Nucleotide receptors on DDT1 MF-2 vas deferens cells.

abstract：:An 125I-iodinated ryanodine analog, modified by attaching an iodo-Cbz-beta-alanyl group to the C10eq hydroxy of ryanodine (iodo-carbobenzyloxy-beta-alanyl-ryanodine), binds to cardiac sarcoplasmic reticulum Ca2+ release channels with equal affinity as [3H]ryanodine. In the present study, both iodo-Cbz-beta-alanyl-ryan...

journal_title：European journal of pharmacology

authors： Bowling N,Mais DE,Gerzon K,Watanabe AM

更新日期：1994-08-16 00:00:00

abstract：:The nicotinic acetylcholine receptors in the rat stomach were characterized by means of a radioligand binding assay with (-)-[3H]nicotine as ligand. Saturation binding studies on the gastric fundus membranes revealed the presence of two binding sites with dissociation constant (KD) values of 3.1 and 289 nM, and maximu...

journal_title：European journal of pharmacology

authors： Nishikawa H,Taniguchi T,Ninomiya H,Fujiwara M

更新日期：1988-01-27 00:00:00

abstract：:The alpha 1-adrenoceptors present in the liver of rhesus monkeys was characterized using [3H]prazosin. This radioligand binds to monkey liver membranes with high affinity (KD 0.33 nM) to a moderately abundant number of sites (97 fmol/mg of protein). These sites were characterized pharmacologically, by binding competit...

journal_title：European journal of pharmacology

authors： García-Sáinz JA,Romero-Avila MT,González-Espinosa C

更新日期：1996-09-12 00:00:00

abstract：:In the presence of l-serine borate, salbutamol was much more effective in reversing rather than preventing LTC4-induced contractions of guinea-pig trachea. This suggests that different mechanisms are involved in initiating versus maintaining LTC4-induced contractions. In addition, the ability of salbutamol pretreatmen...

journal_title：European journal of pharmacology

authors： Hay DW,Muccitelli RM,Wilson KA,Wasserman MA,Torphy TJ

更新日期：1986-07-31 00:00:00

abstract：:The role of the endogenous corticotropin-releasing hormone (CRH) system in the regulation of heart rate, PQ interval (a measure of vagal activity), gross activity and release of adrenocorticotropic hormone (ACTH), noradrenaline and adrenaline into the blood during conditioned fear was studied in freely moving rats. In...

journal_title：European journal of pharmacology

authors： Nijsen MJ,Croiset G,Diamant M,Stam R,Kamphuis PJ,Bruijnzeel A,de Wied D,Wiegant VM

更新日期：2000-02-11 00:00:00

abstract：:Glutamine is the most abundant amino acid in the bloodstream. It is important in nucleotide synthesis, is anti-catabolic, has anti-oxidant properties via metabolism to glutathione, may enhance immune responsiveness and possesses immunoregulatory functions. Moreover, it reduces atrophy of intestinal mucosa in animals o...

journal_title：European journal of pharmacology

authors： Mondello S,Galuppo M,Mazzon E,Italiano D,Mondello P,Aloisi C,Cuzzocrea S

更新日期：2011-05-01 00:00:00

abstract：:The ability of the kappa-opioid receptor agonist U69593 to attenuate the sensitization and cross-sensitization which develops to the conditioned rewarding effects of morphine and cocaine was examined using an unbiased place-preference conditioning procedure. The influence of U69593 treatment upon sensitization and cro...

journal_title：European journal of pharmacology

authors： Shippenberg TS,LeFevour A,Thompson AC

更新日期：1998-03-12 00:00:00

abstract：:The affinity and intrinsic activity of dopamine receptor agonists were determined at the human dopamine hD21 and hD4.4 receptors. (-)-3-Hydroxy-N-n-propylpiperidine ((-)3-PPP) had an intrinsic activity of 46% and 83%, whereas (+)-N-propylnorapomorphine ((+)-NPA) had intrinsic activities of 61% and 58% at the dopamine ...

journal_title：European journal of pharmacology

authors： Lahti RA,Mutin A,Cochrane EV,Tepper PG,Dijkstra D,Wikström H,Tamminga CA

更新日期：1996-04-22 00:00:00

abstract：:Depression is a serious mental disorder that is becoming more common. To better treat patients suffering from this illness, elucidation of the underlying psychopathological and neurobiological mechanisms of depression is needed. Based on the evidence, we sought to investigate the effects of hesperidin in a model of de...

journal_title：European journal of pharmacology

authors： Antunes MS,Jesse CR,Ruff JR,de Oliveira Espinosa D,Gomes NS,Altvater EET,Donato F,Giacomeli R,Boeira SP

更新日期：2016-10-15 00:00:00

abstract：:Inhibition of local cortisol regeneration from circulating cortisone by blocking 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been shown to ameliorate the risk factors associated with the metabolic syndrome. Chronic modulation of glucocorticoid homeostasis may result in hypothalamic-pituitary-adrenal (HPA) axis s...

journal_title：European journal of pharmacology

authors： Hamilton BS,Schoelch C,Schuler-Metz A,Krosky P,Lala DS,Claremon DA,McGeehan GM

更新日期：2016-10-15 00:00:00

abstract：:The effect of monocrotaline-induced pulmonary hypertension on alpha(1)-adrenoceptor-mediated contractions of pulmonary artery segments was studied. In control and monocrotaline-treated rats, noradrenaline evoked concentration-dependent contractions of the pulmonary artery. There was no change in the potency and affini...

journal_title：European journal of pharmacology

authors： Oriowo MA,Chandrasekhar B,Kadavil EA

更新日期：2003-12-15 00:00:00

abstract：:Alzheimer's disease is associated with glial activation and increased levels of the cytokines as well as impaired forebrain cholinergic function. Current therapies focus on enhancing cholinergic function by administrating acetylcholinesterase inhibitors, such as galantamine. Epidemiological results also suggest that a...

journal_title：European journal of pharmacology

authors： Wenk GL,Rosi S,McGann K,Hauss-Wegrzyniak B

更新日期：2002-10-25 00:00:00

abstract：:The ability of the conotoxin rho-TIA, a 19-amino acid peptide isolated from the marine snail Conus tulipa, to antagonize contractions induced by noradrenaline through activation of alpha1A-adrenoceptors in rat vas deferens, alpha1B-adrenoceptors in rat spleen and alpha1D-adrenoceptors in rat aorta, and to inhibit the ...

journal_title：European journal of pharmacology

authors： Lima V,Mueller A,Kamikihara SY,Raymundi V,Alewood D,Lewis RJ,Chen Z,Minneman KP,Pupo AS

更新日期：2005-01-31 00:00:00

abstract：:We examined the effects of YM-31636 (2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole monofumarate), a novel 5-HT3 receptor agonist, on gastrointestinal functions including visceral pain reflex in rats. Injection of YM-31636 increased the number of fecal pellets. This effect was completely inhibited by ramosetron, ...

journal_title：European journal of pharmacology

authors： Kiso T,Ito H,Miyata K,Kamato T,Naitoh Y,Iwaoka K,Yamaguchi T

更新日期：2001-11-09 00:00:00

abstract：:Berberine, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous medicinal plants and has an array of pharmacological properties. It has been used in Ayurvedic and Chinese medicine for its antimicrobial, antiprotozoal, antidiarrheal and antitrachoma activity. Moreover, several clinical and preclin...

journal_title：European journal of pharmacology

authors： Kumar A,Ekavali,Chopra K,Mukherjee M,Pottabathini R,Dhull DK

更新日期：2015-08-15 00:00:00

abstract：:Morphine-induced analgesia, and the development of morphine-induced tolerance and dependence was determined in mice which had drunk caffeinated water (1 mg/ml) for 14 days or in mice which had received (-)-N6-(phenylisopropyl)-adenosine (PIA) 1 mg/kg i.p. for 14 days. Analgesia was assessed by the tail flick assay. Th...

journal_title：European journal of pharmacology

authors： Ahlijanian MK,Takemori AE

更新日期：1986-01-14 00:00:00

abstract：:The adenosine-receptor modulation of noradrenaline release was compared in prostatic and epididymal portions of rat vas deferens. In both portions, tritium overflow elicited by electrical stimulation (100 pulses/8 Hz) was reduced by the adenosine A(1) receptor agonist, N(6)-cyclopentyladenosine, and enhanced by the no...

journal_title：European journal of pharmacology

authors： Queiroz G,Diniz C,Gonçalves J

更新日期：2002-07-12 00:00:00

abstract：:Translational research for neurodegenerative disease depends intimately upon animal models. Unfortunately, promising therapies developed using mouse models mostly fail in clinical trials, highlighting uncertainty about how well mouse models mimic human neurodegenerative disease at the molecular level. We compared the ...

journal_title：European journal of pharmacology

authors： Burns TC,Li MD,Mehta S,Awad AJ,Morgan AA

更新日期：2015-07-15 00:00:00

abstract：:The effect of xanthone on smooth muscle was studied in thoracic aorta isolated from rats. Xanthone relaxed the norepinephrine-induced contraction of rat thoracic aorta. This relaxing effect of xanthone persisted in endothelium-denuded aorta suggesting that the relaxation induced by xanthone is endothelium-independent....

journal_title：European journal of pharmacology

authors： Cheng YW,Kang JJ

更新日期：1997-10-01 00:00:00

abstract：:Clearance of apoptotic cells, so-called efferocytosis, by alveolar macrophages (AMs) is important for lung homeostasis and is impaired in pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease and asthma. Carbocisteine, a mucoregulatory drug, corrects the contents of fucose in airway mucus and ...

journal_title：European journal of pharmacology

authors： Inoue M,Ishibashi Y,Nogawa H,Yasue T

更新日期：2012-02-29 00:00:00

abstract：:We synthesized the o-, m- and p-bromo derivatives of dl-threo-methylphenidate from the corresponding bromophenylacetonitriles by modification of the literature synthesis of methylphenidate (Panizzon, Helv. Chim. Acta 1944, 27, 1748). In in vitro binding assays all three dl-threo bromo compounds had higher affinities t...

journal_title：European journal of pharmacology

authors： Pan D,Gatley SJ,Dewey SL,Chen R,Alexoff DA,Ding YS,Fowler JS

更新日期：1994-10-24 00:00:00

abstract：:The protective effect of coenzyme Q10 against testicular toxicity induced by sodium arsenite (10mg/kg/day, orally for two consecutive days) was investigated in rats. Coenzyme Q10 treatment (10mg/kg/day, i.p.) was applied for five consecutive days, starting three days before arsenite administration. Coenzyme Q10 signif...

journal_title：European journal of pharmacology

authors： Fouad AA,Al-Sultan AI,Yacoubi MT

更新日期：2011-03-25 00:00:00

abstract：:The present study has examined the functional activity of the 5-HT1D receptor agonist, sumatriptan, and antagonists, GR127935 (2'-methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxyl ic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide), GR55562 (3-[3-(dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridiny...

journal_title：European journal of pharmacology

authors： Walsh DM,Beattie DT,Connor HE

更新日期：1995-12-04 00:00:00

abstract：:The novel substituted benzamide eticlopride, (S)-(-)-5-chloro-3-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxy salicylamide hydrochloride (A38503; FLB 131), was radiolabelled to high specific activity and used for in vivo receptor binding studies in the rat brain. Intravenous injections of [3H]eticlopride resulted...

journal_title：European journal of pharmacology

authors： Köhler C,Hall H,Gawell L

更新日期：1986-01-21 00:00:00

abstract：:Sulfonylurea drugs exert their insulinotropic action by inhibiting ATP-sensitive potassium channels in the pancreas. However, these channels are also expressed in myocardial and vascular smooth muscle, implicating possible detrimental cardiovascular effects. Aim of the present study was to investigate the inhibitory p...

journal_title：European journal of pharmacology

authors： Engbersen R,Masereeuw R,van Gestel MA,Siero HL,Moons MM,Smits P,Russel FG

更新日期：2012-04-15 00:00:00

abstract：:Mouse gastric fundus strips were relaxed by ultraviolet light (UV) irradiation, exogenous nitric oxide (NO), isoproterenol, S-nitrosoglutathione, S-nitroso-L-cysteine and S-nitroso-N-acetyl-penicillamine. Glutathione did not affect relaxations in response to UV irradiation, exogenous NO and isoproterenol while inhibit...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2002-08-30 00:00:00

abstract：:Present study was undertaken to evaluate the protective effect of 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose (PGG) against transient global ischemia/reperfusion (I/R)-induced brain injury in rats. Sixty minutes of global ischemia, followed by 24h of reperfusion caused significant alterations in cognition and memory (...

journal_title：European journal of pharmacology

authors： Viswanatha GL,Shylaja H,Mohan CG

更新日期：2013-11-15 00:00:00

abstract：:27-O-Caffeoyl myricerone (50-235) is a nonpeptide endothelin receptor antagonist which is highly selective for the endothelin ETA receptor subtype. In order to determine which functional groups in 50-235 are essential for its activity, we examined the potencies of 50-235 and its derivatives to inhibit [125I]endothelin...

journal_title：European journal of pharmacology

authors： Mihara S,Sakurai K,Nakamura M,Konoike T,Fujimoto M

更新日期：1993-10-15 00:00:00

abstract：:The effects of (-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'- trifluoromethylpropiophenone monohydrochloride (NK433), a novel centrally acting muscle relaxant, on masticatory muscle reflexes were investigated in rats. NK433 inhibited the monosynaptic tonic vibration reflex of the masseter muscle and the polysynaptic tonic pe...

journal_title：European journal of pharmacology

authors： Ozawa Y,Komai C,Sakitama K,Ishikawa M

更新日期：1996-02-29 00:00:00

abstract：:The pruritogenic potency of tryptase and its involvement in anti-pruritic effect of intravenous nafamostat mesilate (NFM) were studied in mice. An intradermal injection of tryptase (0.05-1 ng/site) elicited scratching in ICR mice, while chymase was without effects at doses of 0.05-50 ng/site. The dose-response curve o...

journal_title：European journal of pharmacology

authors： Ui H,Andoh T,Lee JB,Nojima H,Kuraishi Y

更新日期：2006-01-13 00:00:00