-8-azaspi...

journal_title：European journal of pharmacology

authors： Indra B,Matsunaga K,Hoshino O,Suzuki M,Ogasawara H,Muramatsu I,Taniguchi T,Ohizumi Y

更新日期：2002-06-07 00:00:00

abstract：:Platelet aggregation induced in mice or rats by i.v. ADP can be antagonized by oral administration of suloctidil. This effect on platelet behaviour appears to be sufficient to reduce the rate of thrombotic occlusion of the femoral artery in the dog and to protect the rat against occurrence of thrombophlebitis. ...

journal_title：European journal of pharmacology

authors： Roba J,Claeys M,Lambelin G

更新日期：1976-06-01 00:00:00

abstract：:It has been reported that icariin protects neurons against ischemia/reperfusion injury. In this study, we found that icariin could enhance neuronal viability and suppress neuronal death after oxygen and glucose deprivation (OGD). Further study showed that neuroprotection by icariin was through the induction of Sirtuin...

journal_title：European journal of pharmacology

authors： Wang L,Zhang L,Chen ZB,Wu JY,Zhang X,Xu Y

更新日期：2009-05-01 00:00:00

abstract：:The effects of hyperosmotic solutions of xylitol were tested on acid and bicarbonate outputs from the rat stomach as well as on acid back-diffusion. Hyperosmotic solutions were instilled into anesthetized rats by an esophageal cannula and drained through a duodenal catheter. Spontaneously secreting and histamine-stimu...

journal_title：European journal of pharmacology

authors： Assouline G,Danon A

更新日期：1984-07-13 00:00:00

abstract：:Resveratrol has been purported to modify risk factors for obesity and cardiovascular disease. We sought to examine the effects of resveratrol in a porcine model of metabolic syndrome and chronic myocardial ischemia. Yorkshire swine were fed either a normal diet (control), a high cholesterol diet (HCD), or a high chole...

journal_title：European journal of pharmacology

authors： Robich MP,Osipov RM,Chu LM,Han Y,Feng J,Nezafat R,Clements RT,Manning WJ,Sellke FW

更新日期：2011-08-16 00:00:00

abstract：:The effects of ZD0947, a novel ATP-sensitive K+ channel (KATP channel) opener, on the activity of reconstituted KATP channels were investigated using cell-attached recordings. KATP channels were studied in HEK 293 cells by co-expression of inwardly rectifying-6 family K+ channel subunits (Kir6.x: Kir6.1 and Kir6.2) wi...

journal_title：European journal of pharmacology

authors： Mori K,Yamashita Y,Teramoto N

更新日期：2016-11-15 00:00:00

abstract：:We have tested for anti-nociceptive effects of the anticonvulsant KCNQ channel opener, N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethyl ester (retigabine), in rat models of experimental pain. In the chronic constriction injury and spared nerve models of neuropathic pain, injection of retigabine (5 and 20 ...

journal_title：European journal of pharmacology

authors： Blackburn-Munro G,Jensen BS

更新日期：2003-01-24 00:00:00

abstract：:The pharmacological properties of two angiotensin II analogues containing carboranylalanine (Car) are reported. Sar-Arg-Val-Tyr-Val-His-Pro-Car is a weak partial agonist showing 15% intrinsic activity and a very long lasting action, specific for the angiotensin II receptor of the rabbit aorta. Sar-Arg-Val-Car-Val-His-...

journal_title：European journal of pharmacology

authors： Escher E,Guillemette G,Leukart O,Regoli D

更新日期：1980-09-05 00:00:00

abstract：:Mechanical responses of the mouse colon to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were measured in vitro. MPTP caused muscle relaxation with an onset time of about 10 s. This relaxation was inhibited by propranolol. Pretreatment of the animals with reserpine significantly reduced the MPTP-induced relaxati...

journal_title：European journal of pharmacology

authors： Hanani M

更新日期：1990-01-17 00:00:00

abstract：:Antiepileptic and antidepressant drugs are the primary treatments for pain relief in diabetic neuropathy. Combination therapy is a valid approach in pain treatment, where a reduction of doses could reduce side effects and still achieve optimal analgesia. We examined the effects of two-drug combinations of gabapentin, ...

journal_title：European journal of pharmacology

authors： Tomić MA,Vucković SM,Stepanović-Petrović RM,Micov AM,Ugresić ND,Prostran MS,Bosković B

更新日期：2010-02-25 00:00:00

abstract：:Non-peptide antagonists of the NK1 and NK2 receptors were tested as inhibitors of the reaction time in the rat tail-flick and on the decrease of reaction time induced by the intrathecal injection of the NK1 receptor selective agonist [Sar9,Met(O2)11]SP or of the NK2 selective agonist NKA-(4-10). The decrease in reacti...

journal_title：European journal of pharmacology

authors： Picard P,Boucher S,Regoli D,Gitter BD,Howbert JJ,Couture R

更新日期：1993-03-02 00:00:00

abstract：:The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatmen...

journal_title：European journal of pharmacology

authors： Zerrouk A,Auguet M,Dabiré H,Brisac AM,Safar M,Chabrier PE

更新日期：1999-06-11 00:00:00

abstract：:The effects of intracerebroventricular (i.c.v.) or intravenous (i.v.) administration of morphine on colonic motility were investigated in conscious dogs chronically fitted with a strain gauge transducer sutured to the serosa of the proximal colon. Morphine administered i.v. (100 micrograms/kg) or i.c.v. (10 micrograms...

journal_title：European journal of pharmacology

authors： Fioramonti J,Fargeas MJ,Bueno L

更新日期：1985-10-29 00:00:00

abstract：:We used two experimental models to prove that resveratrol (trans-3,4',5-trihydroxystilbene) reduces cardiac ischemic-reperfusion injury by means of a nitric oxide- and adenosine-dependent mechanism. (1). ACUTE EX VIVO: resveratrol (10 microM, 10 min) infusion in Langendorff-perfused normoxic rat hearts significantly i...

journal_title：European journal of pharmacology

authors： Bradamante S,Barenghi L,Piccinini F,Bertelli AA,De Jonge R,Beemster P,De Jong JW

更新日期：2003-03-28 00:00:00

abstract：:P815, a murine mastocytoma cell line, possesses beta-adrenergic binding sites as assessed by using [3H]dihydroalprenolol (antagonist) and [3H]hydroxybenzylisoproterenol (agonist). The number of binding sites per cell was 29 000 for the agonist and 75 000 for the antagonist, as determined by direct binding assays and i...

journal_title：European journal of pharmacology

authors： Durieu-Trautmann O,Delavier-Klutchko C,Hoebeke J,Strosberg AD

更新日期：1985-01-22 00:00:00

abstract：:Intracellular accumulation of Mn2+ augmented the contractions induced by norepinephrine and acetylcholine in the guinea pig isolated vas deferens. Contractions repeatedly induced by norepinephrine, acetylcholine, or a high concentration of K+ decreased depending on the incubation time in Ca(2+)-free medium. The rate o...

journal_title：European journal of pharmacology

authors： Tsunobuchi-Ushijima H,Gomi Y

更新日期：1996-01-11 00:00:00

abstract：:As there is increasing evidence that purines are involved in cerebral vasodilatation, purine receptors were characterized pharmacologically in pial arteries from rabbit, cat and man, and compared with purine receptors in various non-cerebral vascular beds. Use of agonists and antagonists allows purine receptors to be ...

journal_title：European journal of pharmacology

authors： Hardebo JE,Kåhrström J,Owman C

更新日期：1987-12-15 00:00:00

abstract：:Recently we have demonstrated that 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) constricts rat aortic rings and that this effect is cyclooxygenase- and endothelium-dependent. Incubation of 20-HETE with ram seminal vesicles, a rich source of cyclooxygenase, led to the identification of vasoconstrictor metabolit...

journal_title：European journal of pharmacology

authors： Escalante B,Omata K,Sessa W,Lee SG,Falck JR,Schwartzman ML

更新日期：1993-04-22 00:00:00

abstract：:It has been suggested that morphine-6-glucuronide, a major metabolite of the opioid analgesic morphine, is more potent as an analgesic than the parent drug. This finding appears not to be due to differences in affinity for opioid receptors. Therefore, in the present study the opioid receptor mediated effects of morphi...

journal_title：European journal of pharmacology

authors： Schmidt N,Brune K,Geisslinger G

更新日期：1994-04-01 00:00:00

abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was incidentally administered to pregnant marmosets during the whole gestational period, except for the last 15 days before term. The infant monkeys were killed 5 months after birth, and dopamine and its metabolites were measured in the striatum and the nucleus accum...

journal_title：European journal of pharmacology

authors： Pérez-Otaño I,Oset C,Trinidad Herrero M,Luquin MR,Kupsch A,Oertel W,Obeso JA,Del Río J

更新日期：1992-07-07 00:00:00

abstract：:Nerve growth factor (NGF) is known to regulate the development and survival of select populations of neurons via its binding/activation of the TrkA and p75(NTR) receptors. However, in some physiological circumstances NGF dysregulation can result in debilitating pathologies, including diabetic neuropathies, interstitia...

journal_title：European journal of pharmacology

authors： Eibl JK,Strasser BC,Ross GM

更新日期：2013-05-15 00:00:00

abstract：:Meperidine has atypical opioid receptor agonist effects and shares some structural features with the phenyltropane (WIN) analogs of cocaine. In combination with 0.1 mg/kg naltrexone, meperidine produced cocaine-like discriminative stimulus effects in monkeys, whereas morphine was inactive. Both cocaine and meperidine ...

journal_title：European journal of pharmacology

authors： Izenwasser S,Newman AH,Cox BM,Katz JL

更新日期：1996-02-15 00:00:00

abstract：:The vascular effects of bradykinin were studied in rat perfused mesenteric vascular beds with active tone. Bolus injections of bradykinin (1-1000 pmol) but not des-Arg(9)-bradykinin (bradykinin B(1) receptor agonist) induced triphasic vascular responses: the initial sharp vasodilation followed by transient vasoconstri...

journal_title：European journal of pharmacology

authors： Nawa H,Kawasaki H,Nakatsuma A,Isobe S,Kurosaki Y

更新日期：2001-12-14 00:00:00

abstract：:Pretreatment with the catecholamine precursor L-DOPA but not the narcotic antagonist naloxone suppressed the tremorigenic effect of oxotremorine in mice. However, when animals were pretreated with both L-DOPA and several different doses of naloxone, there was a dose-related potentiation of the antitremor effect of L-D...

journal_title：European journal of pharmacology

authors： Quock RM,Lucas TS

更新日期：1983-11-25 00:00:00

abstract：:Histamine levels are elevated in inflammatory bowel disease. We investigated the mechanism by which histamine affects electrolyte transport in the mouse cecum. Using the Ussing-chamber voltage clamp technique, histamine was found to cause a transient concentration-dependent increase in short-circuit current, a measure...

journal_title：European journal of pharmacology

authors： Homaidan FR,Tripodi J,Zhao L,Burakoff R

更新日期：1997-07-23 00:00:00