DSP-4 lesioning prevents the enhancement of dopamine and 5-hydroxytryptamine mediated behavioural changes by repeated electroconvulsive shock.

abstract：:Many studies have demonstrated that cyclophosphamide (CPA) can affect hepatic cytochrome p450 (CYP) isoenzyme activity in animals. We have investigated the effect of CPA on gene expression of various CYP enzymes as well as beta-actin in the human acute promyelocytic leukemia cell line (HL-60S) and its multidrug-resist...

journal_title：European journal of pharmacology

authors： Xie HJ,Lundgren S,Broberg U,Finnström N,Rane A,Hassan M

更新日期：2002-08-09 00:00:00

abstract：:The effect of three selective bradykinin B(2) receptor antagonists, MEN11270 (H-DArg-Arg-Pro-Hyp-Gly-Thi-c(Dab-DTic-Oic-Arg)c(7gamma-1 0alpha)), Icatibant (H-DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg-OH), and FR173567 ((E)-3-(6-acetamido-3-pyridyl)-N-[N-[2, 4-dichloro-3-[(2-methyl-8-quinolinyl) oxymethyl] phenyl]-N-me...

journal_title：European journal of pharmacology

authors： Meini S,Patacchini R,Giuliani S,Lazzeri M,Turini D,Maggi CA,Lecci A

更新日期：2000-01-28 00:00:00

abstract：:The nerve growth factor (NGF) is a neurotrophic factor essential for the development and survival of neurons. It has also been identified as a mediator of inflammation and can cause airway hyperresponsiveness [Frossard et al., Eur. J. Pharmacol. 500, 453 (2004)]. Evidence in rodents suggests a link between tachykinins...

journal_title：European journal of pharmacology

authors： Naline E,Höglund CO,Vincent F,Emonds-Alt X,Lagente V,Advenier C,Frossard N

更新日期：2007-04-10 00:00:00

abstract：:Non-peptide antagonists of the NK1 and NK2 receptors were tested as inhibitors of the reaction time in the rat tail-flick and on the decrease of reaction time induced by the intrathecal injection of the NK1 receptor selective agonist [Sar9,Met(O2)11]SP or of the NK2 selective agonist NKA-(4-10). The decrease in reacti...

journal_title：European journal of pharmacology

authors： Picard P,Boucher S,Regoli D,Gitter BD,Howbert JJ,Couture R

更新日期：1993-03-02 00:00:00

abstract：:The interaction of phencyclidine, dexoxadrol, their analogs and stereoisomers with phencyclidine receptors was compared to their ability to induce stereotyped behavior and ataxia after i.c.v. administration to rats. The order of potency for binding to phencyclidine receptors revealed that among the stereoisomers of ph...

journal_title：European journal of pharmacology

authors： Contreras PC,Rice KC,Jacobson AE,O'Donohue TL

更新日期：1986-02-11 00:00:00

abstract：:The efficacy of SR 47436 (BMS-186295), 2-n-butyl-3-[(2'-(1H-tetrazol-5-yl)- biphenyl-4-yl)methyl]-1,3-diaza-spiro[4,4]non-1-en-4-one, a non-peptide angiotensin AT1 receptor antagonist, was characterized in various conscious hypertensive rat models. In spontaneously hypertensive rats, single intravenous or oral doses o...

journal_title：European journal of pharmacology

authors： Lacour C,Canals F,Galindo G,Cazaubon C,Segondy D,Nisato D

更新日期：1994-11-03 00:00:00

abstract：:A high dose of apomorphine, a stimulator of brain dopamine receptors, caused a reduction in total sleep, intermediate sleep and a delayed appearance of paradoxical sleep. With a lower dose, a small and not significant trend toward an increase of paradoxical sleep was observed. Spiroperidol, considered as a specific bl...

journal_title：European journal of pharmacology

authors： Kafi S,Gaillard JM

更新日期：1976-08-01 00:00:00

abstract：:The anticancer drugs camptothecin (CPT) and topotecan (TPT) are known DNA topoisomerase I inhibitors which cause DNA damage and lead to cell death. In this study we provide evidence that CPT and TPT also interfere with the elements of cytoskeleton - microtubules and actin filaments which could be partly responsible fo...

journal_title：European journal of pharmacology

authors： Wang X,Tanaka M,Krstin S,Peixoto HS,Moura CCM,Wink M

更新日期：2016-10-15 00:00:00

abstract：:Platinum resistance is a major limitation in the treatment of ovarian cancer. Combination of natural compounds with platinum-based agents is a new strategy for cancer chemotherapy. Recently, we found that scutellarin sensitized the anticancer effect of cisplatin to ovarian cancer cells. How scutellarin interacts with ...

journal_title：European journal of pharmacology

authors： Xie Z,Guo Z,Lei J,Yu J

更新日期：2019-02-05 00:00:00

abstract：:Eating disorders constitute major medical health problems in the western world. Even though little is known about the mechanisms behind abnormal eating behavior, it has become clear that the central nervous system (CNS), particularly the hypothalamus, plays a significant role. The anorexic anx/anx mouse is a unique mo...

journal_title：European journal of pharmacology

authors： Johansen JE,Fetissov S,Fischer H,Arvidsson S,Hökfelt T,Schalling M

更新日期：2003-11-07 00:00:00

abstract：:Dantrolene sodium (DaNa) markedly depressed the frequency of spontaneous miniature potentials at the frog neuromuscular junction. Its action is still observed at low [Ca2+]o and is little affected by temperature; its effect is not readily reversible. Theophylline antagonises the action of DaNa. DaNa prevents the stimu...

journal_title：European journal of pharmacology

authors： Statham HE,Duncan CJ

更新日期：1976-09-01 00:00:00

abstract：:The effect of KC 2450 (racemic 3,5-cis-3-methylamino-2,3,4,5-tetrahydro-1-benzoxepine-5-ol hydrochloride) on lower esophageal sphincter pressure in pentobarbital-anesthetized dogs was determined and compared to the effect of metoclopramide. The ED20 value (i.e. the dose that increased lower esophageal sphincter pressu...

journal_title：European journal of pharmacology

authors： Fowler PJ,Nelson AH,Price WJ,Sarau HM,Grous M,Lombardi DM,Barone FC,Ormsbee HS 3rd

更新日期：1987-10-13 00:00:00

abstract：:MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was incidentally administered to pregnant marmosets during the whole gestational period, except for the last 15 days before term. The infant monkeys were killed 5 months after birth, and dopamine and its metabolites were measured in the striatum and the nucleus accum...

journal_title：European journal of pharmacology

authors： Pérez-Otaño I,Oset C,Trinidad Herrero M,Luquin MR,Kupsch A,Oertel W,Obeso JA,Del Río J

更新日期：1992-07-07 00:00:00

abstract：:Hruska et al. (1980) reported that hypophysectomy prevented the onset of dopamine receptor supersensitivity. We have repeated this investigation administering haloperidol (0.75 mg/day) or sulpiride (2 X 15 mg/day) or saline for 17 days, followed by a 3 day drug washout period, to sham-operated or hypophysectomised rat...

journal_title：European journal of pharmacology

authors： Jenner P,Rupniak NM,Hall MD,Dyer R,Leigh N,Marsden CD

更新日期：1981-11-19 00:00:00

abstract：:18-Methoxycoronaridine, a novel iboga alkaloid congener, reduces drug self-administration in animal models of addiction. Previously, we proposed that these effects are mediated by the ability of 18-methoxycoronaridine to inhibit nicotinic alpha3beta4 acetylcholine receptors. In an attempt to identify more potent 18-me...

journal_title：European journal of pharmacology

authors： Pace CJ,Glick SD,Maisonneuve IM,He LW,Jokiel PA,Kuehne ME,Fleck MW

更新日期：2004-05-25 00:00:00

abstract：:Haloperidol increased 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations in the striatum, nucleus accumbens and olfactory tubercle of both drug-naive rats and rats pretreated with haloperidol (10 injections). The increases in metabolite concentrations were greater in all brain regions of the naive rat...

journal_title：European journal of pharmacology

authors： Finlay JM,Jakubovic A,Fu DS,Fibiger HC

更新日期：1987-05-07 00:00:00

abstract：:We evaluated roles of kinins in allergen-induced nasal blockage and sneezing, and development of nasal hyperresponsiveness to leukotriene D4 in a Japanese cedar pollen-induced allergic rhinitis model of guinea pigs. Sensitised guinea pigs were repeatedly challenged by pollen inhalation once every week. Neither a brady...

journal_title：European journal of pharmacology

authors： Sugahara S,Nabe T,Mizutani N,Takenaka H,Kohno S

更新日期：2003-08-29 00:00:00

abstract：:Multiple methamphetamine administrations rapidly decrease rat striatal dopamine transporter activity. To determine the species specificity of this phenomenon, the present studies examined effects of this stimulant on the dopamine transporter in mice. As in rats, multiple methamphetamine injections rapidly reduced stri...

journal_title：European journal of pharmacology

authors： Sandoval V,Hanson GR,Fleckenstein AE

更新日期：2000-12-15 00:00:00

abstract：:A close relationship between the renin-angiotensin system and the pathophysiology of diabetic retinopathy has been suggested, several angiotensin II type 1 receptor (angiotensin AT1 receptor) antagonists being effective in animal models. Therefore, we examined the efficacy of an angiotensin AT1 receptor antagonist, ol...

journal_title：European journal of pharmacology

authors： Nakamura H,Inoue T,Arakawa N,Shimizu Y,Yoshigae Y,Fujimori I,Shimakawa E,Toyoshi T,Yokoyama T

更新日期：2005-04-11 00:00:00

abstract：:Intravenous amiodarone (Amiodarone i.v.) is widely used to treat cardiac arrhythmias. The most frequent clinical adverse event associated with Amiodarone i.v. administration is systemic hypotension which has been attributed to the cosolvents used in the formulation, polysorbate 80 and benzyl alcohol. To minimize hypot...

journal_title：European journal of pharmacology

authors： Cushing DJ,Kowey PR,Cooper WD,Massey BW,Gralinski MR,Lipicky RJ

更新日期：2009-04-01 00:00:00

abstract：:On exposure to triphosphatic nucleotides vas deferens DDT1 MF-2 smooth muscle cells responded with an outward K+ current as measured with the whole-cell patch clamp configuration. The rank order of potency was: ATP greater than UTP greater than TTP greater than CTP = GTP. The responses evoked by these agonists were bl...

journal_title：European journal of pharmacology

authors： Van der Zee L,Nelemans A,Den Hertog A

更新日期：1992-05-14 00:00:00

abstract：:Changrolin (2, 6-bis[pyrrolidin-1-ylmethyl]-4-[quinazolin-4-ylamino] phenol) is an anti-arrhythmic drug derived from β-dichroine, an active component of the Chinese medicinal herb, Dichroa febrifuga Lour. To elucidate the mechanism underlying the anti-arrhythmic effect of changrolin, we used the whole-cell patch-clamp...

journal_title：European journal of pharmacology

authors： Chen WH,Yang D,Wang WY,Zhang J,Wang YP

更新日期：2010-11-25 00:00:00

abstract：:Macrophages play important roles in the healing and remodeling of cardiac tissues after myocardial ischemia/reperfusion (MI/R) injury. Here we investigated the potential effects of salvianolic acid B (SalB), one of the abundant and bioactive compounds extracted from Chinese herb Salvia Miltiorrhiza (Danshen), on macro...

journal_title：European journal of pharmacology

authors： Zhao M,Li F,Jian Y,Wang X,Yang H,Wang J,Su J,Lu X,Xi M,Wen A,Li J

更新日期：2020-03-15 00:00:00

abstract：:The bronchial smooth muscle of the rat was examined for contractile responses to excitatory amino acids. The nerve-mediated contraction induced by electrical field stimulation was enhanced by exogenous L-glutamate (L-Glu). The apparent affinity (ED50) of L-Glu was 3.5 +/- 0.1 mM. Both tetrodotoxin and hemicholinium-3 ...

journal_title：European journal of pharmacology

authors： Aas P,Tansø R,Fonnum F

更新日期：1989-05-02 00:00:00

abstract：:The identity of the muscarinic receptor subtype in the chick ileum was investigated in functional and binding studies. Preliminary studies [Choo, L.-K., Mitchelson, F., Napier, P. 1988. J. Auton. Pharmacol. 8, 259-266] suggested apparent avian and mammalian family differences in the muscarinic receptor profile of ilea...

journal_title：European journal of pharmacology

authors： Darroch S,Irving HR,Mitchelson FJ

更新日期：2000-08-18 00:00:00

abstract：:Sickness behavior is a series of behavioral and psychological changes that develop in inflammatory disease, including infections and cancers. Administration of the bacterial endotoxin lipopolysaccharide (LPS) induces sickness behavior in rodents. Genipin, an aglycon derived from an iridoid glycoside geniposide extract...

journal_title：European journal of pharmacology

authors： Araki R,Hiraki Y,Yabe T

更新日期：2014-10-15 00:00:00

abstract：:Affinity cross-linking of the bradykinin B2 receptor was performed using [125I-Tyr8]bradykinin, disulfosuccinimidyl tartrate as linker and crude membranes from guinea pig ileum smooth muscle immobilized on Whatman GF/B glass fiber filters. After SDS (sodium dodecylsulfate)-polyacrylamide gel electrophoresis under redu...

journal_title：European journal of pharmacology

authors： Graness A,Liebmann C

更新日期：1994-07-15 00:00:00

abstract：:The amyloid precursor protein (APP) has been mainly studied in its role in the production of amyloid β peptides (Aβ), because Aβ deposition is a hallmark of Alzheimer's disease. Although several studies suggest APP has physiological functions, it is still controversial. We previously reported that APP increased glial ...

journal_title：European journal of pharmacology

authors： Kwak YD,Marutle A,Dantuma E,Merchant S,Bushnev S,Sugaya K

更新日期：2011-01-10 00:00:00

abstract：:Dopamine agents (saline in control groups) were coadministered with indomethacin by either single or repeated application. The ulcerogenic effect (erosions and/or ulcers) of repeated given indomethacin on gastric mucosa differed clearly from that on intestinal mucosa. The effect on intestinal mucosa was markedly great...

journal_title：European journal of pharmacology

authors： Sikirić P,Rotkvić I,Mise S,Krizanac S,Gjuris V,Jukić J,Suchanek E,Petek M,Udovicić I,Kalogjera L

更新日期：1988-12-06 00:00:00

abstract：:In clinical practice, patients with epilepsy are frequently associated with psychiatric disorders, including cognitive impairment, depression, and attention deficit hyperactivity disorder. In fact, patients with epilepsy often take centrally acting drugs, such as antidepressants and anxiolytics; however, it remains un...

journal_title：European journal of pharmacology

authors： Takechi K,Suemaru K,Kawasaki H,Araki H

更新日期：2011-12-30 00:00:00